Search PubMed⌕ Search

Biomedical subjects

M Murase

Publications and source records attributed to M Murase.

At least 217 records · Page 12Linked to original sources
PubMed1983

[Clinical evaluation of an ampicillin suppository (KS-R1) in pediatrics].

Blood level of ampicillin (ABPC) after the administration of ABPC suppository (KS-R1) reached a peak in 15 approximately 60 minutes with the level of 300 ng/ml at a dose of 1 mg/kg/day. This level was almost the same as that after the intramuscular injection of ABPC, and higher than that after the oral administration of ABPC which were reported. The clinical effective rate (excellent and good) of KS-R1 was more the 95%, and the overall effective rate including bacteriological effect was more than 95%. It is concluded that KS-R1 is a useful drug for the treatment of bacterial infections in pediatric field.

Age Factors↗
PubMed1983

[Nonsurgical technique for removal of catheter fragments in the heart and the great vessels].

With the widespread use of intravenous polyethylene or silicone elastomer catheters for continuous infusion of fluids and drugs and monitoring central venous pressure, loss of catheter fragments into the central circulation has become an increasing problem. These catheter fragments have been removed from all areas of the right side circulatory system by various techniques not requiring thoracotomy. Many kinds of instruments for nonsurgical removal of these fragments have been utilized. The majority of them have been accomplished using a loop snare or a helical basket. As with loop snares and baskets, a free end of fragments is necessary for fragment entrapment. In this report the authors describe four cases with catheter fragments in the heart or the great vessels and a new nonsurgical technique using a "forceps with three or two grasping prongs for endoscope" for their removal. In the first case, we could remove the embolized catheter fragment without accessible free ends in the pulmonary artery by this method. This special forceps with two grasping prongs was applicable even for the infant and could be inserted through a No. 8 French Cordis catheter introducer. This method is extremely promising for removal of catheter fragments in the central circulatory system.

Adult↗
PubMed1982

Assessment of mitral valve function using a cardioplegic cannula.

A technique facilitating intraoperative assessment of the degree of mitral regurgitation during mitral reconstructive procedures is reported. During open heart procedure using cardioplegia, a cardioplegic cannula in the aortic root was inserted into the left ventricle, filling the left ventricle with cold saline, and competence of the mitral valve was assessed. This assessment of mitral regurgitation during open heart procedure was compared with the degree of mitral regurgitation by the postoperative left ventriculography. This technique was expedient, safe and helpful.

Cardiac Catheterization↗
PubMed1982

A case of bacteremia and disseminated intravascular coagulation after the conduit procedure for tetralogy of Fallot with pulmonary atresia.

A case undergoing conduit procedure for tetralogy of Fallot with pulmonary atresia was complicated postoperatively by bacteremia due to non-fermentative Gram-negative rods and by disseminated intravascular coagulation. He was able to be cured without any sequela. The patient was a 16-year-old male, who had undergone Blalock-Taussig anastomosis in his infancy. The present operation was carried out as follows: ventricular septal defect was closed with a Teflon-patch and discontinuity between the right ventricle and the pulmonary artery was corrected using a Hancock's valved conduit. Two weeks after the operation, pleural effusion in the right chest cavity was shown by a chest X-ray film. On the 32nd postoperative day, high fever with chills occurred, and subsequently developed pulmonary edema, shock and hemorrhagic tendencies with petechia. Pseudomonas aeruginosa, Flavobacterium and Alcaligenes faecalis were detected by the culture of pleural effusion. The platelet count decreased to about 10,000/microliters. Carbenicillin, tobramycin and minocycline were administered for the infection, and heparin and aprotinin were used for disseminated intravascular coagulation. By these treatments for about 6 months, the patient became well and was discharged without any sequela.

Adolescent↗
PubMed1982

[Antibacterial activities of cefotiam against various pathogens isolated from clinical materials (author's transl)].

