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Biomedical subjects

M Munteanu

Publications and source records attributed to M Munteanu.

At least 37 records · Page 2Linked to original sources

[Myelinated nerve fibers associated with cilioretinal artery occlusion].

Although the myelinated nerve fibers are considered as benign, cases associated with retinal vascular abnormalities (telangiectasis, neovascularization, vascular occlusions) have recently been reported, suggesting a possible pathogenic correlation between these elements. Our observation presents a 44-year-old patient, with a sudden decrease of visual acuity in the right eye, discal and peridiscal myelinated nerve fibers, associated with cilioretinal artery occlusion. The general clinical and laboratory examination, except for a drug stabilized arterial hypertension, did not reveal other local or general embolic factors. One year later, the decrease in visual acuity had remained unchanged and the area of the myelinated nerve fibers had diminished. Based on the association between the myelinated nerve fibers, the cilioretinal artery occlusion, the young age of the patient, and the absence of other local or general embolic factors, we consider there is a possible pathogenic correlation between these elements. The action of the myelinated nerve fibers can be explained by a mechanical compression, with the disruption of the cilioretinal artery route, a structurally vulnerable artery.

Adult↗

[A peculiar case of microcystic macular edema].

We present a case of microcytic macular oedema, in a patient 60 years old, suffering of systemic lupus erythematosus. The specific feature of the case is the presence of the microcystic macular oedema, as the only form of manifestation of the retinal lesions in the posterior pole. The diagnosis, etiopathogenicity and treatment are discussed.

Diagnosis, Differential↗

[Serpiginous choroiditis - clinical study].

The work shows a retrospective study a period of 12 years, on a number of 34 cases of serpiginous choroiditis. The average age of the patients was 36 years (29-68). The start of the illness was juxtapapillary in 99.1% and macular on 5.9% of the cases. The bilateralism was present in all the cases (delayed start), and the visual acuity was strongly affected in macular localizations. The ophthalmoscopical and angiofluorographic aspect is specific for all the evolutive phases, and the extension of the lesions is made by means of pseudopodia. problems of differential diagnosis, pathogenesis (hereditary, inflammatory, vascular) are discussed. We have obtained satisfying results by triple association of immunosuppressants: azathioprine, cyclosporins and prednisone.

Adult↗

[Myelinated nerve fibers associated with juxtapapillary haemorrhages].

The myelinated nerve fibers (MNF) are o congenital anomaly characterized by the extension of the myelinisation process anterior from the lamina cribosa. The incidence of myelinated nerve fibers is 0.3-0.6% in patients and 0.54% in eyes from autopsies. Although these represent benign lesion, rarely are associated with retinal abnormalities: vascular abnormality (retinal telangiectasis, cranial-facial lesions, coloboma of the iris, keratoconus, myopia/strabismus, amblyopia). Myelinated nerve fibers asSociated with juxtapapillary haemorrhages was not reported in the available literature. We describe the clinical findings and diagnostic particularities of myelinated retinal nerve fibers associated with juxtapapillary haemorrhages in a personal case. An 40-year-old woman was referred for unilateral papillary abnormalities. The diagnosis was myelinated retinal nerve fibers as white striated patches with feathery edges, associated with two juxtapapillary haemorrhages. The clinical and pathogenic features are discussed. Based on the association between the myelinated nerve fibers, the juxtapapillary haemorrhages there is a possible pathogenic correlation between these elements. The action of the myelinated nerve fibers can be explained by a mechanical compression, with the disruption of the retinal artery, a structural vulnerable artery.

Adult↗

[Papilloedema and POEMS syndrome].

POEMS syndrome stands for the first letter of the words: polyneuropathy (P), organomegaly (O), endocrinopathy (E), monoclonal component (M), changes of the tegument (S-skin). In 33-84% of the cases, chronic bilateral papilloedema is associated with the syndrome. The disease is a multisystem disorder, a plasma cell dyscrasia being present, often associated with Castleman disease. Inflammatory cytokines, endothelial vascular growth factor and human herpes virus-8 are thought to play an important role in pathogenesis. This summary is about a 16 year old female patient, where the diagnosis of POEMS syndrome was elaborated based on the systematization of the clinical symptomatology, developed over a long period of time. Based on the latest data from literature, peculiarities of diagnosis, pathogenesis and therapy of the disease are being discussed.

