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M Morrow

Publications and source records attributed to M Morrow.

At least 73 records · Page 4Linked to original sources
PubMed1998

Breast-conserving surgery in the neoadjuvant setting.

The use of neoadjuvant chemotherapy for the treatment of patients with operable breast cancer remains controversial. Neoadjuvant chemotherapy is highly effective in achieving significant tumor regression. However, the primary goal of improved survival has yet to be clearly demonstrated. The largest prospective trial with adequate follow-up to report 5-year disease-free survival data demonstrated no significant difference between patients treated with neoadjuvant chemotherapy followed by locoregional treatment and locoregional treatment followed by adjuvant chemotherapy. Survival data from the National Surgical Adjuvant Breast and Bowel Project B-18 trial are not yet available. The potential impact on the breast conservation rate for patients with early operable breast cancer is small, and careful follow-up of the long-term risk of local recurrence for patients with neoadjuvant therapy induced downstaging followed by BCT is not yet available. At this time, neoadjuvant chemotherapy for the treatment of patients with operable breast cancer should be considered investigational.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1997

Results of hospital cancer registry surveys by the American College of Surgeons: outcomes of prostate cancer treatment by radical prostatectomy.

BACKGROUND: The number of prostate cancer patients treated by radical prostatectomy has increased. Different data sources have yielded various estimates of the outcomes of this treatment and the need for additional therapy. To provide additional perspective on these issues, the American College of Surgeons conducted surveys of cancer registries and reviewed related data. METHODS: In 1993, in the first phase of the study, hospital cancer registries and programs were sent survey forms and instructions requesting data on up to 5 patients treated by radical prostatectomy at their institutions in 1990. In 1996, in the second phase of the study, additional data were requested on treatment administered to the 1990 patients up to 5 years after surgery, and hospitals were also invited to submit new data on patients diagnosed in 1993. Responses were received from 482 hospitals concerning 2122 patients for 1990, and 265 hospitals provided data on 1304 patients diagnosed in 1993. Follow-up data on 1076 of the 1990 patients were provided by 258 hospitals. Kaplan-Meier survival curves were calculated to determine the probability of additional treatment after radical prostatectomy. RESULTS: Similar surgical pathology outcomes were reported for the 1990 and 1993 patients. For 1990 and 1993, respectively, it was reported that 27.5% and 29.7% of patients maintained erectile function adequate for intercourse after surgery. For 1990 and 1993, respectively, complete control or only occasional urinary incontinence requiring no pads was reported for 81.3% and 79.8% of patients. The surgical mortality rates were less than 1% for both the 1990 and the 1993 patients. The 5-year cumulative probability of any additional treatment after radical prostatectomy was 10.5%. Seminal vesicle involvement, positive surgical margins, lymph node involvement, capsular penetration, high Gleason score, and high prostate specific antigen were significantly associated with greater probability of additional treatment. CONCLUSIONS: Hospital cancer registries are valuable sources of data on patterns of care and outcome for prostate cancer patients. Continuing evaluation of the outcomes of prostate cancer treatments is needed to reconcile the differences in outcomes reported from different data sources.

Erectile Dysfunction↗
PubMed1997

Diet and the risk of salivary gland cancer.

Cancer of the major salivary glands is relatively rare, and little is known about its etiology. The only established risk factors are radiation exposure and a prior cancer. The role of diet in the development of salivary gland tumors has not been addressed previously. The results from a population-based case-control study conducted in the greater San Francisco-Monterey Bay area examining the association between dietary intake and salivary gland cancer risk are presented. Of 199 cases diagnosed with salivary gland tumors between 1989 and 1993, 150 (75%) were interviewed. Nine cases were subsequently excluded based on review of pathology specimens. Of 271 controls identified through random-digit dialing and the Health Care Finance Administration files, 191 (70%) were interviewed. Eight cases and seven controls who over- or underreported dietary intake were excluded from analysis. Vitamin C intake of > 200 mg/day compared with < or = 100 mg/day was associated with a 60% decrease in salivary gland cancer risk (odds ratio (OR) = 0.40, 95% confidence interval (CI) 0.22-0.70). Inverse associations observed for carotene, vitamin E, and fiber from fruits and vegetables were diminished when adjusted for vitamin C intake. Fiber from been sources was associated with a 51% decrease in risk after adjusting for vitamin C intake (OR = 0.49, 95% CI 0.26-0.92 for > 1.4 g/day compared with < or = 0.4 g/day). Cholesterol intake was associated with elevated risk (OR = 1.67, 95% CI 1.2-2.4 for a 10% increase in calories from cholesterol). These findings suggest that preventive strategies developed for common chronic diseases, such as increased consumption of fruits and vegetables and limiting foods high in cholesterol, also may be effective in preventing these rare tumors.