Bacteriological evaluation was made on cefotiam (CTM), a new broad-spectrum cephalosporin antibiotic, and the following results wer obtained. 1) CTM has shown very potent antibacterial activities against Staphylococcus aureus, Escherichia coli, Edwardsiella tarda, Citrobacter intermedius, Salmonella, Klebsiella, Proteus mirabilis, Proteus rettgeri, Proteus inconstans, Yersinia enterocolitica, Aeromonas hydrophila, Plesiomonas shigelloides and Pseudomonas putrefaciens. 2) Streptococcus faecalis, Enterobacter and Proteus morganii isolated from urine, Serratia and glucose non fermentative Gram-negative bacilli except Pseudomonas putrefaciens, were almost insusceptible to cefotiam.

Bacteria↗
PubMed1982

[Concentration of sulbenicillin in human serum and myocardial tissue].

The concentration of sulbenicillin in the serum and myocardial tissue of 13 patients were determined at cardiac surgery. About 100 mg/kg of sulbenicillin were administered intravenously for 60 minutes. Right auricle resected at the vena caval cannuration was examined for myocardial tissue. The serum concentration was also examined every 30 minutes after injection, 30 minutes, 60 minutes, 90 minutes, 120 minutes and 150 minutes. Mean values of serum concentration were 213.6 micrograms/ml, 432.5 micrograms/ml, 181.6 micrograms/ml, 236.3 micrograms/ml and 101 micrograms/ml, respectively. The values determined in myocardial tissue were 146.5 micrograms/g (60 minutes), 39.2 micrograms/g (90 minutes), 66.0 micrograms/g (120 minutes) and 23.5 micrograms/g (150 minutes). The mean value of concentration ratio of sulbenicillin in myocardial tissue was 0.23 of serum concentration. The high myocardial tissue levels of sulbenicillin suggests that its use at cardiovascular surgery would protect the myocardial tissue from the bacterial infections.

Adolescent↗
PubMed1981

Central action of bradykinin (I). Electroencephalogram of bradykinin and its degradation system in rat brain.

Both in vivo and in vitro experiments were performed to elucidate the relationship between the action of bradykinin (BK) and the possibility of release of pharmacologically active fragments from BK in the rat brain. In in vivo experiments, the activities of electroencephalogram (EEG) increased immediately after the intracerebral administration of 5 nmole BK. The effect was prolonged by intracerebral pretreatment of o-phenanthroline which inhibits plasma kininases. In vitro experiments, o-phenanthroline inhibited partially purified enzyme of rat brain which released fragments of BK possessing phenylalanine, serine, proline and/or arginine as N-terminal amino acids. Only arginine and minute amounts of phenylalanine were observed after the incubation with o-phenanthroline. The evidence suggests that the inhibition of the enzyme by o-phenanthroline resulted in a prolongation of the excited phase produced by BK on the EEG and on behavior. Supporting evidence indicates that Ser-Pro containing fragments derived from BK are concerned with the sedative phase of BK which was observed after the excitative stage.

Animals↗
PubMed1981

[Clinical studies of cefoxitin in the pediatric field (author's transl)].

1. The in vitro antibacterial activity of cefoxitin was nearly equal to that of CEZ and CET against the 6 species of clinically isolated strains. Cefoxitin, furthermore, had an antibacterial activity against the strains of P. morganii resistant to CEZ and CET. 2. Cefoxitin was applied to a total of 17 patients including 6 cases of bronchitis, 5 of pneumonia, 2 of enteritis, and 1 each of pharyngitis, laryngitis, sinusitis and lymphadenitis. The results showed an efficacy rate of 88%. In the 6 patients from whom the isolation of pathogenic organisms was possible, the bacteriological response to cefoxitin was appreciable the efficacy rate being 83%. Thus, it is considered that cefoxitin also has a significant antibacterial activity in vivo. 3. As to the side effects following the administration of cefoxitin, urticaria-like eruption was observed in 1 case, and an elevation of transaminase in another. These findings, however, became normal soon after discontinuation of cefoxitin treatment.

Adolescent↗