Adolescent↗

[A familial case of drusen of the optic disk].

The present abstract is about a case of drusen of the optic disc (DOD), consisting of three members, belonging to two generations: the mother (41 years) and two daughters (16 and 19 years). Their personal records showed nothing special, except case III-2 with crisis equivalent to the epileptic ones. No changes of the visual acuity and of the visual field were found. Ophthalmoscopy and angiofluorography showed: a bilateral and superficial location of the DOD; no vascular anomalies (discal and peridiscal) or other retinal changes; a trend towards flattening and getting more mat of the DOD, in older cases. It is debated upon the possibility that a single gene might be involved, responsible for an autosomal dominant or autosomal recessive transmission mode.

Adolescent↗

[Colobomatous pits of the optic nerve papilla associated with serous retinal detachment. The clinical and pathogenic aspects].

The present study is about a number of 19 cases (19 eyes), the patients having a congenital pit of the optic papilla (CPP) complicated with serous retinal detachment (SRD). The cases were selected, from a group of 41 patients with CPP. Average age of the cases was 37(31-54) years. The serous retinal detachment appeared under two different clinical appearances: the detachment of the internal retinal layers (DIRL) or retinal schisis, 10 cases, located between the papillae and macula, and involving the optic disc; the detachment of the external retinal layers (DERL), 9 cases, located within the macular area, without involvement of the optic disc. A number of 8 cases (42%) developed a macular hole, located within the external retinal layers. The cases with DIRL had better visual acuity, compared to those with DERL. This study proves the bilamellate character, of the serous retinal detachment. The disease starts with DIRL (retinal schisis), due to fluid passing at the level of the CPP and then DERL develops as a complication, following the degenerescence of the retinal layers within this area.

Adult↗

[Anterior ischemic optic neuropathy secondary to retrobulbar hematoma].

Two clinical cases are displayed, age over 70, with multiple vascular risk factors; following the retrobulbar injection performed for cataract surgery, retrobulbar hematoma and ischemic anterior neuropathy developed as complications. Pathogenesis of the optic ischemic anterior neuropathy may be explained by changes of a precarious hemodynamic balance and witch was previously settled, due to mechanic compression and increase of the intraocular pressure, which lead to the decrease of the blood pressure and implicitly to the development of optic neuropathy.

Aged↗

[Isolated obliteration of the cilioretinal artery].

Place on record the case patient of 51 years, who evince diminution visual acuity to the right eye, due to one precapillary occlusion of cilioretinal artery. Clinical syndrome to be characterized through diminution visual acuity, ophthalmoscopic (ischemic edema) and angio-fluorographic alters (the place of obliteration, ischemic zone, coterminous vessels alters, the absence of soft exudates). Etiopathogenic to be discussed the possibility one cholesterolemic ambole due to its localization and appearance ophthalmoscopic as well easily value of cholesterolemic. Functional prognostic was has been, due to localization obstruction of circulation preterminal, unique character of cilioretinal artery, as well anatomical specific features vascularity from the level of macula.

Ciliary Arteries↗

[Difficulties of diagnosis in a case of optic nerve drusen].

This paper presents a particullary case of optic nervue drusen. Ophthalmoscopic features (superficial drusen in one eye and deep drusen in another), clinical association with anisometropia and ambliopia, wrong interpretation of PEV and tomodensitometry mod to diagnostic confusion, supplementary investigations, prolonged and expensive treatment.

Child↗

[Cytomegalovirus retinitis and optic neuropathy in a case of an infectious HIV syndrome].

It is presented a case report of HIV syndrome complicated with cytomegalovirus retinitis and anterior ischemic optic neuropathy. It is reported a 36-years-old with type-B hemophilia and HIV-positive since few years. Despite treatment not recovered of ocular findings is obtained. Some literature data about ocular complications in HIV syndrome, particular features of CMV retinitis and anterior ischemic optic neuropathy etiopathogenesis are discussed.

AIDS-Related Opportunistic Infections↗

A fuzzy model for simulation and medical diagnosis.

The paper presents an original manner of treating a fuzzy model for simulation and medical diagnosis. The modelling is realized by means of an original fuzzy technique and general practioners reasoning, namely by fuzzy modelling the influence notion which features the symptoms and diseases influence over them and over the final diagnosis.

Artificial Intelligence↗