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Biomedical subjects

M Nagashima

Publications and source records attributed to M Nagashima.

At least 325 records · Page 18Linked to original sources
PubMed1978

So-called multicentric pigmented Bowen's disease. Report of a case and a possible etiologic role of human papilloma virus.

Multicentric pigmented Bowen's disease (MPBD) is a bowenoid atypia in the genitocrural region with peculiar clinical appearances. A 36-year-old Japanese female patient showed a variety of lesions. Clinically the lesions on the external genitalia consisted of brown-black papillomatous eruptions, black discrete or confluent papules, and whitish macerated papules. Histologically only black papules showed bowenoid atypia, but whitish papules also showed transient bowenoid atypia. Electron microscopically, in all three kinds of the lesions, spherical particles with a diameter of about 50 nm were scattered or gathered together in the nuclei of the keratinocytes beneath the horny layer. These particles were morphologically similar to human papilloma virus. Based upon clinical, histologic and electron microscopic observations, MPBD may be regarded as a new entity, and a term such as multicentric pigmented viral papulosis may be rather preferable than MPBD.

Adolescent↗
PubMed1977

Corynecin (chloramphenicol analogs) fermentation studies: selective production of Corynecin I by Corynebacterium hydrocarboclastus grown on acetate.

Corynebacterium hydrocarboclastus KY 8835 grew in the acetate medium and accumulated 28mM Corynecins which was the highest production yield among the processes using various carbon sources. Selective production of Corynecin I (over 90% of all Corynecins), which had been desired for increase of the product yield, was achieved in this acetate medium. To keep the concentration of acetate, ammonium, and phosphate ions in the optimum range throughout the fermentation, a solution containing CH2COOH (50%), CH3COONH4 (9%), and KH2PO4 (0.2%) was fed continuously to the culture medium as the pH controlling agent. The addition of KCl (1%) and NaCl (1%) to the medium at 12 hr after inoculation stimulated the production of Corynecins.

Acetates↗
PubMed1977

The effect of atropine on ventriculoatrial conduction during ventricular pacing in patients with and without Wolff-Parkinson-White syndrome.

Electrophysiological studies were performed in five patients, two with the three without Wolff-Parkinson-White (WPW) syndrome. In the former patients group, the paroxysmal supraventricular tachycardia (PSVT) was concluded to reflect the circus movement utilizing the normal atrioventricular (A-V) conduction system for antegrade conduction and the Kent bundle for the retrograde conduction. Ventriculoatrial conduction time (VACT) was measured during ventricular pacing before and after the administration of atropine sulfate. In patients without WPW syndrome, the VACT prolonged and subsequently second degree ventriculoatrial block developed when the pacing rate was increased progressively and atropine facilitated the retrograde conduction, suggesting the ventriculoatrial conduction took place via the normal A-V pathway. In contrast, the VACT in patients with WPW syndrome remained unchanged during ventricular pacing at rates of 145/min and more before and after atropine, indicating the retrograde conduction was taking place through the Kent bundle. It is discussed that the analysis of the VACT before and after atropine serves as an aid to differentiate the underlying mechanisms of PSVT in patients with WPW syndrome.

Adult↗