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M Nakazono

Publications and source records attributed to M Nakazono.

At least 91 records · Page 5Linked to original sources
PubMed1984

[Study of immunosuppressive acidic protein (IAP) in patients with renal cell cancer].

We evaluated immunosuppressive acidic protein (IAP) as a tumor marker in renal cell cancer. The study was comprised of patients with renal cell cancer (6 stage A, 3 stage C, 11 stage D, 7 recurrences). The IAP positive rate of renal cell cancer was 84%, the mean was 937.5 +/- 442.1 ug/ml. The positive rate is statistically higher than in other malignant and benign urological diseases. The IAP positive rate tended to increase with cancer stage. IAP may represent a tumor marker in renal cell cancer.

Adenocarcinoma↗
PubMed1983

One-stage total cystectomy and ileal loop diversion in patients over eighty years' old with bladder carcinoma. Pre- and postoperative functional reserve of various organs.

During the period from 1976 to 1981, 364 patients with bladder carcinoma were seen at the Keio University Hospital. Extensive preoperative investigation of pulmonary, cardiovascular, and renal function was obtained in all patients. Of the 12 patients studied, 9 underwent a one-stage total cystectomy and ileal loop diversion and the remaining 3 a two-stage procedure. Of the 9 patients, decreased FEV 1.0 per cent by spirometry was noted in 5, ECG abnormality such as bundle branch blocks in 8, and diminished creatinine clearance ranging from 28 to 68 ml/min were observed in all 9. Major postoperative complications included pyelonephritis in 2 patients, pneumonia in 1, pelvic abscess in 2, renal insufficiency in 3, and paralytic ileus in 2. There was no immediate postoperative death. In these elderly patients, functional reserve of the lung, heart, and kidney is less than optimal and is further decreased by major surgical procedures. Therefore, total cystectomy in the elderly patients is justifiable only in a selected group of patients, when functional status of the vital organ is thoroughly worked up and prophylactic and therapeutic measures are instituted promptly if indicated.

Aged↗
PubMed1983

Thyroid abnormalities in diabetes mellitus.

We studied the incidence of goiters and that of thyroid antibodies in 278 patients with diabetes mellitus, in whom six subjects with primary hypothyroidism were excluded, and measured their serum TSH concentrations. The incidence of goiters was 31.8%, and was higher in females than in males. The incidence of goiters in diabetics under the age of 40 was higher than that in subjects more than 40 years old, and the incidence of microsome antibodies and thyroglobulin antibodies were found to be 18.5% and 1.8%, respectively, in these two groups. The percentage of microsome antibodies was lower in diabetics between the ages of 40 and 60 than in diabetics under the age of 40 or over the age of 60. The incidence of goiters and microsome antibodies was not related to the treatment of diabetes mellitus. There was a significantly positive correlation between serum TSH concentration and age in diabetics with serum TSH levels less than 5 microU/ml. As a result, although the incidence of goiters in diabetics was found to decrease with age, the incidence of thyroid antibodies and serum TSH levels were found to increase. These findings suggest that it might be possible to observe atrophic autoimmune thyroiditis, sometimes resulting in subclinical hypothyroidism, in aged diabetics.

Adult↗
PubMed1983

[Angiography of primary retroperitoneal tumor--case report and proposal of a flow chart].

The development of ultrasonography and CT scanning has facilitated the diagnosis of primary retroperitoneal tumors. However, the tumor resection rate remains low. Factors such as tumor histology and stage of the disease play a role. Angiographic study of the tumor vessels is important in determining the procedures to the used in operative treatment. We present 3 primary retroperitoneal tumors and one malignant adrenal tumor discuss the importance of angiographic evaluation in the resection of recurrent tumors. A flow chart for surgically treated primary retroperitoneal tumor is proposed.

Adenocarcinoma↗
PubMed1982

Multimodal treatment of advanced adult Wilms tumor.

We report 2 cases of advanced adult Wilms tumor that were treated with surgery, radiation and chemotherapy. The first patient had relapse of a Wilms tumor in the liver 2 years after nephrectomy. Combination chemotherapy, consisting of actinomycin D and vincristine, radiation therapy and final resection of the liver metastasis were successful and the patient has been free of disease for 4 years. The second patient had undergone transcatheter embolization of the renal artery elsewhere with the tentative diagnosis of an inoperable renal cell carcinoma metastatic to both lungs. A left renal tumor, weighing 4,500 gm., and a tumor thrombus in the vena cava extending to the right atrium were removed, and histologically diagnosed as a Wilms tumor. Subsequent chemotherapy and radiotherapy resulted in complete disappearance of the lung metastases. We conclude that multimodal treatment, namely a well timed combination of surgery, chemotherapy and radiotherapy, could potentially eradicate the disease even at an advanced stage.

Adult↗
PubMed1981

Pre-operative intra-arterial chemotherapy for bladder cancer.

Thirteen patients with carcinoma of the bladder have been treated by arterial infusion of doxorubicin hydrochloride pre-operatively. Teflon catheters 0.25 mm in diameter were inserted by the Seldinger technique and the tips were placed in the aorta between the origin of the inferior mesenteric artery and the aortic bifurcation. The doses administered ranged from 80 mgs to 250 mgs with an average of 125 mgs. A response rate of 69% was seen. In 3 cases tumours disappeared; in a further 6 patients some tumour regression was apparent. One patient died from cardiac insufficiency. Although this method of treatment remains to be fully evaluated, preliminary results suggest that it may be an effective pre-operative treatment.

Aged↗
PubMed1980

Dose-dependency and reproducibility of the prolactin response to metoclopramide.

Six normal volunteers were tested to ascertain the dose-dependency and reproducibility of the prolactin response to metoclopramide. Furthermore, pretreatments with 1-dopa or cyproheptadine were performed. The same subjects also received intravenously 500 microgram TRH. The oral administration of 5 mg metoclopramide produced a significant rise in prolactin at 60 min and a maximal elevation at 90 min. The intravenous administration of 5 mg metoclopramide produced a significant increment at 15 min and a maximal prolactin level at 30 min. Peak prolactin levels following i.v. administration of the drug were greater than those after oral administration. Intravenous administration of 1 mg of metoclopramide produced a potential increment in plasma prolactin. Maximal prolactin response to 1 mg i.v. metoclopramide was similar to that found with 500 microgram i.v. TRH. Reproducibilities of prolactin response were good in all doses and modes of administration of metoclopramide. Pretreatment with 1-dopa inhibited the metoclopramide-induced prolactin response, but pretreatment with cyproheptadine did not influence the prolactin response to metoclopramide. Metoclopramide is a good and reproducible stimulator of prolactin secretion.

Adult↗
PubMed1978

A preliminary study of chemotherapeutic treatment for bladder tumors.

Our objective was to develop new methods of chemotherapeutic treatment for bladder tumors. Once or twice a week under cystoscopy 10 to 20 mg, doxorubicin hydrochloride were administered directly into the tumors. This procedure was repeated until the size of the tumors was reduced or had disappeared completely under cystoscopic study. A new type of flexible needle was fabricated for this purpose. In 9 patients studied the total success rate was 78%. No significant side effects were seen in any of the patients.

Aged↗