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Biomedical subjects

M N Lowenthal

Publications and source records attributed to M N Lowenthal.

At least 19 recordsLinked to original sources
PubMed1998

Severe, diffuse osteosclerosis: A new manifestation of transitional cell carcinoma of the urinary bladder.

A 56 year-old man with a 2-year history of transitional-cell carcinoma of the urinary bladder presented with back pain and diffuse radiological osteosclerosis. Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin. Serum acid phosphatase and prostatic-specific antigen (PSA) were normal. Serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were just below the normal limit and parathyroid hormone was moderately elevated. A transiliac bone biopsy specimen revealed expanded bone trabeculae, abundance of osteoid-covered surfaces, and heavy metastatic spread. To the best of our knowledge, this is the first description of the association of osteosclerosis and metastatic transitional-cell carcinoma of the bladder.

Bone and Bones↗
PubMed1996

Megaloblastosis.

Explore the source record for details and available documents.

Humans↗
PubMed1996

Factors related to successful rehabilitation after hip fracture: a case-control study.

A case-control study was performed to evaluate factors associated with successful rehabilitation in elderly patients who sustained hip fractures. All 170 patients with fractured hips hospitalized in the geriatrics ward of the Soroka Medical Center in Beer-Sheva, Israel between 1987 and 1991 were studied. Success of rehabilitation was determined by staff evaluation of the patient's ability to walk and perform activities of daily living. The independent variables, including sociodemographic and medical variables, and mental and functional assessments, were assessed by chart reviews, staff evaluation and mental tests. One-hundred and twenty-nine patients (75.9%) were successfully rehabilitated. A normal mental state (p < 0.0001), female gender (p < 0.02) and absence of diabetes mellitus (p < 0.008) were associated significantly with successful rehabilitation.

Activities of Daily Living↗
PubMed1994

Demographic aspects of Paget's disease of bone in the Negev of southern Israel.

In a mainly retrospective but partly prospective survey of the period 1968-1993 in southern Israel, 61 cases of Paget's disease of bone were identified. Fifty six percent were of non-Afro-Asian origin and 44% originated from Afro-Asia, which is approximately the inverse of the ratio in the local general population. The largest single groups from non-Afro-Asia and Afro-Asia originated, from Romania and Tunisia, respectively, and Australia and Argentina were also disproportionately prominent as countries of origin. Israel itself was the origin of few patients. All the patients were Jews except for one Bedouin Arab, which is far different from the distribution of Bedouins and Jews in both the surveyed area and the hospital population. The differences between these groups numerically and against the background local population may well have been statistically significant had the circumstances enabled greater randomness in the collection of the data analyzed. It is surmised that in southern Israel the prevalence of Paget's disease of bone is about 1%, similar to that in southern Europe.

Africa↗
PubMed1994

Osteomalacia in Bedouin women of the Negev.

In a retrospective survey of hospital admissions over the years 1980-89, primary nutritional osteomalacia was diagnosed in 20 patients, all of whom were Bedouin Arab women. Every patient suffered from bone pain and proximal muscle weakness, and fixed skeletal deformities were common. Mean serum alkaline phosphatase levels were mean +/- SE 492 +/- 72 (reference range 30-125 IU/ml). Mean 25-hydroxyvitamin D levels (in 12 cases) were 4.05 +/- 0.66 ng/ml (Bedouin and Jewish female reference levels 15.1 +/- 2.6 and 32.3 +/- 3.3) respectively); in 9 of these 12 cases 24,25-dihydroxyvitamin D levels were 1.54 +/- 0.51 ng/ml (Bedouin and Jewish reference levels 0.66 +/- 0.1 and 2.44 +/- 0.29 respectively); and 1,25-dihydroxyvitamin D levels were 49.3 +/- 10.04 pg/ml (Bedouin and Jewish reference levels 83.6 +/- 11.3 and 98.6 +/- 12.3 respectively). This investigation shows that primary nutritional osteomalacia, a preventable disease, still occurs, causes severe morbidity and may be a manifestation of endemic subclinical vitamin D malnutrition in the Bedouin community in the Negev.

Adolescent↗