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M Negoro

Publications and source records attributed to M Negoro.

53 records · Page 3Linked to original sources
PubMed1985

Diagnosis, treatment and postoperative results of Cushing's disease.

One hundred patients with Cushing's disease were operated on in Nagoya University Hospital between January 1977 and January 1984. Pituitary adenomas were found and resected in 93 cases and complete clinical remissions were observed in 89 treated by operation alone and in two additional cases by operation followed with radiotherapy. The clinical features, pre-operative endocrine data, radiological findings including high resolution CT with coronal and sagittal reconstructions, data of selective venous sampling, operative findings, tumour pathology, postoperative clinical course, postoperative endocrine results and follow-up findings are presented and discussed.

Adenoma, Basophil↗
PubMed1985

[ACTH dependent Cushing's syndrome with an empty sella turcica: report of three cases with emphasis on diagnostic value of selective venous sampling].

Three cases of ACTH dependent Cushing's syndrome are reported with emphasis on diagnostic value of selective venous sampling. Case 1. A 44-year-old female was admitted to our hospital with clinical diagnosis of Cushing's disease. Endocrinological examination revealed typical data of Cushing's disease. High resolution CT scan showed an empty sella turcica, and a chest film showed multi-cystic lesion in the left lower lung field. In the first trial of selective venous sampling, central to peripheral ACTH ratio (C/P ratio) was high at the superior vena cava. So, an ectopic ACTH producing lung tumor was strongly suspected. Further examinations for lung tumor were performed, and finally showed lung cryptococcosis. Therefore, selective venous sampling was performed again, and pituitary ACTH dependency was diagnosed. An eccentric pituitary microadenoma was successfully removed by transsphenoidal surgery. Case 2. A 54-year-old female was admitted to our hospital with clinical diagnosis of Cushing's disease. In the endocrinological examinations plasma ACTH was not respond to provocation of LVP or CRF. In selective venous sampling, C/P ratios of ACTH were not greater than 2.0 at any sampling site. Further examinations showed lung tumor in the lower lobe of left lung. This tumor was surgically proved to be an ectopic ACTH producing lung carcinoid. Case 3. A 24-year-old female was admitted to our hospital for the purpose of further examination of Cushing's disease. Three years previously exploratory transsphenoidal surgery demonstrated an empty sella without adenoma. She received postoperative radiation therapy with a dose of 5000 rad. Endocrinological examination showed typical data due to Cushing's disease.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenoma↗
PubMed1982

[The clinical application of intracranial artery canulation technique (author's transl)].

The introduction of the microscope into the neurosurgical operating theater brought the significant change on its operative results. However, even by means of the meticulous microsurgical techniques, certain intracranial lesion like deep-seated AVM cannot yet be successfully treated. Instead of the extravascular approach, intravascular treatment of these lesions has been evolved and become the great aid for the therapeutic purpose. In 1974 Serbinenko published his excellent work about his detachable balloon catheter technique. He succeeded in treating the intracranial lesions by the intravascular approach with the more exact manner than before. The balloon could make it possible to guide the small catheter into the distal branch of intracranial arteries. And also the balloon was detached and use as embolus. Until now, various balloon catheters become clinically available. Among them the catheter which Kerber devised is made of soft silicone and equipped with microballoon at the distal end. Although the balloon itself cannot be detached, it has a small hole at its top and can deliver the fluid through this opening (calibrated leak). The method for this catheter usage is as follows. Using Seldinger technique, the non-tapered thin wall catheter has to be placed on the proximal side of the attempted artery as the introducing catheter. Through it, balloon catheter is cannulated coaxically and navigated more distally with the inflation or deflation of the balloon. Clinical application of this catheter include the superselective angiography, drug infusion and selective embolization. For the embolization, fluid embolus must be chosen. At this time cyanoacrylate, a potent tissue adhesive, is used as the embolus and injected with the mixture of Pantopaque and tantalum powder. Two cases of deep seated cerebral AVM were treated by selective embolization. AVM was completely occluded in one case, in the other case the embolization was interrupted because of worsening of neurologic defecits. In conclusion, the calibrated leak balloon catheter (Kerber) has wide range of clinically applicable potential and will become the great aid for the intravascular treatment.

