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Biomedical subjects

M Nagel

Publications and source records attributed to M Nagel.

139 records · Page 8Linked to original sources
PubMedDate not supplied

[Nocturnal changes in cortisol, catecholamines, cAMP and histamine in children with nocturnal bronchial asthma and in healthy children].

We analyzed the concentration of plasma epinephrine, norepinephrine, dopamine and C-AMP and urinary cortisol, histamine and creatinine in 28 children over a period from 4 p.m. to 8 a.m. 15 children were suffering from nocturnal asthma, 13 had no asthma problems. The cortisol-levels of both, the asthmatic and the healthy children were almost identical, the minimum cortisol-concentrations were found at 8 p.m. The concentration of plasma epinephrine in the asthmatic children was significantly higher than in the control group. Both groups showed minimum levels at 12 p.m. Plasma norepinephrine showed a continuous course with a raise in the early morning hours in both groups. Children without asthma had a continuous decrease of norepinephrine during the sleeping period and an increase in the early morning. Dopamine was significantly lower in the asthmatics. C-AMP was also on a lower level, but the difference between both groups was not significant. Histamine showed an extreme variability in the asthmatic children and was on higher levels during the whole period compared to the control group. The raised epinephrine levels in children with nocturnal asthma could be understood as compensation to a dysfunction of the receptor-transducer-adenylcyclase-complex of beta 2-receptors. A reduction of beta 2-receptors by anti-asthmatic therapy could also be responsible for these epinephrine levels. The significant difference in dopamine levels between children with and without nocturnal asthma is poorly understood. The increase of epinephrine and the decrease of dopamine could be caused by a modulated synthesis of catecholamines in children suffering from nocturnal asthma.

Adolescent↗
PubMedDate not supplied

Glutamate dehydrogenase from Medicago sativa L., purification and comparative kinetic studies of the organ-specific multiple forms.

NAD-specific glutamate dehydrogenase [L-glutamate: NAD+ oxidoreductase (deaminating) EC 1.4.1.2] from Medicago sativa constitutes organ-specific patterns of isoenzymes. The isoenzyme-patterns of seeds (GDH-I) and roots (GDH-II) were purified 1520-fold and 92-fold, respectively. All isoenzymes of both patterns remain stable throughout the purification procedures. Isoenzyme a7, the only isoenzyme common to both patterns was isolated from the GDH-I pattern. The three enzyme preparations were found to be identical in pH optima, substrate specificity and general kinetic properties. A comparative kinetic analysis revealed no pronounced differences between the various kinetic constants evaluated for the three enzyme preparations. Furthermore an identical order of substrate binding and product release could be established. Both initial rate measurements and product inhibition studies are consistent with an ordered ternary-binary kinetic mechanism. The results suggest that tissue-specific enzyme multiplicity of plant glutamate dehydrogenase is not related to differences in general or kinetic properties.

Glutamate Dehydrogenase↗
PubMedDate not supplied

Six ways to establish a Web presence.

Obtaining a Web presence may seem like a daunting task to many physicians. It's not, however. Because the Internet is quickly becoming the Yellow Pages of the 21st century, physicians without a Web site will not be able to be located by potential patients. This article provides information on six relatively simple and inexpensive methods that can be used to create a Web site, including: a personal Web page through Internet service providers; AMA Physicians Select; Medscape; a dot com biz card through Network Solutions; your own creation of a site; and a site created by a professional Web designer.

Guidelines as Topic↗
PubMedDate not supplied

[Intra- and sub-peritoneal effusions of barium. A report on 16 cases (author's transl)].

The authors report 16 cases of intra or retro-peritoneal effusion of barium due to colorectal or gastroduodenal perforations. Possible mechanisms and the consequences of barium loss are discussed. Treatment must be directed towards repair of the visceral perforation, usually in the colon or rectum, employing exteriorization or resection but without initial anastomisis, and must treat associated peritonitis by very careful extensive cleaning of the peritoneal cavity. In certain well-defined cases, sub-peritoneal perforation can be treated conservatively. The high mortality rate of about 40% can be explained by the particular type of bacterial potentiation due to barium sulfate. Preventive measures are outlined, including the use of water soluble contrast media in some selected cases.

Aged↗
PubMedDate not supplied

[Cancer of the breast in males].

Between 1982 and 1990, 1027 women and 13 men were operated upon for cancer of the breast. Analysis failed to show any difference with sex for age, localization or symptomatology. Distribution by stage, as defined by the U.I.C.C., showed a higher incidence of stage III in the men and of stage II in the women. Treatment consisted of a modified Patey type radical mastectomy in the men, a more limited intervention being applied in 20% of the women. After a mean follow up of 62 months, none of the men had died of their breast cancer. The recurrence rate was 16%. Results in this series and in those reported in the literature emphasize the decisive prognostic value of primary surgical treatment. Complementary hormone therapy with tamoxifen is particularly indicated, since 90% of the patients had positive estrogen hormone receptors.

Adult↗