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Biomedical subjects

M Nasu

Publications and source records attributed to M Nasu.

At least 397 records · Page 22Linked to original sources
PubMed1981

In vitro activity of MK0787 (N-formimidoyl thienamycin) and other beta-lactam compounds against Bacteroides spp.

The susceptibilities of 82 strains of the Bacteroides fragilis group to eight beta-lactam compounds, lincomycin, and metronidazole were determined by using an agar dilution technique. MK0787 (N-formimidoyl thienamycin) was the most active compound, inhibiting all strains at a concentration of 1 microgram/ml. Metronidazole was the only other drug of similar activity. Of the beta-lactam compounds, cefoxitin and MK0787 showed uniform activity against all species, whereas most other compounds were relatively less active against Bacteroides distasonis and Bacteroides thetaiotaomicron than against B. fragilis and Bacteroides vulgatus. Using a well diffusion technique, we determined the relative stability of each beta-lactam compound to sonicated cultures of selected resistant strains. Whereas MK0787 was completely stable to inactivation--and with one exception, cefoxitin was also--ceftriaxone, cefotaxime, cephaloridine, and cefoperazone always showed some inactivation, often quite substantial. Moxalactam and ceftazidime were completely stable to some of the enzyme preparations.

Anti-Bacterial Agents↗
PubMed1981

Bacteriocin (marcescin) typing of clinically isolated Serratia marcescens.

A study of bacteriocin (marcescin) typing was carried out by an agar cross streaking method (without any induction reagent) with 654 strains of Serratia marcescens recently isolated from clinical materials in Nagasaki University Hospital. In a complete checker board experiment with 80 strains on bacteriocin production and sensitivity, 43 strains (54%) were productive, 74 (93%) were sensitive and 4 (5%) were negative. Immunity was confirmed in all strains. Eight out of 80 strains of Serratia marcescens were selected as indicators in order to achieve the best differentiation of strains in bacteriocin typing, and 654 strains were classified into 30 types by bacteriocin production typing and into 49 types by bacteriocin sensitivity typing; the former showed more stable results than the latter in reproducibility. Bacteriocins produced by this method were considered to be high molecular, phage tail-like group A bacteriocins reported by Prinsloo (1966). Bacteriocin production typing was more useful for classification and subdivision of strains than serotyping (0-group).

Bacteriocins↗
PubMed1981

Sialadenoma papilliferum: report of case.

A case of sialadenoma papilliferum, which occurred on the hard palate off a 61-year-old man, is reported. The tumor is considered to be a true neoplasm rather than hyperplasia of the duct cells of the salivary gland.

Adenoma↗
PubMed1981

Susceptibility of the species of genus bacteroides recently isolated from clinical specimens to 20 antimicrobial agents.

Susceptibility of 105 strains of bacteroides species (including 82 strains of B. fragilis, 8 strains of B. distasonis, 5 strains of B. thetaiotaomicron, 4 strains of B. vulgatus, 3 strains of B. ovatus and 3 other strains) isolated from patients to chemotherapeutic agents was determined by an agar dilution technique. Good to excellent inhibition rates (75--100% of strains) were found for carbenicillin, ticarcillin, piperacillin, apalcillin, minocycline, chloramphenicol, thiamphenicol, rifampicin, erythromycin, clindamycin, and lincomycin.

Anti-Bacterial Agents↗
PubMed1981

[[Clinical and experimental study on the genesis of lumbar spinal stenosis (author's transl)].

In recent years, the entity of lumbar spinal stenosis has been generally accepted. It's pathogenesis is thought to be the results of developmental stenosis of the lumbar spinal canal. In this paper, some factors that can produce this developmental stenosis were investigated. There were positive correlations between the degree of lumbar lordosis by using indices of Ferguson's angle and width of the lumbar spinal canal based on the Jones' body to canal ratio and body to pedicle ratio in 130 children when examined by radiograms. Experimentally induced bipedal rats are known to have the burden to develop the lordosis in the lumbar spine. They had narrower spinal canal than the quadripedal rats according to the radiograms and indices described above. These data strongly suggest that those with severe lordosis or bipedal rats have more burden to the posterior part of the lumbar vertebrae, followed by it's unusual growth leading to narrower spinal canal posteriorly.

Adolescent↗
PubMed1980

A case of severe scoliosis associated with cerebral palsy showing remarkable improvement following soft tissue release around the hip and axilla and transfer of m. tensor fasciae latae to the ribs.

A 21 year old Japanese male of normal intelligence with severe athetosis, scoliosis with pelvic obliquity, and a positive Galant's reflex was seen with complaint of difficulty in maintaining a sitting posture. After release of the soft tissues around the hip and axilla, followed by physiotherapy, he underwent ipsilateral transfer of the tensor fasciae latae to the rib cage. Six years after the final operation there has been remarkable improvement of his scoliosis and pelvic obliquity but also diminution of Galant's reflex. In addition his daily activities have been improved by the muscle transferred. He can sit for more than one hour.

Adult↗
PubMed1980

Pancreatic cancer with metastasis to the larynx.

A laryngeal metastasis from pleomorphic carcinoma of the pancreas is described. The patient was a 70-year-old male. The tumour was located on the right margin of the epiglottis. Bilateral neck lymph node metastases were also found. The patient underwent supraglottic laryngectomy, right radical neck dissection and left suprahyoid neck dissection. Following surgery, the patient's general condition deteriorated day by day, and one month after the surgery he died. The autopsy findings demonstrated a big mass of cancer in the pancreatic tail, multiple lymphatic metastases, carcinomatous peritonitis, and possibly a lymphatic spread of the pancreatic cancer to the larynx.

Aged↗
PubMed1979

Heterogeneous RNA of the Prague strain of Rous sarcoma virus caused by undiluted passages.

The size of genomic RNA in PR-RSV A passaged in chick embryo fibroblasts (CEF) or quail embryo fibroblasts (QEF) was determined by gel electrophoresis. The results showed that 3 undiluted passages resulted in heterogeneity of RNA. The heterogeneity of the smaller incomplete RNAs in the virus stock was decreased by diluted passage or cloning, but RNA of the b subunit size and a subunit RNA of complete genome size were relatively stable. These heterogeneous RNAs were characterized by hybridization analysis. The RNAs from 4 peaks hybridized with both cDNAtotal and cDNAsrc to appreciable extents, indicating that they were derived from viral RNA and that at least some of them contained the src sequence. This finding and the failure to isolate a td mutant from the undiluted-passaged virus stock or from some subclones that had a and b subunits of RNA indicate that the td virus was only a minor constituent of the incomplete virus population caused by undiluted passages. Some viruses with incomplete RNA in the virus stock could produce foci with the aid of td B77 or RAV-60. The emergence of rd viruses by undiluted passages was indicated.

Animals↗