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Biomedical subjects

M N Hart

Publications and source records attributed to M N Hart.

At least 91 records · Page 5Linked to original sources
PubMed1977

Thrombotic thrombocytopenic purpura in a child with Alexander's disease.

Thrombocytopenic purpura developed in a 14-year-old boy with Alexander's disease; he died. The proximity of Rosenthal fibers to small vessels in the brain, the presence of perivascular lymphocytes in the brain, and the presence of complement in renal arterioles suggest that the Rosenthal fibers could have injured the endothelium-basement membrane resulting in an immune response triggering the thrombotic thrombocytopenic purpura.

Brain↗
PubMed1975

Haemorrhagic and perivenous encephalitis: a clinical-pathological review of 38 cases.

Clinical and pathological data from eight cases of acute haemorrhagic leucoencephalitis (AHL) confirm the previously documented devastating features of this disease. Data from 30 cases of perivenous encephalitis (PVE) associated with viral diseases reveal pathological changes ranging from lymphocytic cuffing of vessels to severe vasculitis similar to the vasculitis of AHL. Relatively few cases show demyelination as a prominent feature. The pathological changes are unrelated to the type of underlying disease with the exception that the pathology of 'post-rubella' encephalitis tends to be mild. Two cases of rubeola and two of mumps showed viral nodules in the cortex, raising the possibility of direct viral invasion of tissue. Allowing for species differences, these changes are analogous to the pathological features of experimental allergic encephalitis (EAE); with the various pathological changes of PVE paralleling the features of ordinary EAE, while the changes of AHL and the severe cases of PVE strongly resemble hyperacute EAE.

Acute Disease↗
PubMed1975

Perivascular anoxia-ischemia lesions in the human brain.

The clinical and pathologic data are presented on three patients who had clinical anoxia-ischemia in combination with serum hyperosmolality. The pathologic lesions consisted of perivascular necrosis, predominantly involving small vessels in the cerebral cortex. No intraluminal thromboembolic material was found in any of the vessels. The lesions are reminiscent of "no-reflow" lesions seen in experimental animals rendered ischemic.

Adult↗
PubMed1974

Mixed gliomas.

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Adolescent↗
PubMed1973

Hyaline globules.

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Antibodies↗
PubMedDate not supplied

Human cytomegalovirus nucleic acids in tissues from congenitally infected infants.

In situ nucleic acid hybridization methods were used to study autopsy tissues from 2 infants with clinical or pathologic evidence of congenital cytomegalovirus infections: a premature infant with multiple congenital malformations and inclusion bodies in several organs and an infant with culture-proved symptomatic congenital cytomegalovirus infection. Cytomegalovirus nucleic acids were detected in lung, kidney, adrenal, thyroid, skin, pancreas, and anterior pituitary tissues. In the second infant, hybridization studies of neural tissues failed to reveal cytomegalovirus nucleic acids despite neuropathologic abnormalities consisting of extensive necrotizing ependymitis and periventricular cavitation.

Cytomegalovirus↗
PubMedDate not supplied

MR findings of an unusual intracranial neuroma simulating a meningioma.

We report an unusual intracranial neuroma that simulated a meningioma on CT and magnetic resonance imaging. A diagnosis of meningioma was suggested because the tumor was tentorium-based; had enlarged into both the middle and posterior fossae; contained calcification and was homogeneous and densely enhancing on contrast CT; and was isointense with brain on T1- and T2-weighted images. The tumor proved to be a schwannoma with characteristic electron microscopic findings.

Adult↗
PubMedDate not supplied

Effect of chronic hypertension and sympathetic denervation on wall/lumen ratio of cerebral vessels.

The purposes of this study were to determine whether 1) cerebral vessels undergo hypertrophy during chronic hypertension and 2) sympathetic nerves contribute to cerebral vascular changes in chronic hypertension. Morphometric studies were undertaken in stroke-prone spontaneously hypertensive rats (SP-SHR) and normotensive Wistar-Kyoto (WKY) rats. Unilateral superior cervical ganglionectomy was performed in the SP-SHR at 8 weeks of age. When the rats were approximately 13 months old, they were killed and the brain was fixed with formalin at a perfusion pressure of 80% of the rat's systolic pressure. Wall/lumen ratio was measured in approximately 1200 arteries and arterioles. In parenchymal, but not pial, cerebral vessels there was pronounced vascular hypertrophy in SP-SHR: wall/lumen ratio was 0.08 in WKY and 0.14 in SP-SHR (p < 0.05). Sympathetic denervation attenuated the development of vascular hypertrophy in SP-SHR: wall/lumen ratio was 0.14 in the innervated parenchymal vessels, and 0.10 in denervated vessels (p < 0.05). We conclude that cerebral vessels undergo hypertrophy in stroke-prone SHR and speculate that vascular hypertrophy may protect cerebral vessels by reducing wall stress in chronic hypertension. Sympathetic nerves appear to exert a trophic effect on cerebral vascular muscle in chronic hypertension.

Animals↗