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Biomedical subjects

M Nardini

Publications and source records attributed to M Nardini.

At least 91 records · Page 5Linked to original sources
PubMed1977

Assessment of regional cerebral blood flow by continuous carotid infusion of krypton-81m.

In order to obtain functional images of brain perfusion, we exploited a new concept, which is to take advantage of the short half-life of a radioactive tracer. Under continuous intracarotid infusion of a solution of Kr-81m (T1/2 = 13 sec; produced from its parent, 4.6-hr Rb-81), this tracer will never reach equilibrium within the brain because of the rapid radioactive decay. Its distribution will therefore reflect regional arrival of the nuclide, indicating regional cerebral blood flow rather than volume. During continuous infusion of Kr-81m, perfusion images can be obtained by simply collecting counts with a gamma camera and recording on Polaroid film. The procedure is readily repeatable in order to get images in multiple veiws or to follow minute-by-minute changes of cerebral perfusion.

Aged↗
PubMed1976

Effect of amantadine on drug-induced parkisonism: relationship between plasma levels and effect.

Amantadine, administered at a dose of 200 mg/day, antagonized the extapyramidal symptomatology induced by neuroleptic drugs in fifteen psychiatric patients. Steady-state levels were reached within 4-7 days of treatment. Individual plasma levels ranged from 200-900 ng/ml. Apparent plasma half-lives varied from 10-28.5 h with an apparent VD of 200-400 litres. A significant relationship was found between the plasma levels of amantadine and the effects on the extrapyramidal symptomatology. The data suggest a direct effect of amantadine on dopaminergic receptors.

Adult↗