Adult↗
PubMed1997

Environmental factors and the risk of salivary gland cancer.

Cancer of the major salivary glands is rare, and little is known about its etiology. We conducted a population-based case-control study to elucidate the risk factors for these tumors. Of 199 cases diagnosed with salivary gland tumors between 1989 and 1993, 150 (75%) were interviewed. We subsequently excluded nine cases based on review of pathology specimens. We identified 271 controls through random-digit dialing and the Health Care Finance Administration files; 191 (70%) were interviewed. Therapeutic medical radiation treatment to the head or neck [odds ratio (OR) = 2.6; 95% confidence interval (CI) = 0.84-8.1], full mouth dental x-rays (OR = 1.6; 95% CI = 1.0-2.7), and ultraviolet light treatment to the head or neck (OR = 1.9; 95% CI = 0.89-4.3) were associated with increased risk. These elevations in risk were largely limited to those exposed before 1955, when the exposure dose was substantially higher. Occupational exposure to radiation/radioactive materials (OR = 2.4; 95% CI = 1.0-5.4) and nickel compounds/alloys (OR = 6.0; 95% CI = 1.6-22.0), as well as employment in the rubber industry (OR = 7.0; 95% CI = 0.80-60.3), increased risk. In men, current smoking (OR = 2.1; 95% CI = 0.98-4.7) and heavy alcohol consumption (OR = 2.5; 95% CI = 1.1-5.7) were associated with risk, but these factors were not strongly related to salivary gland cancer in women.

Adult↗
PubMed1997

Local Management of Primary Breast Cancer.

BACKGROUND: Various options are available for the local control of cancer in the breast -- mastectomy, conservation therapy, and mastectomy with reconstruction. METHODS: To evaluate the benefits and drawbacks of the available management options, the authors combine their extensive experience with a review of the literature on outcomes from these approaches. RESULTS: Conservation therapy provides survival outcomes similar to those from mastectomy. Differences in local recurrence rates can be minimized by close adherence to guidelines for patient selection, operative approach, and radiation technique. CONCLUSIONS: The role of the physician in selecting a local therapy for breast cancer has changed from one of informing the patient of the treatment to assessing the presence of medical contraindications to any of the treatments, educating the patients on each treatment approach, providing access to multidisciplinary consultation, and allowing the patient to choose an appropriate treatment approach.

Journal Article↗
PubMed1996

Breastfeeding in Vietnam: poverty, tradition, and economic transition.

Breastfeeding's crucial role in infant health is almost universally recognized. Although nearly all Vietnamese women initiate breastfeeding and duration is lengthy, infant growth faltering and malnutrition are widespread. Based on an analysis of in-depth interviews, observation in hospitals, and the available literature, the paper argues that complacency about breastfeeding in Vietnam is unwarranted. Discussion focuses on the principal influences on infant feeding in Vietnam, among them poverty, rapid socio-economic change, marketing by formula manufacturers, and some traditional perceptions about childbirth. The conclusion considers possible directions for breastfeeding promotion to address these multiple influences.

Breast Feeding↗
PubMed1995

Local control following breast-conserving surgery for invasive cancer: results of clinical trials.

Prospective, randomized clinical trials have demonstrated that the alternatives of mastectomy or conservative surgery plus radiation therapy provide equivalent survival for patients with invasive breast cancer. The identification of a subset of women who could undergo conservative surgery without radiotherapy would avoid the costs, inconvenience, and complications of radiotherapy and is an important research goal. Four randomized trials comparing conservative surgery alone with conservative surgery plus radiotherapy have demonstrated an average reduction in the risk of disease recurrence in the breast of 84% with the use of radiotherapy. No significant differences in survival have been observed, although the available studies lack sufficient numbers of patients to demonstrate a potential small, but clinically important, survival advantage for patients treated with radiotherapy. Subset analysis in the randomized trials and prospective studies of highly selected patients have failed to consistently identify a group of patients who do not benefit from radiation therapy. Any recurrence of breast cancer is psychologically devastating, and fewer than one half of the patients who have had disease recurrence after conservative surgery alone have undergone further breast-conserving treatment. At present, a group of patients who do not require radiotherapy has not been reproducibly identified, and radiotherapy should remain a part of breast-conserving therapy for invasive carcinoma.

