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Biomedical subjects

M Moodley

Publications and source records attributed to M Moodley.

At least 37 records · Page 2Linked to original sources
PubMed1992

Rett syndrome in South Africa.

Rett syndrome is a fairly recently recognized neurodevelopmental disorder of unknown aetiology that affects exclusively girls in whom early development is apparently normal but by the age of 6-18 months autistic behaviour and dementia, apraxia of gait, stereotypic repetitive hand movements, seizures and deceleration of head growth occur. Except for one Brazilian case, all previous reported cases have been from the northern hemisphere. We report three children (two Indian and one African) with the clinical features of Rett syndrome and believe these to be the first documented cases in Indian and African children in the southern hemisphere. More widespread knowledge of this syndrome is required, especially in developing countries, in order to prevent unnecessary and costly investigations, and to help families deal effectively with this important syndrome.

Black People↗
PubMed1992

Prediction of acute renal failure following soft-tissue injury using the venous bicarbonate concentration.

Sixty-four patients with soft-tissue injuries were studied prospectively to determine whether an initial venous bicarbonate concentration (VBC) of less than 17 mmol/L would predict the development of myoglobin-induced acute renal failure. The VBC was > 17 mmol/L in 59 patients, seven of whom had myoglobinuria. All recovered without renal complications. The remaining five patients all had VBC < 17 mmol/L and four had myoglobinuria. Acute renal failure developed in four patients (p < 0.001). The VBC on hospital arrival was the most accurate predictor of these patients' risk for the development of acute renal failure following soft-tissue injury.

Acute Kidney Injury↗
PubMed1992

Foot deformities and occult spinal abnormalities in children: a review of 16 cases.

A retrospective clinical and radiologic study was made of 16 children with foot deformities and associated occult spinal abnormalities in a 3-year period. Eleven children had bilateral foot deformities; the deformities were unilateral in five. Midline cutaneous lesions of the back were noted in 13 children; the most common dermal sign was a hairy patch. All children had radiologic features of spinal dysraphism on combined computed tomography (CT) scan and myelogram. Spinal dysraphism was not considered in the initial assessment of four children. Children with foot deformity should therefore have a careful assessment of the spine, including a neurologic evaluation.

Child↗
PubMed1991

Rett syndrome.

Explore the source record for details and available documents.

Child, Preschool↗
PubMed1990

Mannitol in neonatal cerebral oedema.

Twenty-five full term severely asphyxiated newborn babies with cerebral oedema were divided into 2 groups and treated on a randomised basis with either Mannitol or no Mannitol. We report our findings and conclude that Mannitol is of no benefit in the management of cerebral oedema in severely asphyxiated term infants.

Apgar Score↗
PubMed1990

Chondrodystrophic myotonia (Schwartz-Jampel syndrome) in South African children.

Three children with the clinical features of the Schwartz-Jampel syndrome are presented, two with classical features and the third with physical and radiological features resembling those found in the Schwartz-Jampel syndrome but myotonia could not be elicited either clinically or electrophysiologically. Various arguments are put forward for the absence of myotonic phenomena in the latter child.

Black People↗
PubMed1990

The operculum syndrome: an unusual complication of tuberculous meningitis.

The operculum syndrome, not previously documented as a complication of tuberculous meningitis, is described in a three-year-old African boy. The appearance on CT scan correlates radiographically with anatomical descriptions of the operculum syndrome, and is useful in distinguishing the condition from pseudobulbar palsy.

Cerebral Cortex↗