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Biomedical subjects

M Moran

Publications and source records attributed to M Moran.

At least 127 records · Page 7Linked to original sources
PubMed1985

Cyclosporine in heart and heart-lung transplantation.

At Stanford University Medical Center from January 1968 until January 1984, 288 patients received 313 heart transplants. The immunosuppressive regimen before December 1980 consisted of azathioprine and prednisone, with or without rabbit antithymocyte globulin. After that time cyclosporine replaced azathioprine. In 92 recipients of 95 heart allografts, the 1- and 3-year survival rates were 82% and 65% to 70% respectively. In the 3 years from March 1981 to March 1984, successful heart-lung transplantation was accomplished in 13 of 19 recipients, using cyclosporine-based immunosuppression. Survival ranged from 1 to 38 months. While it is true that cyclosporine has improved survival in heart transplant recipients, has allowed successful heart-lung transplantation to be performed, has shortened intensive care unit and total hospital stays and therefore hospital costs, and has allowed easier management of rejection and infection, several disconcerting problems have not yet been resolved. These include hypertension that is difficult to control and renal dysfunction in all patients, and the fact that cellular and humoral rejection still occurs, as manifested by graft atherosclerosis, bronchiolitis obliterans and classic acute rejection. Better understanding and application of cyclosporine immunosuppression will undoubtedly minimize both cyclosporine- and non-cyclosporine-related postoperative complications and will improve survival even further.

Adult↗
PubMed1984

Oat cell carcinoma of the larynx and Eaton-Lambert syndrome.

Oat cell or undifferentiated small cell carcinoma is a rare malignant tumor of the larynx. Since this lesion was first described, only 23 cases have been reported in the literature. Oat cell carcinoma of the lung, however, accounts for 20% to 25% of all lung cancers and is frequently associated with a variety of paraneoplastic syndromes. A 64-year-old woman had a primary oat cell carcinoma of the supraglottic larynx associated with clinical and electromyographic evidence of the myasthenic syndrome of Eaton-Lambert. To our knowledge, this is the first description an oat cell carcinoma of the larynx associated with this syndrome, which supports the theory that oat cell cancers of the larynx and lung have a common histogenesis.

Carcinoma, Small Cell↗
PubMed1984

Vitreous changes after neodymium-YAG laser irradiation of the posterior lens capsule or mid-vitreous.

Exposure of four monkey and 26 rabbit eyes to neodymium-YAG laser irradiation to the posterior lens capsule or the mid-vitreous area clearly demonstrated significant vitreous changes (liquefaction) as measured by viscosity analyses and proton relaxation studies. We found marked molecular alterations in the vitreous of the exposed eye compared with the contralateral control (unirradiated) eye. These alterations, occurring immediately after laser treatment, were probably the result of acoustic transients accompanying the laser irradiation.

Aging↗
PubMed1984

Acceptance of sweet and salty tastes in 2-year-old children.

Taste acceptability, determined by volume of taste substances consumed during brief presentations, was assessed in 63 black 2-year-old children who had previously been tested at birth and at 6 months of age. Intake of sucrose solutions during taste tests was related to prior dietary exposure to sugar water. Children who had been regularly fed sugar water by their mothers consumed more sucrose solutions but not more water than did children whose mothers did not feed them sugar water. However, when these children were tested with sucrose in a fruit-flavored drink base, prior exposure to sugar water was unrelated to consumption of sweetened or unsweetened fruit-flavored drink. Thus, the apparent effects of dietary exposure on sucrose acceptability were specific to the medium in which sucrose was dissolved. Studies with sucrose solutions also revealed a significant correlation between sucrose acceptability determined at 6 months and at 2 years of age. Another series of tests evaluated response to salt with soup and carrots. Individual children who ingested more salty than plain soup also tended to ingest more salty compared with plain carrots. However, measures of salt consumption and salt usage obtained from mothers were unrelated to individual differences in acceptability of salty foods.

Beverages↗
PubMed1983

Papillon-Lefèvre syndrome. Report of a case treated with oral retinoid RO 10-9359.

We report a case of Papillon-Lefèvre syndrome in a patient aged 26 in whom the familial genetic study showed close consanguinity among the parents. Oral treatment with aromatic retinoid during 6 weeks provided nearly total healing of the cutaneous lesions. Among the explorations carried out, attention must be paid to the lessening of chemotactic factors in the blood serum. Throughout his life, the patient suffered pronounced bacterial infectious processes, the last being especially severe and leading rapidly to death.

Adult↗
PubMed1983

ECG findings in geriatric depressives given trazodone, placebo, or imipramine.

ECG effects were evaluated in 60 depressed geriatric patients in a drug-free baseline state and weekly during treatment with trazodone, placebo, or imipramine. Eighteen patients underwent crossover from placebo or imipramine to trazodone. Imipramine increased heart rate and was associated with more isolated ECG complications. Trazodone and placebo did not increase heart rate and had no other significant ECG effects.

Aged↗
PubMed1982

Sodium regulation: Sensory aspects.

A first step in reducing salt intake is to understand sensory control of ingestion. Salt and taste, the methodology for studying taste in human beings, the development of response to salt by infants and children, and dietary sodium and salt preference are discussed. The author's conclusion is that at present it is not possible to answer the question of why people consume as much salt as they do. More research is needed.

Animals↗
PubMed1978

Systems releasing action therapy with alcoholics: an experimental evaluation.

Described Systems Releasing Action Therapy (SRAT) and a controlled study that evaluated its effectiveness. The therapy combines physical and fantasy exercises and has its roots in the Bioenergetic and Gestalt traditions. To evaluate its effectiveness, 56 patients who were receiving treatment for alcoholism were assigned randomly to therapy and control groups. On 3-week follow-up, the therapy sample showed significantly more improvement than the controls on measures of blood pressure, physical symptoms, anxiety, hysteroid tendencies, disturbed feelings and self-image. Suggestive differences (interactions significant only at the .20 level) in favor of the therapy group also appeared on measures of vital capacity withdrawal, excessive drinking, anhedonia and four neurosis-oriented MMPI scales. However, 6-month follow-up data were relatively unimpressive. The results suggest this type of therapy is an effective one, at least for the short term.

Adult↗
PubMed1978

Adjuvant whole-lung radiation with or without adriamycin treatment in osteogenic sarcoma.

Eighteen consecutive patients with osteogenic sarcoma were treated after initial surgery with 2000 rads of whole-lung radiation for 21--28 days. Eleven of these patients went on to receive adriamycin (20 mg/m2 X 3 days every 6 weeks). Three of seven evaluable patients are free of disease in the radiation group (median time to recurrence, 130 days) while six of ten evaluable patients are free of disease in the radiation + adriamycin group (median time to recurrence, 310+ days). These results are similar to published experience with whole-lung radiation and adriamycin alone.

Adolescent↗
PubMed1975

Identification of a ribosomal protein essential for peptidyl transferase activity.

Extraction with 2 M lithium chloride removes a group of proteins (LiC1 SP) from 50S ribosomal subunits. Both the LiC1 SP and the resulting cores, which contain the remaining proteins as well as 5S and 23S RNA, lack peptidyl transferase activity, as measured by the "fragment reaction". Activity can be restored to the LiC1 cores by reconstitution with LiC1 SP under conditions of high temperature and high ionic strength. The LiC1 SP proteins were fractionated by carboxymethyl-cellulose and Sephadex G-100, and the individual fractions were tested by this reconstitution system. Of the 18 ribosomal proteins found in the LiC1 SP, only L16 is essential for reconstitution of peptidyl transferase activity.

Acyltransferases↗