Search PubMed⌕ Search

Biomedical subjects

M N Mehta

Publications and source records attributed to M N Mehta.

At least 37 records · Page 2Linked to original sources
PubMed1987

Increased sensitivity of triiodothyronine antibodies for radioimmunoassay after removal of endogenous antigen by simple laboratory procedures.

Conventionally produced antibodies against triiodothyronine (T3) are known to possess high amounts of endogenously produced T3 associated with them. We felt that such antibodies would work better for T3 radioimmunoassay (RIA) after prior removal of the antigen. With this in view, we attempted dissociation and subsequent removal of T3 from antisera by two different methods, viz. dialysis and alcohol extraction. It was possible to remove T3 to an extent of 77% by alcohol extraction and 60% by dialysis. Resultant antisera fail to demonstrate any increase in the titre. However, when standard curves were generated using these antisera, the assays became more sensitive and it was possible to detect T3 in concentrations as low as 6.25 pg. The affinity constants of these antisera calculated from the respective Scatchard plots were found to have increased after both dialysis treatment was well as alcohol extraction. This was thought to be due to rendering some of the high affinity binding sites on the antibodies free of antigen after treatment. Serum T3 levels were measured in 68 patients with various thyroid status using both treated as well as untreated antiserum. The difference between the average values of serum T3 concentration estimated using various antisera before and after the treatment was not statistically significant. Our results suggested that a simple procedure like stripping of antigen from antibodies could be of help for acquiring high affinity and high sensitivity antibodies for this purpose.

Antibodies↗
PubMed1986

Comparison of rice water, rice electrolyte solution, and glucose electrolyte solution in the management of infantile diarrhoea.

150 infants aged under 6 months and admitted to hospital with acute gastroenteritis were treated with rice water (RW), rice-based electrolyte solution (RES), and the glucose electrolyte solution (GES) recommended by the World Health Organisation. Two-thirds of the patients were moderately dehydrated and only 8% had positive stool culture. Vomiting, present in 11%, did not interfere with successful oral rehydration. Before treatment serum electrolytes and other biochemical variables were similar in the three groups. After 48 h of treatment the blood urea nitrogen and serum creatinine were lower (p less than 0.05) in the RW and RES group than in the GES group. Serum potassium was also lower in the RW than in the RES group. RW and RES were superior to GES in reducing the frequency and volume of stool output and in producing weight gain.

Acute Disease↗
PubMed1985

Child labor in Bombay.

Of the world's largest child labor force in India, Bombay has over 30,000 working children, most of them migrants. In a prospective study of 73 working children from a part of Dharavi, the biggest slum in Asia, 68% were working as hotel boys; 22% had started working before their 10th birthday, a large number doing so to increase the family income, but earning less than Rs. 100 ($11) per month. Forty percent worked more than 12 hours a day and only 16% continued schooling. Two-thirds depended entirely on their employers for food which was adequate and no child in the study was malnourished. Overall incidence of anemia and vitamin deficiency was 10% each. Only 7% had ailments related to their occupation. Because this was a cross-sectional study no conclusions can be drawn regarding long term and residual effects. Preventing children from working is likely to make worse their own as well as their families' problems unless substitute sources of income or welfare are available. Legal protection and other services near their working places are essential for those who have to work.

Adolescent↗
PubMed1983

Adoptions: follow-up from an orphanage in Bombay.

The practice of adoption, though long accepted as a social phenomenon, is only recently gaining popularity in India. Due to the paucity of adequate follow-ups, evaluation of these adopted children is incomplete. For the purpose of studying the well-being of these children after adoption, they were followed-up at the various places, i.e., orphanages, institutions, juvenile courts and adoption agencies, responsible for their care. One hundred sixty children, 63 boys and 97 girls, adopted from an orphanage in the vicinity of our hospital over a period of 13 years are included in this study. There were 104 local and 56 foreign adoptions. Due to sociocultural background in Indian adoptions, males were preferred; whereas the international adoptions mostly depended on human considerations without any specific preference for the sex of the child. On follow-up, all children except three were reported to be physically healthy and well-adjusted emotionally in the new family, and well accepted by the society. Although adoption is not the only solution for an abandoned child, it may open some avenues for the betterment of socially deserted and deprived children.

Adoption↗
PubMed1982

Physical abuse of abandoned children in India.

Child abuse and neglect, though existing in India, has not come to light because of underlying social constraints like poverty, malnutrition and infection. With an intention to study the problem of physical abuse in neglected children, patients admitted to the pediatric wards of our institution, predominantly with some form of physical abuse were specifically looked for from January 1976 onwards. Over a period of 4 1/2 years, 18 such cases were encountered. Most of the babies were less than four weeks of age, were predominantly females, were quite often premature or malnourished, and rarely had a physical deformity. These babies were deserted and later were found by police or social workers in gutters, dustbins, garbage tins, railway platforms, etc. The spectrum of abuse and injuries included newborn babies with intact placenta, at times lacerated, strangling marks on the throat, multiple bruises, bleeding from the umbilicus, avulsion of the scalp with severe bleeding, shock as a result of environmental stress (i.e., hypothermia), evidence of infection, rat bite marks, and fractures. The morbidity was very high, ultimately resulting in 88.9% mortality over varying periods of time, maximum survival being 22 days. The motive behind this abuse always was an unwanted baby.

Child↗