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Biomedical subjects

M Murray

Publications and source records attributed to M Murray.

656 records · Page 37Linked to original sources
PubMedDate not supplied

Results of therapeutic bed monitoring: justification of ET nursing.

Therapeutic beds are used frequently at St. Vincent Medical Center, a 640-bed tertiary care hospital. The beds are designed to reduce body surface pressures for patients with potential for or actual pressure injury related to mechanical forces (pressure, friction, and/or shear). A monitoring system for therapeutic bed usage was initiated by the Enterostomal Therapy Department in March 1990 because of concerns about prolonged and sometimes unnecessary use of the beds. In this article, the monitoring system is described with the results after 1 year.

Beds↗
PubMedDate not supplied

In vitro formation of an inhibitory complex between an isosafrole metabolite and rat hepatic cytochrome P-450 PB-B.

A series of in vitro studies was performed, in rat liver microsomes, in which metabolite intermediate (MI) complexation of cytochrome P-450 (P-450) by the methylenedioxyphenyl compound isosafrole was related to P-450 isozyme-specific inhibition of drug oxidation. The C19-steroid androst-4-ene-3,17-dione was selected for initial study because the stereoselective hydroxylation of this substrate is specific for certain P-450s. In control microsomes only the 6 beta- and 16 beta-hydroxylations of the steroid (catalyzed, respectively, by the P-450s PCN-E and PB-B) were inhibited by isosafrole (I50 = 100 and 110 microM). In contrast, the 7 alpha- and 16 alpha-hydroxylases (P-450 UT-F- and UT-A-mediated, respectively) were refractory to inhibition. After phenobarbital (PB) induction, steroid 6 beta- and 16 beta-hydroxylase activities were again inhibited (I50 = 170 and 190 microM) but, in addition, the 16 alpha-hydroxylase pathway was also inhibited (I50 = 200 microM). Spectral studies revealed that MI complexation of P-450 in untreated microsomes was minimal but was enhanced markedly after PB induction (up to 50% of the total P-450 content complexed). Thus, it is apparent that a PB-inducible P-450 is involved in MI complex formation under these conditions. Indeed the I50 of isosafrole toward steroid 16 beta-hydroxylase activity was decreased if the inhibitor was preincubated with NADPH-fortified PB-induced microsomes prior to substrate addition; the preincubation step did not enhance the inhibition of any other steroid hydroxylase pathway by isosafrole.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Measuring nursing workload: understanding the variability.

The authors present a new multifactorial intensity and complexity of care model and meta-paradigm that is designed to examine costs, nursing work, and the variability in resource use across patients and environments. Relationships were observed among four key variables which included patient-nursing condition, medical condition, caregiver characteristics and the environment. Patient-nursing complexity and medical complexity are commonly measured by nursing diagnosis and DRG or Canadian case mix groupings (CMG) respectively. The complexities associated with the work environment had been the least previously studied factors. Environmental complexity factors include both supply and demand dimensions: scheduling and coordination of procedures, multiple and long procedures, and characteristics and composition of the caregiver team.

Adolescent↗