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Biomedical subjects

M Neuman

Publications and source records attributed to M Neuman.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

The defibrillating effect of catecholamine reuptake inhibitors.

In previous studies we hypothesized that spontaneous termination of ventricular fibrillation (TVF) requires a high cardiac catecholamine level ([CA]) during VF. During VF, sympathetic activity is enhanced but in the majority of cases [CA] does not reach the level required for self-defibrillation, most likely due to their relatively high reuptake by sympathetic nerve terminals. One possibility of obtaining TVF is by elevation of the [CA] during VF, either by catecholamine intracoronary injection or by treatment with compounds that inhibit catecholamine reuptake. To examine this assumption, we studied the effect of VF on 3 closely related compounds: talopram, talsupram and citalopram, with norepinephrine uptake inhibition (IC50NE) of 2.9, 0.79 and 8800 and dopamine (DA) uptake inhibition (IC50DA) of 44000, 9300 and 41000, respectively, as well as 2 enantiomers of a cis-1-piperazino-3-phenylindan derivative (Lu20-037 and Lu20-036) with IC50NE of 2.5 and 910 and IC50DA of 2.3 and 1700, respectively. The results support our hypothesis relating the defibrillating effect of a compound to its IC50NE, while its inhibitory effect on DA uptake seems to conteract the NE effect.

Animals↗
PubMedDate not supplied

Percutaneous nephrolithotomy.

Our initial experience with percutaneous nephrolithotomy in 46 randomly selected patients included 16 who had undergone previous surgery for calculi. A urologist and radiologist cooperated closely in carrying out the procedure, which was performed in one or two stages (16 and 30 cases respectively). Calculi were successfully removed from 80.4% of the patients with the use of grasping forceps or ultrasonic lithotripsy. Operating time ranged from 30 to 180 min and the average hospital stay was 8 days. Complications were few and of a transient nature. Further experience and patient selection is necessary in order to reduce the time and cost of this procedure.

Adolescent↗