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Biomedical subjects

M Morgan

Publications and source records attributed to M Morgan.

At least 415 records · Page 23Linked to original sources
PubMed1975

Etomidate, a new water-soluble non-barbiturate intravenous induction agent.

This paper describes clinical experimence, in 100 patients, with the new non-barbiturate, water soluble induction agent, etomidate. This drug produces sleep in one arm/brain circulation-time. There was no effect on pulse-rate, a slight fall in blood-pressure, and a low frequency of apnoea. Involuntary movements were noted, and in some patients these were severe. Etomidate warrants further evaluation as an intravenous induction agent.

Adolescent↗
PubMed1975

Influence of tetrahydro-aminacrine on muscle pains after suxamethonium.

The incidence and severity of muscle pains were investigated in patients who had been given suxamethonium and thiopentone anesthesia for bronchoscopy. Group I patients received no other drugs. Groups II and III received d-tubocurarine and THA respectively before suxamethonium. Administration of these drugs resulted in a highly significant reduction in the incidence of severe and moderate pains. The use of d-tubocurarine necessitated a significantly greater amount of suxamethonium to maintain paralysis.

Acridines↗
PubMed1975

Nerve endings in rat carotid body.

The carotid body of the rat consists of "glomera" interspersed by blood vessels and nerve bundles. Each "glomus" consists of 2-12 Type I cells, incompletely invested by 1-3 Type II cells. Type I cells are characterised by the presence of numerous dense cored vesicles in their cytoplasm and may exhibit "synaptic" -like contacts with each other. Small efferent nerve endings make synaptic contact with one or more Type I cells. Large cup-shaped afferent nerve endings make multiple synaptic contacts of two kinds with one or more Type I cells. A second kind of efferent nerve ending is occasionally seen in synaptic contact with one of these afferent nerve endings. A model for the mode of operation of the glomus as a chemoreceptor is proposed.

Animals↗
PubMed1975

Incentive motivation and behavioral inhibition in socially-isolated rats.

Rats reared from weaning in social isolation made more lever presses than controls on an alternating two-lever DRL schedule of reinforcement, and obtained fewer rewards. Isolates showed an increased tendency both to anticipate reward on the correct lever, and to perseverate on the lever which last gave reward, but their anticipatory deficit was relatively more marked. It is suggested that isolates act as if under an effectively higher level of food motivation. Measurement of home-cage food intake showed that the normal day-time depression of food intake was less marked in isolates than in socially-grouped animals.

Animals↗
PubMed1975

Methylated, blocked 5 termini in HeLa cell mRNA.

Poly(A)-containing HeLa cell mRNA prepared from cells labeled with [methyl-(3)H]methionine or [(32)P]phosphate was found to contain a variety of methylated, blocked 5'-terminal structures of two general types: m(7)GpppN(7)-Np and m(7)GpppN(m)-N(m)-Np. In addition, about one-third of the [(3)H]methyl label was present in the N(6)-methyladenosine; this labeled nucleoside was not found in the 3'-terminal one-third of the mRNA chain and thus may also be in the 5' portion of the mRNA.

Base Sequence↗
PubMed1975

Althesin as an induction agent for Caesarean section.

Thirty patients for elective lower segment Caesarean section were randomly divided into two groups. One group received 50 mulitre/kg of Althesin for induction of anaesthesia and the other, 100 mulitre/kg. The two maternal groups were similar. There was no significant difference in the clinical or biochemical status of the infants except that infants in the low dose group had a significantly higher PO2 in the umbilical venous and arterial blood.

Adult↗
PubMed1975

An investigation in man into the relative potency of lignocaine, bupivacaine and etidocaine.

The relative potency of lignocaine, bupivacaine and etidocaine was estimated by forearm skin weals in four volunteers. Potency was estimated as the time to half-recovery of a sharp sensation in response to a needle-prick. The increase in duration of action with increased concentration was greater for bupivacaine and etidocaine as compared with lignocaine. At the same concentrations, bupivacaine had a longer duration of action than etidocaine. However, etidocaine 1% had a longer duration of action than bupivacaine 0.5%.

Acetanilides↗
PubMed1975

The effect of extradural analgesia combined with light general anaesthesia and spontaneous ventilation on arterial blood-gases and physiological deadspace.

Arterial Po2 and Pco2 were measured at half-hourly intervals in eleven patients anaesthetized for lower limb vascular surgery with a combination of nitrous oxide 67% and halothane 0.3-0.5% in oxygen, and an extradural injection of bupivacaine. Values for the alveolar-arterial oxygen tension difference, physiological deadspace and deadspace-tidal volume ratio were calculated. Although both the alveolar-arterial oxygen tension difference and physiological deadspace were large, spontaneous ventilation was adequate to maintain both Po2 and Pco2 of arterial blood at acceptable values. Over the course of 2 hr following the extradural injection there were no significant changes in any measured value.

Adult↗
PubMed1975

Ethanol narcosis in mice: effects of L-dopa, its metabolites and other experimental variables.

Ethanol-induced narcosis was studied in mice as a function of pretreatment with L-dopa and its metabolites administered alone or in conjunction with Ro-4-4602, an inhibitor of aromatic-L-amino acid decarboxylase. These studies suggest that L-dopa prolongation of ETOH narcosis in mice may be due to formation of one or more toxic metabolites rather than to a direct involvement of dopamine. Ethanol narcosis also was studied in mice as a function of age of animals, concentration of ETOH, ambient temperature and saline pretreatment. Since manipulation of these variables produced alterations in ETOH narcosis, the need for their rigid control is indicated.

Age Factors↗
PubMed1975

Abdominal vagal paraganglia: distribution and comparison with carotid body, in the rat.

A study was made of the distribution of abdominal vagal paraganglia in the gastro-oesophageal region of 12 rats. In all rats 4-40 paraganglia were found embedded in, or closely associated with, the vagus nerves and their branches. The paraganglia consisted of groups of rounded, weakly chromaffin-positive cells surrounded by flattened cells and supplied by small nerves and blood vessels. The paraganglia were morphologically identical to simultaneously fixed carotid body tissue and showed similar fluorescence characteristics.

Animals↗
PubMed1975

Anaesthetic considerations in chronic renal failure.

This paper discusses the anaesthetic problems presented by patients in chronic renal failure. The anaesthetic agents and techniques used in 181 patients who underwent 941 operations (including 218 renal transplants) are described.

Acid-Base Equilibrium↗
PubMed1975

Failure of injected growth hormone to increase plasma glucose and insulin concentration in the puppy.

The resistance of puppies to the diabetogenic effect of administered growth hormone is well known. The possibility that this involves an adaptive increase in insulin secretion was explored by determining the effect of injected growth hormone on plasma insulin concentration at various age periods. Bovine growth hormone (1 mg/kg per day for 4 days) administered to 5-month-old puppies had no effect on plasma glucose or insulin levels nor on the effectiveness of injected insulin to lower plasma glucose levels. At 8 and 12 months of age the growth hormone regimen increased plasma glucose and insulin levels and produced a resistance to the hypoglycemic effect of injected insulin. It is evident that the difference between the puppy and adult in response to growth hormone is not due to excessive secretion of insulin by the puppy.

Age Factors↗
PubMed1975

Psychological improvement following arteriovenous malformation excision. Case report.

A patient with a right frontal lobe arteriovenous malformation demonstrated progressive intellectual deterioration on neuropsychological tests. Following complete excision of the arteriovenous malformation, the patient's visuomotor function and visual recall were greatly improved, probably the result of elimination of arteriovenous shunts that were taking blood away from functional tissue.

Frontal Lobe↗