Ketamine-induced rotation and its interaction with naloxone in rats.
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Amphetamine↗
Biomedical subjects
M Myslobodsky
Publications and source records attributed to M Myslobodsky.
An electrophysiological correlate of amphetamine revealed motor imbalance in albino rats.
Ten out of eleven Wistar rats displayed a reliable interhemispheric asymmetry of the secondary slow negative wave (SNW) of the visual evoked potential. A more synchronized EEG was observed on the side of facilitated SNW. The analysis of rotation directionality in the rotometer of these rats after IP (+)-amphetamine administration (1.25 mg/kg) showed that rats reliably rotated towards the side with a more facilitated SNW. It is believed that an imbalance of nigrostriatal DA content underlies the interhemispheric asymmetry of EEG and evoked potentials.
Amphetamine↗
Hemispheric asymmetry of pentamethylenetetrazol-induced wave-spike discharges and motor imbalance in rats.
An intrinsic asymmetry of nigrostriatal dopamine system postulated to be responsible for motor imbalance in normal rats (Glick et al., 1976) is believed to create asymmetry of arousal-sensitive wave-spike discharges. In the present study, bilaterally recorded pentamethylenetetrazol (PMZ)-activated wave-spike discharges were correlated with circling behavior in intact rats. Thirteen naive rats (10 male, 3 female) were implanted with electrodes symmetrically placed over the visual cortices, and their rotation directionality was assessed in the rotometer subsequent to administration of d-methamphetamine sul-ate, 1.5 mg/kg, i.p. In 9 rats a PMZ injection, 20 mg/kg, i.p., revealed asymmetric wave-spike bursts. All of them reliably rotated in the dirction opposite to the hemisphere with lower amplitude wave-spike discharges. It is believed that the nigrostriatal dopamine system plays a major role in modulating the asymmetry of wave-spike seizures. The findings are discussed as they relate to asymmetric generalized wave-spike dischanges found in certain petit mal patients.
Animals↗
Pharmacologic implications of hemispheric asymmetry.
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Auditory Perception↗
A new look at sleep position via head slant.
We investigated whether the degree of plagiocephaly (P) (head slant) would predict the particular "position of comfort" adopted prior to sleep. A marked flattening of the right occipital bone (left-dominant occipital plagiocephaly) was noted for the majority of our subjects, coupled with a tendency to prefer a right-sided "position of comfort". Two subjects exhibiting right-dominant occipital P adopted an extreme left-sided sleep position, providing further support for this relationship. We call attention to the possibility that the "position of comfort" adopted prior to sleep, may be a variable of relevance for the entire sleep cycle.
Female↗