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Biomedical subjects

M Nayar

Publications and source records attributed to M Nayar.

At least 19 recordsLinked to original sources
PubMed1991

Association of autoimmunity and cicatricial pemphigoid: is there an immunogenetic basis?

A group of 34 patients with cicatricial pemphigoid was investigated for the presence of autoimmune disorders. Thirty-two percent of patients had autoimmune disease compared with 7% in the control population, a highly significant difference (p less than 0.002). Circulating autoantibodies were also significantly more common in patients (p less than 0.05). Twenty-four patients with cicatricial pemphigoid were typed for HLA. A statistically significant increase in the frequency of DR4 and DQw3 antigens was observed in these patients. These findings suggest a possible genetic basis for the autoimmune association and predisposition for development of cicatricial pemphigoid.

Adolescent↗
PubMed1989

Diagnostic value of carcinoembryonic antigen assay of pleural & peritoneal effusions in malignancy.

Carcinoembryonic antigen (CEA) assays were performed on effusion fluid and plasma samples of 55 patients; 38 with malignant and 17 with benign disease. Sensitivity of plasma CEA was 60.5 per cent while specificity was 76.5 per cent. Sensitivity of effusion fluid CEA was 52.63 per cent but specificity was 100 per cent. Sensitivity of the cytological examination of the fluid was 60.5 per cent and no false positive diagnosis was made. Detection rate of malignancy increased to 81.6 per cent (31 of 38) when cytology and effusion fluid CEA were used in adjunction for diagnosis, with 100 per cent specificity.

Ascitic Fluid↗