Adult↗
PubMed1981

Pineal Tumors: clinical diagnosis, with special emphasis on the significance of pineal calcification.

The clinical presentations, findings of neuroradiological examinations, laboratory findings, pathological diagnoses, methods of treatment, and results of follow-up of 43 cases of pineal tumor collected at the Nagoya University Hospital from 1958 to 1979 are reviewed. The definitions of calcification of the pineal body and of pineal tumor are given. There is a significant difference in the incidence of calcification of the pineal body between pineal teratomas and pineal germinomas. Although there is a 100% rate of calcification of the pineal body in cases of pineal germinoma, the rate is very low in cases of pineal teratoma; calcification appears in only a small percentage of the cases of teratoma mixed with germinoma or embryonal carcinoma, or both. In male patients with suprasellar germinoma, there is a high frequency of an associated pineal calcification. No pineal calcification is seen in cases of basal ganglia germinoma. The computed tomographic (CT) findings of pineal teratoma and germinoma are characteristic. CT scanning is superior for early diagnosis of suprasellar and basal ganglia germinomas.

Adolescent↗
PubMed1976

Cerebral vasospasm.

Explore the source record for details and available documents.

Adrenergic alpha-Antagonists↗
PubMedDate not supplied

Fluoride profiles in dental calculus from Japanese, Chinese and British residents.

Whether the fluoride concentrations and profiles differ in human dental calculus obtained from different countries was investigated. A total of 203 dental calculus deposits on 203 permanent teeth from residents (mean age, 52.1 years) of Nagoya (Japan), Shanghai (China), Leeds (Great Britain) and the Wuhan mountainous area (China, fluoridated area) were analysed. An abrasive microsampling procedure was used to examine fluoride distribution. There were five types of fluoride profiles in dental calculus in each area/country (designated types L, J, U, T, W). In supragingival calculus, type L (highest in the outermost layers) and type J (highest in the innermost layers) both had significantly higher values than type U (high in the surface and innermost layers) but were relatively identical. In subgingival calculus, type W (high in the outermost, mid and innermost layers) was characteristics. Calculus from the Wuhan mountainous area (fluoridated) had the highest fluoride concentration, followed by Leeds (non-fluoridated), and Nagoya and Shanghai (non-fluoridated) calculus had the lowest. Fluoride concentrations in supragingival calculus were higher in teeth extracted because of periodontal diseases than dental caries. It is concluded that fluoride concentrations and distribution in dental calculus differ from country to country, probably due to different fluoride environments.

Adult↗
PubMedDate not supplied

New simple method for purification of class I alcohol dehydrogenase.

AIMS: The purpose of this study was to develop a new simple method for purification of rat class I alcohol dehydrogenase (ADH, EC 1.1.1.1). METHODS AND RESULTS: Immobilized p-hydroxyacetophenone was used as a ligand for affinity chromatography for the initial purification step after ammonium sulfate precipitation of the cytosolic fraction of rat liver. Then the eluant was separated by using ion-exchange chromatography, and homogenous class I ADH, as judged by the results of SDS-PAGE and confirmed by the results of the amino-acid sequence of peptides degraded from a 39 kDa protein, was obtained with a high yield (57%). The purified ADH showed kinetic constants of 1.3 mmol/l for Km and 62.4 per min for Kcat with ethanol as a substrate. ADH was also successfully purified from yeast by a similar method using p-hydroxyacetophenone affinity chromatography. CONCLUSIONS: This simple method involving only two chromatographic procedures may be very useful for purification of ADH.

Alcohol Dehydrogenase↗
PubMedDate not supplied

Cerebrovascular occlusion by catheterization and embolization: clinical experience.

Intravascular occlusion by various catheterization techniques was used to treat 27 cases of carotid-cavernous fistula, giant intracavernous aneurysm, and cerebral or dural arteriovenous malformation. Several case reports are presented. The detachable balloon technique proved valuable in the treatment of traumatic carotid-cavernous fistula and giant aneurysm. Calibrated-leak balloon catheterization with fluid embolization was used to treat cerebral arteriovenous malformation. Selection of embolic material is discussed.

Adult↗