Biomedical subjects
Publications and source records attributed to M Nagumo.
Cheilitis glandularis is a rare disorder characterized by swelling of the lip with hyperplasia of labial salivary glands, typically in the lower lip of adult males. A definitive cause and treatment for this disorder have not yet been established. Herein is reported a case of cheilitis glandularis affecting the upper lip with nodules, treated by surgical excision with good post-surgical results.
Between February, 1981, and April, 1989, 20 patients underwent surgical treatment of thoracoabdominal aortic aneurysms. Most of the patients were operated under temporary external bypass. For Group I and III aneurysms without reconstruction of renal arteries, a modified Crawford's graft inclusion technique was employed to shorten abdominal visceral ischemic time. This modification consists of (1) using adjuncts to perfuse the distal aorta during aortic clamp, (2) starting the first anasistomosis from the distal end of the graft, and (3) shifting the distal aortic clamp on the graft after completing the anastomosis in order to restore abdominal visceral circulation as soon as possible. For Group III and IV aneurysms with reconstruction of renal arteries as well as celiac and superior mesenteric arteries, a modified DeBakey's procedure was employed. This modification consists of (1) using the spiral opening method, (2) doing end-to-end anastomosis at the proximal aortic site, and (3) maintaining the circulation of abdominal organs and spinal cord by using adjuncts during the anastomosis of the proximal end. There were one operative death and two hospital deaths. Paraplegia developed in two cases, one of which was a ruptured case. Renal dysfunction was not found in any case. The survivors were followed from 5 to 103 months, and there was no late death. The results suggest that our modified procedures for thoracoabdominal aortic aneurysms are useful and reliable ones.
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Although the morphological features of osteosarcoma have been widely investigated, there is little information about its biochemistry. In this study, materials obtained from human calcified chondroblastic osteosarcoma were analyzed by microanalytical techniques revealing both morphological and biochemical characteristics at the same tissue site. Morphologically, tumor cells in the surface area showed atypical and mitotic figures. Hypertrophic chondroblastic cells appeared and increased in density closer to the calcified region. Almost all cells in the calcified region were hypertrophic. Biochemical analysis revealed that alkaline phosphatase activity was steeply elevated and inorganic phosphate gradually increased towards the calcified region. The spread of the calcified region was coincident with the contents of acid-soluble phosphate and calcium of the tumor. These results were similar to those found in endochondral calcification of epiphyseal growth cartilage.
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A lingual mandibular bone concavity in the central incisor region is described. The radiographic appearance of the concavity in this area is an uncommon finding. A review of the literature is presented along with the report of this case. An exact diagnosis of this lesion can be made only by surgical intervention and histologic examination. However, the axial occlusal radiographic view is thought to be helpful in diagnosing this lesion clinically.
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The structure of the carbonmonoxy-hemoglobin (COHb) photoproduct has been studied on the picosecond time scale with resonance Raman spectroscopy, by tightly focusing the 30-ps pulses of a synchronously pumped mode-locked cavitydumped dye laser on a jet stream of COHb solution. The spectrum of the photoproduct is similar to that of deoxy Hb, but the frequencies 1603 cm(-1) (depolarized), 1552 cm(-1) (anomalously polarized), and 1542 cm(-1) (depolarized) are 2-4 cm(-1) lower than those of deoxy Hb. Similar low frequencies are observed for a species believed to be the bis-tetrahydrofuran adduct of Fe(II) octaethylporphyrin, containing in-plane high-spin Fe(II). These results indicate that in the COHb photoproduct the Fe(II) is already high-spin but is closer to the heme plane than in deoxy Hb. Photodissociation from a quintet ligand-field excited state of COHb is suggested. The frequency shifts relative to deoxy Hb persist when the laser pulses are lengthened to 20 ns. The apparently slow relaxation to the fully out-of-plane heme conformation of deoxy Hb is suggested to be associated with change of the globin tertiary structure.
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