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Biomedical subjects

M Mongin

Publications and source records attributed to M Mongin.

At least 37 records · Page 2Linked to original sources
PubMed1987

New parameters in erythrocyte counting. Value of histograms.

In this report we rate a new, third-generation automated hematology system (Technicon Instruments H-1) that can furnish a full range of values, including erythrocyte parameters and a leukocyte differential count. Particular attention is focused on erythrocyte morphometric parameters, including measurement of cell size and hemoglobin content on a cell-by-cell basis. We assess the usefulness of new parameters derived from these measurements, such as mean corpuscular volume and red blood cell distribution width, which characterize cell size, and mean corpuscular hemoglobin concentration, and hemoglobin distribution width, which characterize cell hemoglobinization in evaluating normal and abnormal subjects. The value of these parameters in classifying anemias is assessed in our patient population that includes those with iron deficiency anemias and thalassemias, as well as other forms of anemia.

Anemia↗
PubMed1986

Increase in plasma concentration of plasminogen activator inhibitor, fibrinogen, von Willebrand factor, factor VIII:C and in erythrocyte sedimentation rate with age.

Elderly patients have previously been shown to have an increased plasma concentration of tissue plasminogen activator (t-PA) antigen (t-PA Ag). Since the concentration of t-PA Ag depends on both free t-PA and t-PA complexed with inhibitors, mainly plasminogen activator inhibitor (PA inhibitor), we have investigated the relationship between the plasma concentration of PA inhibitor and age in 20 elderly and 20 young individuals. Elderly individuals showed a slight increase in PA inhibitor, in parallel with increase on others, acute-phase proteins, fibrinogen, von Willebrand factor, factor VIII:C, and the erythrocyte sedimentation rate. The increase in PA inhibitor as well as other acute-phase proteins in the elderly may be significant in relation to the increased incidence of thrombotic disease.

Adult↗
PubMed1986

[Anemia and dysmyelopoiesis with marker chromosome and transferrin receptor anomaly].

A 64-year old man presented with microcytic hypochromic aplastic acquired anemia without iron depletion. His bone marrow was hypercellular with dyserythropoiesis and no stainable iron deposits. 59 Fe incorporation by erythroblasts was reduced, and the karyotype revealed an aneuploidy with marker chromosome. After study of transferrin receptor with specific antibody, we conclude that the receptor presents a functional defect.

Anemia, Hypochromic↗
PubMed1986

[Castelman's angiofollicular hyperplasia of multifocal form Apropos of 2 cases].

Castelman described as angiofollicular hyperplasia (AFH) a benign lymphovascular hyperplasia forming a single tumour, classically situated in the mediastinum. A multifocal lymph node form of AFH was individualised by Leibetseder and Turner about 10 years ago (MAFH). This is a rare syndrome, the clinical and biological characteristics of which are almost identical to angioimmunoblastic lymphadenopathy (AIL). The only difference is in the histology of the ganglia which shows changes of AFH. We report two cases of MAFH. In one patient with histological confirmation of splenic involvement the evolution was subacute. In the second case, the histological features of the lesions were observed to change during successive biopsies: appearances of AFH changed to typical AIL. This observation suggests that MAFH may be a disorder of the immune system. Usually considered as benign lymphatic hyperplasia with a chronic evolution, the long-term development of lymphoma poses the problem of the evolutionary potential of this condition, which may be likened to AIL in which lymphomatous transformation is also recognised.

Aged↗
PubMed1984

[Association of polymyositis, myasthenia, and thymoma. A case and review of the literature].

We report the case of a 51 years old woman with myositis, myasthenia gravis and thymoma. First apparent sign is myositis in 1976 but chest X ray show a mediastinal opacity and the patient reports an intermittent diplopia since 1973. The evolution of myositis occurs in two bouts in 1976 and 1981, Myasthenia gravis restricted to diplopia from 1973 to 1979 grow worse first alone then in association with increase of myositis signs in 1981. The mediastinal opacity seen on chest X ray in 1976 don't change and is revealed to be a thymoma at operation in 1981. After thymoma ablation myasthenic and myositis signs decrease. This pathologic association is found 24 times in literature and involves "giant cells" in muscle biopsy in about 50 p. 100 of cases and a myocarditis also with "giant cells". Those "giant cells" unusual in common myositis appears to have a prognostic value.

Adult↗
PubMed1984

[Plasma lactoferrin and the blood count of polynuclear neutrophils].

Plasmatic lactoferrin measure (LF) by immuno-enzymatic technique combined with neutrophil blood count (PN) on 100 subjects (controls and patients) allows us to show a LF increase proportional to circulating blood neutrophils. In neutropenia, plasmatic lactoferrin measure seems able to divide the central causes from the peripheric ones. Regarding the granulocytosis, LF levels are clearly higher in myeloproliferative diseases than in other causes. Lactoferrin could therefore represent an index of total circulating neutrophil pool but also seems to reflect the granulocyte activation.

Adult↗
PubMed1983

[Acquired hemophilia caused by antifactor VIIIc antibodies. Apropos of 3 cases].

In connection with three observations, we discuss clinical and biological characteristics of "acquired haemophilia". We insist on therapeutics problems: in all the cases corticosteroid and or immunosuppressive drugs are indicated: haemorrhagic accidents treatment depend on the clinical state severity and on the inhibitor concentration: indications of substitutive therapy, plasmapheresis and activated concentrate are considered.

Aged↗
PubMed1982

[Hairy-cell leukemia heralded by severe influenza. Apropos of 2 similar cases].

Two severe cases of virus A influenza with splenomegaly are reported. An underlying hematological disorder was suspected in both cases but the diagnosis could not be confirmed during the acute infectious episodes. The exact diagnosis was made two years later in the first case and seven years later in the second case. Both patients lead normal lives seven years later. The authors emphasise the similarity between the two cases with severe influenza at a very early stage of the disease when there were no changes in the blood count to explain the immune deficit.

Bone Marrow Examination↗
PubMed1981

[Glucagonoma without diabetes: a case report (author's transl)].

A further case of glucagonoma is reported, unusual features being the prolonged duration of cutaneous manifestations (12 years), and the absence of diabetes. Possible explanations for this anomaly: compensatory insulin or somatostatin secretion, production of a non functional glucagon, or low levels of circulating glucagon, are envisaged but without a formal response.

Adenoma, Islet Cell↗