Biomedical subjects

M Mydlík

Publications and source records attributed to M Mydlík.

At least 19 recordsLinked to original sources

PubMed1992

Vitamin B6 requirements in chronic renal failure.

According to our results the long-term daily oral supplementation of 6 mg vitamin B6 was sufficient for prevention of vitamin B6 deficiency in chronic renal failure, regular dialysis treatment and CAPD groups of patients. Haemodialysis and charcoal haemoperfusion have led to non-significant decrease of erythrocyte vitamin B6. A favourable effect was found of daily oral administration of 50 mg pyridoxine on electrophoretic mobility of peripheral blood lymphocytes and cellular immunity.

Adult↗

PubMed1992

[ECG Holter monitoring in patients with chronic renal failure in a long-term dialysis program].

Using the Holter method, the authors monitored for 24-hours 30 patients included in a long-term dialyzation programme during and after haemodialysis. A group of 15 patients who had during examination frequent or complex supraventricular or ventricular ectopia was compared with a group of 15 patients with sporadic ectopia. In the arrhythmic group paroxysmal supraventricular tachycardia was recorded in 33% and paroxysmal atrial fibrillation in 13%, polytopic or repetitive ventricular extrasystoles in 14%, couplets in 20% and volleys of ventricular extrasystoles or non-persisting ventricular tachycardia in 20%. Comparison of clinical laboratory and echocardiographic characteristics revealed in the arrhythmic group significantly higher mean ages of patients, higher levels of ionized serum calcium before haemodialysis, C terminal parathormone, the breadth of the interventricular septum, and the authors observed also a higher incidence of hyperechogenity of cardiac structures. On analysis of repolarization ECG changes significant asymptomatic depressions of the ST segment were found which were transient and dominated during the early posthaemodialyzation period in 11 patients of the whole group (37%).

Adult↗

PubMed1991

[Vitamin B12 and folic acid in chronic kidney failure and after kidney transplantation].

Vitamin B12 in plasma, folic acid in plasma and erythrocytes were examined in 11 patients in the polyuric stage of chronic renal failure without dialyzation treatment, in 38 patients included in a long-term dialyzation programme before and after 3 months' oral administration of folic acid--(2 X 5 mg week)--and in 23 patients after transplantation of the kidneys. In none of the examined groups vitamin B12) and folic acid deficiency in plasma was detected. A reduced folic acid level in erythrocytes, but still in the reference range, was found in patients in the long-term dialyzation programme without supplementation. Supplementation with folic acid increased its concentration in plasma 4.5 times and in red cells 5.5 times. Haemodialysis did not influence the concentration of the examined indicators in plasma and red cells. According to the recorded results it is not necessary to supplement patients in long-term dialyzation programme and after renal transplantation with vitamin B12 and folic acid, if their dietary protein intake is not restricted.

Female↗

PubMed1991

[Hemoperfusion of theophylline. An in vitro study].

The authors made 30 haemoperfusions of theophylline in vitro in a closed system, using capsules Hemasorb 800 C, Hemasorb 800 A-2 and 800 A-4. As perfusion solution they used 4 litres of aqueous solution with an osmolality of 286 mmol/kg. The theophylline concentration in solution was 282.8 +/- 5.2 mumol/l. Individual haemoperfusions lasted 5 hours. After the theophylline solution has passed across Hemasorb A-4 the concentration of the substance could be assessed at all time intervals and during the 180th minute the theophylline concentration could be detected also before entering the haemoperfusion capsule. When using Hemasorb 800 A-2, the adsorption capacity of the haemoperfusion capsule was exhausted already during the 180th minute. The assembled results suggested that the most effective theophylline haemoperfusion in vitro was obtained with Hemasorb 800 A-4 and the least effective one with Hemasorb 800 A-2. The authors recommend to use in acute intoxication with theophylline in humans haemoperfusion via Hemasorb 800 A-4.

Hemoperfusion↗

PubMed1991

Serum vitamin A, retinyl esters and vitamin E in nephrotic syndrome.

Serum vitamin A, retinyl esters and vitamin E were increased in a group of 33 patients with chronic glomerulonephritis and nephrotic syndrome without reduction of mean glomerular filtration rate. Despite hypoproteinaemia and reduced values of serum proteins with a different molecular weight, increased values of vitamin A protein carriers were found. Serum total cholesterol, LDL cholesterol, triglyceride, prebeta und beta lipoproteins were increased, HDL cholesterol was within the reference range. Direct relationships were found between serum retinyl esters and vitamin A, and between serum retinyl esters and prealbumin. Indirect relationships were detected between serum total cholesterol and total proteins, serum total cholesterol and albumin, and serum vitamin E and albumin. The increased values of vitamin A, retinyl esters as well as its protein carriers and of vitamin E were probably a manifestation of enhanced protein and lipid synthesis in the liver as a result of albumin depletion. These results show true A and E hypervitaminosis in patients with nephrotic syndrome.