Breast Neoplasms↗
PubMed1995

When can stereotactic core biopsy replace excisional biopsy?--A clinical perspective.

Stereotactic core biopsy is becoming increasingly popular as a technique which provides a histologic diagnosis for mammographic abnormalities while avoiding the trauma, deformity, and much of the cost associated with surgical biopsy. This review evaluates the published literature on the diagnostic accuracy of core biopsy for ductal carcinoma in situ and invasive breast cancer and the ability of core biopsy to characterize malignant lesions sufficiently to allow treatment planning. Issues of cost effectiveness are examined in the context of the degree of suspicion of the mammographic abnormality being sampled by core technique as well as subsequent breast cancer therapy.

Biopsy↗
PubMed1995

Effect of reexcision on the success of breast-conserving surgery.

BACKGROUND: The success of lumpectomy and radiotherapy is dependent on minimizing the residual tumor burden in the breast. Histologic margin status is one measure of the extent of residual tumor. This study was undertaken to determine the success rate of a single conservative lumpectomy in obtaining negative margins and to evaluate the incidence of residual tumor after biopsies with positive or unknown margins. METHODS: This is a retrospective study covering a 5-year period (June 1988-June 1993). RESULTS: Three hundred sixteen women had lumpectomies. In 239, lumpectomy was the initial operation after a positive fine-needle aspiration or as a diagnostic procedure. Thirteen cases had positive margins. Reexcision was performed in 90 cases. The indication for reexcision was a positive margin in 42 cases (4 with gross tumor) and unknown margin status in 48. Nineteen of the reexcisions for positive margins and 20 of the reexcisions for unknown margins contained residual tumor. Eighty-six (96%) of the 90 reexcised patients underwent breast preserving surgery. Patient age, menopausal status, histologic tumor type, tumor size, and clinical presentation were not predictive of residual tumor. CONCLUSIONS: The need for reexcision does not preclude breast preservation. Because single-stage lumpectomy is successful in achieving negative margins in 95% of patients, diagnostic biopsy without margin evaluation should be abandoned to avoid routine reexcision.

Adult↗
PubMed1995

Patient selection for breast conservation therapy with magnification mammography.

BACKGROUND: Breast-conserving therapy (BCT) is an appropriate treatment for women with breast carcinoma of limited extent. This study was undertaken to determine the ability of microfocal spot magnification mammography to identify women with multifocal or multicentric breast carcinoma who were unlikely to have all gross carcinoma removed with a limited breast resection. METHODS: Two hundred sixty-three women with mammographically visible ductal carcinoma in situ and stage 1 and 2 carcinoma who were clinical candidates for BCT were evaluated with magnification mammography before undergoing definitive local therapy. Biopsy specimens of additional abnormalities thought to have a greater than 2% risk of malignancy were obtained. RESULTS: Forty-seven women had other abnormalities in the index breast requiring intervention, and 216 had only the primary tumor identified. Mean age, cancer presentation, disease stage, and histologic tumor type did not differ between groups. BCT was successful in 97.2% of women without mammographic abnormalities versus 38% of women with abnormalities (p = 0.001). Clinical characteristics did not differ between patients undergoing successful BCT and those requiring mastectomy. Synchronous contralateral carcinoma was identified in 2.4% of women at risk. CONCLUSIONS: Magnification mammography allows accurate preoperative identification of patients requiring mastectomy or quadrantectomy and should be performed before diagnostic biopsy is done.

Adult↗
PubMed1995

Saving for hospital care costs in Singapore: are there lessons for Australia? [corrected].

Australian political leaders and policy analysts have increasingly sought to learn from Singapore, a nation which, despite its small size and lack of natural resources, has enjoyed rapid economic growth. Of particular interest to Australian policymakers has been Singapore's compulsory superannuation system, which has provided high levels of domestic savings and high levels of home ownership; it has also incorporated a scheme to enable Singaporeans to save for the costs of health care. In this article, Singapore's Medisave policy is described within its broader socioeconomic context. Saving for health care costs has been a largely neglected option in recent policy debate about reforming funding arrangements for hospital care in Australia. The potential for a formalised scheme for medical savings in Australia, subsidised by taxation concessions, is explored in terms of its socioeconomic policy implications, its congruence with Australian values, and the logistical ramifications of such a scheme.

Australia↗