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Biomedical subjects

M Myers

Publications and source records attributed to M Myers.

At least 127 records · Page 7Linked to original sources
PubMed1979

Assessment of coronary venous bypass graft function using krypton-81m.

Fifteen patients with intractable angina pectoris underwent coronary angiography and coronary arterial bypass graft surgery. After the operation, a continuous infusion of krypton-81m was delivered into each graft. A gamma camera and multichannel analyzer were used to record the regional myocardial distribution of perfusion provided by each graft. The disappearance of myocardial activity at the end of each infusion was used to calculate the flow per unit volume in the myocardial distribution provided by each vessel. Myocardial perfusion provided by the grafts to all the major coronary arteries were recorded individually as high spatial resolution images. Myocardial flow rates in the distribution of each graft were measured using the washout of krypton-81m. The rates were 0.5 to 2.0 ml/g per min in the 13 patients with no evidence of previous myocardial infarction. Krypton-81m was infused into grafts to the left anterior descending coronary artery in two patients with a history and electrocardiographic evidence of previous anterior myocardial infarction. The grafts provided poor perfusion to the anterior and apical portions of the ventricles. An experimental model of myocardial perfusion was used to demonstrate that the washout of krypton-81m can be used to measure flow per unit volume within or above the physiologic range.

Angina Pectoris↗
PubMed1979

Survival rates after enucleation of eyes with malignant melanoma.

We investigated the rates of mortality for several types of malignant melanomas for evidence that surgery accelerates metastasis. Additionally, we reanalyzed uveal melanoma survival rates from the Armed Forces Institute of Pathology. Our computations showed higher death rates in years two to five after diagnosis than in years one or six to ten. The same pattern of a peak mortality in the early years after diagnosis and lower rates six to ten years thereafter was seen in all tumor types studied. Our analysis of survival rates produced no evidence to alter the existing pattern of treatment for malignant melanoma of the uvea.

Eye Neoplasms↗
PubMed1976

Emphysematous gastritis in a leukemic child.

Emphysematous gastritis associated with gram-negative sepsis is described in a leukemic child on chemotherapy and steroids. Bubbly-appearing air and thickening of the gastric wall were radiographically demonstrated. This is analogous to the demonstration of air within the thickened bowel wall in necrotizing enterocolitis, which is not unusual in seriously ill leukemic children. Gastric involvement has not been previously reported.

Child↗
PubMed1976

Theophylline radioimmunoassay: synthesis of antigen and characterization of antiserum.

Antisera to theophylline (T) have been obtained by immunizing rabbits with a conjugate of 8-(3-carboxypropyl)-1,3-dimethylxanthine and bovine serum albumin. Comparison of 50% displacement values indicated good selectivity for T vs. a number of other xanthine derivatives. An analytical procedure using this antiserum can measure 200 pg of T and direct analysis of 0.1 mug/ml in plasma or 0.02 mug/ml in saliva is feasible.

Animals↗
PubMed1975

Studies on the intracisternal A-type particles in mouse plasma cell tumors: induction of maturation of the particles.

Maturation of the intracisternal A-type particle found in two mouse plasma cell tumors was induced by treating the cells in culture with IDU-DMSO or with DMSO only. Morphologically, the mature particles with electron-dense nucleoids closely resembled the mature particles described in human tumor cell lines treated in a like manner. They also closely resembled the virus that has been described in guinea pig leukemias. It was not possible to demonstrate infectivity of the mature particle, as latent intracisternal A-type particles induced by IDU were found in the mouse cells presumed to be free of virus. The biochemical studies did not show distinct new peaks of virus-specific particles in sucrose density gradients when the particles in the treated cells were compared with the particles of the untreated cells. There was a difference in the density of the particles observed in the induced cells (1.2) and those of the control cells (1.185). This may reflect the difficulty of separating mature and immature particles. Analysis of the RNA present in the particles showed that the ratio of heavy-molecular-weight RNA in activated cells to the predominant species (21S) is much greater than that in control cells. Detectable levels of enzyme activity were not found in the induced particles. This could be due to too low a concentration of particles in the preparations.

Animals↗
PubMed1975

Prophylaxis of varicella in children with neoplastic disease: comparative results with zoster immune plasma and gamma globulin.

The incidence and severity of varicella following a close family contact were evaluated in children with neoplastic diseases who received prophylaxis either with commerical gamma globulin or with zoster immune plasma, as compared to patients who did not receive any prophylaxis. In the untreated group, all 14 patients developed varicella, complicated by 1 case of encephalitis and 2 cases of fatal pneumonia. In the group of 17 patients who received 0.6-1.2 ml/kg body weight of gamma globulin, 16 developed varicella, complicated by pneumonia in 2 cases, with 1 death. In the third group of 27 patients who received 10 ml/kg body weight of zoster immune plasma (ZIP), obtained from healthy adults convalescing from herpes zoster, there were only 8 cases of varicella, all very mild. Thus, prophylaxis with ZIP significantly reduced the incidence of clinical varicella (p less than 0.01) and attenuated the severity of its course.

Antineoplastic Agents↗