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Biomedical subjects

M Narimatsu

Publications and source records attributed to M Narimatsu.

21 records · Page 2Linked to original sources

Fate of intramural hematoma of the aorta: CT evaluation.

PURPOSE: Our goal was to investigate the fate of intramural hematoma of the aorta. METHOD: In 32 patients with intramural hematoma of the aorta, we reviewed CT (n = 32) and MR (n = 22) findings. The diagnosis was established by CT, and regular follow-up studies were performed. RESULTS: All intramural hematomas decreased in size. Ulcer-like projections (ULPs) were identified at the initial study in 6 patients and during the follow-up period in 14 patients. The ULPs progressed to saccular aneurysm in 12 patients (mean 47.0 days), while fusiform aneurysm developed in 6 patients (mean 347.7 days) without ULP. In two patients, the affected aorta progressed to overt aortic dissection. CONCLUSION: Intramural hematoma itself usually decreases in size. However, the affected aorta can progress to aneurysm or overt aortic dissection. Development of saccular aneurysm from ULPs can be considered an early complication. In cases without ULP, fusiform aneurysm may develop as a late complication. All intramural hematomas need to be followed since it seems to be difficult to predict the exact fate of intramural hematoma from the initial imaging findings.

Adult↗

Extensive surgery for primary malignant lymphoma of the heart.

The surgical treatment of primary malignant lymphoma of the heart in a 43-year-old man is reported. The tumor was extensively resected together with the right atrial wall and both venae cavae, and the resulting defect was repaired with a bovine pericardial patch. The postoperative course was fairly stable for more than 7 months following surgery, under a regular chemotherapy regimen. The patient died of acute pneumonia on the 234th postoperative day. The autopsy findings confirmed the diagnosis of primary malignant lymphoma of the heart.

Adult↗

Treatment of thyroid carcinoma cells with four different suicide gene/prodrug combinations in vitro.

To develop a suitable suicide gene/prodrug therapy for the treatment of thyroid carcinomas, the relative therapeutic efficacy of four different suicide gene/prodrug combinations was compared in thyroid carcinomas in vitro. Herpes simplex virus thymidine kinase and ganciclovir (HSV-TK/GCV), Escherichia coli cytosine deaminase and 5-fluorocytosine (CD/5FC), E coli nitroreductase and CB1954 (NTR/CB1954), and human deoxycytidine kinase and cytosine arabinoside (dCK/AraC) were employed. The suicide genes were transduced into two thyroid carcinoma cell lines with retroviral vectors in which all the suicide genes were under the control of the same promoter. When the relative efficacy of four suicide gene/prodrugs was compared with therapeutic index and degree of bystander effect, we found a clear dissociation between these two parameters. Thus, HSV-TKIGCV demonstrated the widest therapeutic index, while CD/5FC and NTR/CB1954 showed the stronger bystander effect than HSV-TK/GCV. dCK/AraC had little efficacy. Advantages and limitations of each suicide gene/prodrug combinations are discussed.

Antineoplastic Agents↗