Biomedical subjects
Publications and source records attributed to M N Puzin.
The new integral coefficient between free-radicals oxidation (FRO) and antioxidant defense (AOD) during periodontitis is offered. This "residual" index may be used for evaluation of the decrease or increase in the balance between FRO and AOD in different fluids and organs under different conditions.
The status of the principal hormonal systems has been examined in women with generalized periodontitis. Thyroid, adrenohypophyseal, sympathoadrenal, and gonadal hormones were studied. Statistical processing of the results revealed excessive shifts in all hormonal systems and at the inter-system level. A concept explaining the causes of the detected disorders is proposed.
Biopsy of the periodontal tissues was carried out in 29 patients with chronic generalized periodontitis in order to detect sex steroid receptors. Estrogen receptors in different levels were found in 58.6% of biopsy specimens. This implies that the trophic effect of sex steroids on the periodontium should not be ruled out.
Analysis of the function of the nervous system, based on clinical, neurological, and psychological studies in 78 patients with generalized periodontitis, revealed central regulation disorders without signs of organic lesions of the brain in 76% patients. The authors claim that stress and a high level of personal anxiety may be responsible for the development of these disorders, which was confirmed by the results of psychological testing.
Presents analysis of the status of different levels of autonomic innervation in patients with generalized periodontitis. Sympathetic activation at both suprasegmentary and segmentary levels revealed in all the patients is a pathogenetic component in the disease development. A stable correlation has been detected between the degree of segmentary sympathetic activation and severity of generalized periodontitis.
The MMPI test, Hornblow and Kidson's visual-analog anxiety scale and two types of the painful "questionnaires" suggested by the authors were used to examine the status of emotional personality sphere in 61 patients with prosopalgias due to typical trigeminal neuralgia (n = 39), dental plexalgia (n = 13) and pulpitis (n = 9). It has been revealed that patients with typical trigeminal neuralgia demonstrate the predominance of the depressive syndrome, whereas dental plexalgia is mostly characterized by anxiety. Analysis of the semantic tests is very instrumental in helping the physician to deepen the idea of the structure of subjective sensations in facial pain. Meanwhile the indicators of the "daily pain scale" promote administration of the drugs from the standpoint of chronotherapy.
The paper relates the general principles of the treatment of trigeminal neuralgia by acupuncture. The authors' own research data are provided.
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Cluster headache is a disputable and ill-defined problem of current neurology. The authors review data available on etiology, mechanisms of pathogenesis and therapy with special emphasis on biochemical and immunological disturbances; discuss nosology of the disease in the light of newly obtained evidence on its immunological aspects. An overall table of clinically justified treatments is presented.
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The authors describe the results of immunological examination of patients suffering from vegetative prosopalgias. A study was made of the initial status of immunity and of its dynamics after treatment. The majority of patients manifested an increase of immunoglobulin A concentration and activation of local humoral immunity. The treatment brought about a reduction of immunoglobulin A concentration in blood serum.
The authors describe a new method of the treatment of patients with trigeminal neuralgias using electroconvulsive therapy. The method is based on the increase of beta-endorphin concentration as a result of electroconvulsive treatment. The treatment of 12 patients in accordance with the suggested method provided beneficial results and significant enhancement of the efficacy of therapy as compared to patients undergoing conventional treatment.
The authors provide the results of an analysis of the interrelation between the immunologic and biochemical parameters in 6 groups of patients suffering from facial pains or headaches (a total of 153 patients). Significant correlations were revealed in the patients' groups with trigeminal neuralgia and periodic migrainous Horton's neuralgia. The main attention was concentrated on the following parameters: IgA in the serum, secretory IgA in the patients' saliva, % CD4 of lymphocytes and histamine concentration in the peripheral blood, concentration of beta-endorphin in the plasma, catecholamine content in the urine.
Altogether 85 patients with the painful syndromes in the facial and head areas were examined for secretion and transport of testosterone, the main androgen occurring in the body of adult man, by the blood proteins globulin- and albumin-binding sex steroids. All the women examined were in the menopause. The majority of the patients manifested hyperandrogenemia: a decrease in the concentration of sex steroids-binding globulin, rise of total testosterone and its free fraction in the blood serum as well as increase of the index of free androgens. Approaches to the correction of the revealed abnormalities and the role played by those abnormalities in the pathogenesis of the above-indicated diseases are under discussion.
Somatosensory evoked potentials, biochemical, immunological, pharmacokinetic and psychological research methods were used to examine 308 patients suffering from neuralgia of the trigeminal and glossopharyngeal nerves, neuropathy of the trigeminal nerve, neuralgias of the face and painful dysfunction of the temporomandibular articulation. New mechanisms of the pathogenesis of the diseases indicated were revealed. That made it possible to improve and devise new treatment methods.
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Serotonin levels in patients with trigeminal neuralgia were studied according to the pain syndrome. The results evidence normalization of the blood serotonin concentration, possibly due to a favourable effect of therapy on serotonin metabolism, which reflects activation and optimization of the gate system for pain control.
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