Search PubMed⌕ Search

Biomedical subjects

M N Lebedeva

Publications and source records attributed to M N Lebedeva.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Tanfelam: synthesis, study of ovicidal activity, and acute toxicity].

The papers describes the synthesis of N-(2-piperidinoethyl)-N-tosyl-n-anisidine (Tanfelam) which showed a 100% ovicidal activity when tested by the Harada and Mori methods (in vitro inhibited N.brasiliensis hatching and development test). Tanfelam has been transferred for in-depth tests.

Animals↗
PubMedDate not supplied

[Comparative biopharmaceutical study of tegalide].

The investigations have indicated a great influence of pharmaceutical factors on the pharmacokinetics of tegalide. The agent as tablets has a higher bioavailability than its substance. The high bioavailability of tegalide tablets appears to be associated with the presence of auxiliaries in them, which enhance the magnitude of the agent's absorption. Differences in the shelf lives of tablets affect their bioavailability. In this connection, the shelf life must be limited in terms of the pharmacological data presented.

Absorption↗
PubMedDate not supplied

[The pharmacokinetics of medamine and its solid polymeric form (medapek) in experimental larval alveolar echinococcosis in cotton rats].

Our study has shown that after single administration of its substance or its polymer formulation, medamine rapidly absorbs into blood, by penetrating into the host's viscera and tissues and parasitic larvocysts and excretes from the experimental animals' body at hour 24. Examining the distribution of medamine in the viscera and tissues has revealed that it penetrates into the rat viscera and tissue with blood and accumulated in the tissues. At the same time medamine given as a substance accumulates more in the excretory organs and medapec retains in the muscle tissue and brain longer. Medapec shows higher maximum concentrations at lower values of the pharmacokinetic curve area. Noticeable accumulation of medamine in the larvocysts of experimental animals confirms its chemotherapeutical activity.

Administration, Oral↗
PubMedDate not supplied

[Marketing study of the Russian market of anthelmintics. Assortment analysis].

The range of anthelmintics was studied at the first stage of marketing research. It has shown that there is a small number of their synonyms, a wide range of manufacturing countries, and a predominance of anthelmintics as tablets. Import anthelmintics have been prevalent on the market. However, there is a tendency for the share of anthelminitics made in Russia to increase, which will provide an indubitable economic effect while making health-promoting measures and supporting Russian pharmaceutical industry.

Anthelmintics↗
PubMedDate not supplied

[The search for new antiparasitic agents. 11. The acute toxicity and anticestodal activity of the new anthelmintic Tizanox compared with Azinox].

A synthesis is described and the results of toxicological trial of the potential anthelmintic agent G-1587 are presented. The agent is 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-2H-[1, 2,5] thiadiazino [3,2-a] isoquinoline-4,4-dioxide. The agent was shown to have a low toxicity, the maximal sublethal dose for mice being 4.0 g/kg when given per os.

Animals↗
PubMedDate not supplied

[Experimental rationale for the use of medapec as the drug of choice in treating echinococcosis].

The dosage form of medamine-medapec was found to have a high antiechinococcal activity in experiments on laboratory animals. Its efficacy was shown in treating larval alveolar echinococciasis in mice and cotton rats with different doses and courses as compared with medamine and albendazole. It was ascertained that for its high larvicidal activity, medapec should be given to animals regularly during a day. The daily dose of the drug should be gradually increased. In complying with these conditions, the duration of effective courses of therapy drastically reduces.

Administration, Oral↗
PubMedDate not supplied

[Activity of the anthelmintic agent trichlorophen on the models of human helminthiasis].

Trials of trichlorophen have shown its high efficacy on models of cestode infections: hymenolepiasis (at the adult and cysticercoid stages of development on three types of animals: outbred albino mice, albino rats and golden hamsters), preimaginal echinococciasis alveolaris, larval alveolar echinococciasis (at the early stage of development of the parasite in experiments on cotton rats). The high nematodical activity of trichlorophen was first found on models of trichocephaliasis in DBA/2y mice, nippostrongyloidiasis (in in vitro experiments), and aspiculuriasis in outbred mice. The agent proved to be ineffective at the tissue developmental stage of Hymenolepsis nana (H. nana), the dwarf tapeworm, in albino mice, during experimental opisthorchiasis in golden hamsters. It showed a low efficacy in treating trichinosis in outbred albino mice. Unlike carbamatebenzimidazoles, trichlorophen was inactive at the tissue stage of H. nana; it exerted no effects on the eggs of a dwarf tapeworm in trichinosis. Trichlorophen was also inactive in treating experimental opisthorchiasis in golden hamsters.

Administration, Oral↗
PubMedDate not supplied

[Efficacy of the Russian anthelmintic agent trichlorophen].

Experiments have established the high efficacy of combinations of the micronized dosage form of trichlorophen, with albendazole or medamine in treating trichocephaliasis (its causative agent being Trichocephalus muris) in DBA/2st mice and that of trichlorophen in combination with azinox or fenasal in outbred albino mice with hymenolepiasis (its causative agent being Hymenolepis nana). These combinations are promising in treating patients with cestodosis and nemadosis, respectively.

Administration, Oral↗
PubMedDate not supplied

[The search for new antiparasitic agents. 10. The synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine)].

Synthesis is described and acute toxicity and antimalaria action is studied in new derivatives of quinoline and benzo(g)quinoline containing a 4-(4-alkylpiperazinyl-1)phenylamine substitute. Only the derivatives of benzo(g)quinoline were found to have a high antimalaria effect and to have advantages over the standard agent chloroquine on their tolerance and protective action. One of the compounds, 4-[4-(4-ethylpiperazinyl-1)phenylamino] benzo(g)quinoline, named QUINOPRAZINE, showed some action against Plasmodium berghei chloroquine--resistant infection (isolate LN-K65). This agent was elected for further tests.

Animals↗