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Biomedical subjects

M Moll

Publications and source records attributed to M Moll.

At least 37 records · Page 2Linked to original sources
PubMed1988

Metabolic and cutaneous events associated with hypoglycemia detected by sleep sentry.

Eighteen insulin-dependent diabetic subjects [age (mean +/- SD) 33.2 +/- 10.6 yr] participated in a study designed to determine the metabolic and cutaneous parameters associated with activation of the nocturnal hypoglycemia monitor Sleep Sentry. Plasma glucose, glucagon, epinephrine, norepinephrine, and pancreatic polypeptide concentrations were determined every 10 min during a 2-h constant intravenous insulin infusion (40 mU.kg-1.h-1). In addition, skin temperature and electrical conductance were monitored at the same time intervals, and subjects were asked to rate the degree to which they felt cold and/or sweaty. Ten of the subjects (alarmers) activated the device with a mean plasma glucose nadir of 52.8 +/- 13.8 mg/dl, whereas eight (nonalarmers) failed to do so despite a mean plasma glucose nadir of 50.5 +/- 8.2 mg/dl. There were no significant differences between alarmers and nonalarmers with respect to initial or nadir plasma glucose levels, rate of fall of plasma glucose, or changes in plasma epinephrine, norepinephrine, or pancreatic polypeptide concentrations. In addition, changes in skin temperature and conductance were similar in both groups as were descriptive variables including age, disease duration, gender, and level of glucose control. No subject reported an increase in coldness, whereas 80% of both groups reported an increase in sweatiness. Three subjects studied on more than one occasion over a year failed to exhibit consistent activation of the alarm. This study suggests that it may not be possible to identify patients for whom the Sleep Sentry would be a reliable addition to their self-management regimen and that physicians should exercise caution in recommending its use.

Adult↗
PubMed1987

New aspects of the kinetics of isoenzyme CK-MB during myocardial infarction: discontinuous release?

Intermittent liberation of the serum marker myoglobin is found in acute myocardial infarction, and the ST segment of the electrocardiogram also shows a phasic rise and fall. We therefore measured the serum marker CK-MB at close intervals of time and recorded an oscillation in the serum level. The peaks are not as high as in the serum myoglobin time curve, and it is not easy to decide if they represent the intermittent liberation of the serum marker. It was possible to distinguish between a "high release" and a "low release" group of patients: the former having a maximum CK-MB value of greater than 100 U/l and the latter of less than 100 U/l. Most patients showed 2-3 "initial peaks" within the first 8 h. The highest of these immediately preceded the climb to the definitive maximum value. We conclude that the small size of the peaks in the CK-MB time curve is due to a different mechanism of enzyme release.

Adult↗
PubMed1986

New perspectives on the function of coronary artery spasm in acute myocardial infarction: the thromboischemic reentry mechanism. A review of 10 years research on the pathophysiology of AMI.

Research during the last ten years into the pathophysiology of acute myocardial infarction (AMI) has made it gradually clearer that this is a phasic event. A number of independent authors have made this conclusion quite obvious. The authors of this review suggest that the alternating sequence of coronary spasm and dilatation should be described as the "thromboischemic reentry mechanism," which itself leads to waves of reperfusion, producing characteristic episodic changes in some of the parameters of AMI. The spasms are brought about by substances let loose from aggregating platelets. Metabolites released during the concomitant ischemia lead the vessel from spasm to dilatation. Following thrombolytic treatment, the 'staccato' signs of myoglobinemia disappear, because of the withdrawal of the spasmogenic products of the platelets. It could also be shown that the concentration of myoglobin in the serum as a result of the dilating effect of calcium antagonists is twice the mean maximum value that the myoglobin time curve would show without such treatment.

Animals↗
PubMed1981

[Characterization of cell wall constituents involved in the flocculation of Saccharomyces uvarum yeast strains].

Cell walls of flocculent strains (0006) and non flocculent strains (0019) of Saccharomyces uvarum (Carlsbergensis), grown in different media and taken in both growth and stationary phases, were treated with water and with 2 per cent (W/V) potassium hydroxide. This treatment yielded four fractions (FI, FII, FIII and FR). The fractions FI isolated from the flocculent cell walls contained more mannose and less protein than the corresponding fractions FI isolated from the non flocculent cell walls. The amino-acid composition was also different between the two types of fractions. A radioactive labelling technique revealed that the FI and the walls from flocculent cells bound on average two to three times as much 45Ca as did the FI and the walls from non flocculent yeast. The substitution of carboxyl groups in FI and walls with glycine methyl ester led to a great drop of the 45Ca binding capacity. This result suggests that carboxyl groups of the cell walls are involved in the flocculation process. But flocculation seems to be a phenomenon more complex than the simple formation of a Ca2+ bridge, the involvement of "lectin like" components easily removed from the cell walls, should not be rejected.

Amino Acids↗
PubMed1978

[Current knowledge on the organoleptic characteristics of beer].

This important subject will be considered in three parts: I. Tasting procedures. As there is no standard nomenclature in brewing for describing the organoleptic properties, each brewery has devised its own terminology for this purpose. Four organizations: the European Brewery Convention (EBC), the American Society of Brewing Chemists (ASBC), the Master Brewers Association of America (MBAA) and the Institute of Brewing have collaborated to produce a standard terminology for beer tasting suitable for international use. Different tasting procedures, as well as their statistical interpretation will be discussed. II. Threshold values of certain compounds. Several hundred compounds present in beer have been studied and their threshold values are known for certain types of beer. Particular methods of tasting have been tried out to determine precisely the threshold value of a pure compound in beer. III. Correlation between the tasting results and the physico-chemical properties of beer. The application of statistical methods of analysis to the testing results and physico-chemical properties of different beers has allowed the importance of certain constituants of these beers to be estimated.

Beer↗
PubMed1976

Transformation of the heterochromatin structure during epithelial cell differentiation in Microtus agrestis.

The interphase structure of the constitutive heterochromatin of the field vole, Microtus agrestis, was studied in the epithelium of the intestinal and respiratorial tracts, and was compared with the nuclear size and the proliferation rate of these tissues. For determining the nuclear structure and the mitotic and DNA labeling rate, Feulgen and HE-stained paraffin sections were used; measurements of the DNA content and of the nuclear and chromocenter areas were carried out on Feulgen-stained smear preparations of jejunal epithelial cells, nerve cells and glial cells with the integrating microdensitometer of Barr & Stroud and the image analyzer Microvideomat of Zeiss, respectively. In all epithelial tissues, a good correlation was found between the proliferating activity and structure of heterochromatin: the parts of the epithelia with a high amount of compact chromocenters in their nuclei also showed a high cell proliferation rate, whereas in differentiated, nondividing epithelial cells most of the nuclei were free of chromocenters. Between nuclei with and without chromocenters of the same tissues, size differences of about 75% were observed. The areas of chromocenters of diploid G1 nuclei of glial, nerve and jejunal epithelial cells were equal (3-4.8 micrometer2) although the total areas of the nuclei differed to an extent of up to 1,000%. The sum of the areas of two separate chromocenters was about 10% larger than the area of a fused chromocenter.

Animals↗