The authors report the results of Dixon's assay modified by Follea in 24 cases of idiopathic thrombocytopenic purpura. The level of immunoglobulin G bound to platelet membrane was increased in 91 p. 100 of patients in the acute phase of the disease. An inverse correlation was demonstrated between platelet-bound antibody levels and platelet count as well as platelet survival. In all cases of refractory idiopathic thrombocytopenic purpura, the assay was positive and the mean level was higher. When the platelet count improved after prednisone therapy or after splenectomy, the level decreased. Platelet antibody determination seems to be useful for predicting the course of the disease. Patients with normal immunoglobulin G bound to platelet might have only C3, IgM or IgA. Dixon's assay is not specific to idiopathic thrombopenic purpura, since it is positive in other types of thrombocytopenia, but immunoglobulin G bound to platelet probably represents specific antiplatelet antibodies.

Blood Platelets↗

PubMedDate not supplied

[Extreme hypogammaglobulinemia disclosing large granular lymphocytes with hepatosplenorenal infiltration].

We report a case of large granular lymphocytosis, or chronic "natural killer" lymphocytosis, a newly described entity. We were able to demonstrate the proliferative character of the disease by the finding of karyotype abnormalities. This case was remarkable for the pre-existence, for at least three years, of severe hypogammaglobulinaemia, for the very slow course of the proliferative process and for the progressive and tumoral infiltration of the spleen and liver, then kidney.

Agammaglobulinemia↗

PubMedDate not supplied

[Cortical blindness in systemic lupus erythematosus].

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Aged↗

PubMedDate not supplied

[Cushing's disease successfully treated by transphenoidal hypophysectomy since eight years (author's transl) (proceedings)].

The authors show a case of true Cushing's disease by bilateral adrenal hyperplasia without pituitary tumor which is cured for eight years by only treated with transphenoidal hypophysectomy. They think that reaching by surgery, the nervous afferences from hypothalamus to hypophysis could play a part in ameliorating the pathologic relations which existed between two centers.

Adult↗

PubMedDate not supplied

[Inappropriate secretion of antidiuretic hormone: true and false Schwartz-Bartter syndrome. Apropos of 2 cases].

The authors report two cases and consider the various physiopathological mechanisms of inappropriate hypersecretion of antidiuretic hormone. An exploration including clearance of free water and, in some cases, estimation of ADH before and after a water load, then before and after administration of ethyl alcohol, permits one to determine the mechanism. It seems advisable to reserve the term Schwartz-Bartter syndrome to paraneoplasic syndromes linked to ectopic and autonomous secretion of ADH.

Adult↗