Blood Proteins↗

PubMed1991

[Vitamin A and metabolic disorders of calcium and phosphorus in patients on a long-term dialysis program].

The aim of the present work was to reveal the relationship between vitamin A serum levels and some indicators of metabolic calcium and phosphorus disorders in patients in a long-term dialyzation programme. Thirty-six patients in a long-term dialyzation programme were divided into three groups. Group A comprised 11 patients who were treated for 3-9 months but without specific treatment, group B was formed by 10 patients treated for 2-5 years who were given calcium carbonate, 3 g/24 h, by the oral route for a period of six months and group C which comprised 15 patients treated for 3-10 years who were given 1 alpha, 25-dihydroxycholecalciferol (Rocaltrol), 0.25 micrograms/24 h for a period of six months. At the end of the investigation a significant rise of total calcium and serum Ca2+ occurred in all three groups of patients an a significant decrease of increased value of phosphorus, C-PTH and vitamin A in serum in groups B and C. In group A which was without treatment there was a significant increase of serum C-PTH and vitamin A after six months. The concentration of retinyl esters in serum was within the reference range of there were undetectable values throughout the investigation in all patients. A direct relationship was found between total calcium and vitamin A, alkaline phosphatase and C-PTH in serum in all 36 patients at the onset of the dialyzation programme. Moreover there was a direct relationship between C-PTH and vitamin A in groups, A, B and C at the onset of the investigation and in groups and vitamin C at the end of the investigation.(ABSTRACT TRUNCATED AT 250 WORDS)

Calcitriol↗

PubMed1990

[Vitamin B1, B2 and B6 in erythrocytes in the nephrotic syndrome].

In 19 patients with nephrotic syndrome in different diseases not associated with reduction of the glomerular filtration surface vitamin B1 was within the reference range, vitamin B2 was insignificantly and vitamin B6 significantly reduced. The concentrations of vitamins B1, B2 and B6 in red blood cells were assessed by indirect enzymatic methods and were expressed as vitamin action. Long-term six-month riboflavin supplementation (2 mg/24 h) and pyridoxine (50 mg/24 h) in seven patients improved vitamin B2 and B6 levels in erythrocytes independently on the regression of the clinical and laboratory activity of the basic disease.

Adult↗

PubMed1990

[Use of a computer for obtaining optimal serum sodium values at the end of hemodialysis].

The authors made 41 haemodialyses in 21 patients in the course of a long-term dialyzation programme, using a dialyzation monitor connected with a computer. The aim of the investigation was to achieve at the end of the six-hour haemodialysis the optimal serum sodium value of 142 mmol/l, using different ultrafiltrations (1000, 2000 and 3000 ml/6 hours). It was revealed that to obtain the optimal serum sodium level it was necessary to use in the dialyzation solution a sodium concentration of 144.9 +/- 0.2 mmol/l. The water transport from the intracellular to the extracellular fluid was typical for the distribution of total body water, regardless of the volume of ultrafiltration. The amount of removed sodium during haemodialysis depended on the sodium concentration in the dialyzation fluid and on the ultrafiltration volume. The values of the volume and clearance of sodium-free water depended on the amount of sodium eliminated into the dialyzation solution.

Female↗

PubMed1989

[The effect of sodium levels in dialysis solutions on the distribution of total body water during hemodialysis].

Thirty-seven haemodialyses with ultrafiltration were performed (3000 ml/6 hours). using three sodium concentrations (140, 145 and 150 mmol/l) in the dialysate solution in 16 hyperhydrated patients during a long-term dialysis program. The amount of eliminated sodium during haemodialysis depended on the sodium concentration in the dialysate solution. The reduction of the volume of total body water corresponded to ultrafiltration. When a sodium concentration of 150 mmol/l in the dialysate solution was used, the smallest diminution of extracellular fluid and greatest diminution of intracellular fluid was observed. At the same time the greatest transport of water from the intracellular into the extracellular fluid was recorded. A sodium concentration of 145 and 150 mmol/l in the dialysate solution gave rise to positive values of sodium-free water and of sodium-free water clearance. Sodium-free water and of sodium-free water clearance correlated directly with the sodium concentration in the dialysate solution and inversely with the amount of eliminated sodium. The patients were free from complaints during haemodialyses and no significant blood pressure changes were found. The dialysate solution with the sodium concentrations used is suitable for a long-term dialysis programme; the authors recommend, however, to use individual sodium concentrations, depending on the patient's clinical condition.

Adult↗

PubMed1979