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M Modan

Publications and source records attributed to M Modan.

187 records · Page 11Linked to original sources
PubMedDate not supplied

The prevalence of diabetic retinopathy: effect of sex, age, duration of disease and mode of therapy.

Studying 445 diabetic patients, we investigated the effects of sex, age, duration of disease, and mode of diabetes therapy on the prevalence of diabetic retinopathy. Of the study participants, 193 were treated with insulin injections, 164 took oral antidiabetic medications, and 88 were managed on diet alone. The prevalence of diabetic retinopathy was highest among insulin-treated patients (64%), while in the oral medication and diet groups, it was 36% and 12%, respectively. Diabetic retinopathy was more prevalent among patients with prolonged duration of disease. Sex and age did not seem to affect the prevalence of diabetic retinopathy when adjustments were made for the duration of disease.

Administration, Oral↗
PubMedDate not supplied

Senile cataract and glucose intolerance: the Israel Study of glucose Intolerance Obesity and Hypertension (The Israel GOH Study).

Association of "senile" cataract (SC) with glucose intolerance (impaired tolerance and diabetes) was assessed by sex and age in a random population sample comprising 930 individuals aged 40-70 yr, who underwent concurrent oral glucose tolerance test and ophthalmoscopy. The eye examination was performed without knowledge of the glucose tolerance status. SC was defined as lens opacification preventing visualization of the eyeground or as surgical aphakia due to SC. To assess the independent effect of hyperglycemia, glycosylated hemoglobin (HbA1) was determined in 769 participants. In men, no association was found between SC, glucose intolerance, and HbA1. In women of all ages, glucose intolerance was associated with an SC risk ratio of 6.1 (95% confidence limits 3.3-11.1; P less than 0.001). Furthermore, SC was associated in women with increased HbA1 independently of the effect of glucose intolerance (P less than 0.01). These findings confirm the reported association of SC with diabetes (although unlike the Framingham and HANES population studies, the association was confined in women), indicate its presence at all degrees of glucose intolerance, and suggest a possible independent role of nonenzymatic glycosylation in its pathogenesis.

Adult↗
PubMedDate not supplied

The incidence of insulin-dependent diabetes mellitus in Israeli children and adolescents 0-20 years of age: a retrospective study, 1975-1980.

A survey of the entire population of Israel revealed 392 newly diagnosed type I diabetic children and adolescents aged 0-20 for the period of 1975-80. The mean annual age specific incidence of type I (insulin-dependent) diabetes mellitus was 3.8/10(5) for the age group 0-14 yr and 4.2/10(5) for the age group 0-20 yr. The incidence among the Jews of Ashkenazi origin was 6.8 X 10(5) and that for Jews of non-Ashkenazi origin was 4.3 X 10(5), whereas that for the Arabs was 1.2 X 10(5). The overall incidence is lower than that reported for similar populations in most European countries, the USA, Canada, and New Zealand; similar to that reported for Arabs in Kuwait; and higher than only that found in Japan. The relative importance of environmental and genetic factors in the interpopulation differences in incidence of type I diabetes remains to be established.

Adolescent↗
PubMedDate not supplied

ProMACE-CytaBOM: combination chemotherapy for diffuse large cell lymphoma.

ProMACE CytaBOM, a polychemotherapy regimen consisting of cyclophosphamide, doxorubicin, etoposide cytozar, bleomycin, vincristine, methotrexate and prednisone was administered on an outpatient basis to six consecutive patients with diffuse large cell lymphoma. All achieved a complete remission (CR). Two have relapsed. Actuarial analysis predicts 66.7% survival and 62.5% probability of remaining in remission at 40 months post diagnosis. The side effects of ProMACE CytoBOM were tolerable and included mainly vincristine induced peripheral neuropathy, infections and mucositis. Our results are consistent with the SWOG results, reported only recently, using the same combination chemotherapy regimen in patient with intermediate and high-grade non-Hodgkin's lymphomas. We conclude that ProMACE CytaBOM represents a highly effective and easy-to-administer regimen in patients with large cell lymphoma.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Scoring of vascular disease in the lower extremities.

Lack of standardisation in reporting the vascular status of patients leads to difficulties in comparing different series. A method of vascular scoring is presented, integrating symptoms, physical examination, vascular laboratory studies and arteriography. The score is expressed in a concise form by several letters and numbers supplying the relevant information as to the main segment involved, the severity of the ischaemia and the completeness of the examination. The files of 100 candidates for vascular surgery were recorded with the scoring method. Vascular indices were calculated by dividing the sum of points assigned to each item by the maximal available score. The internal consistency of the method was evaluated by computing separate indices for the three components of the scoring--clinical examination (CE), vascular laboratory (VL) and arteriography (AR)--and comparing them with the overall index and with each other. Correlation coefficients with the overall index were for CE 0.90, for VL 0.92 and for AR 0.75. The data on the 200 limbs were reviewed independently by three experienced vascular surgeons and ranked in order of increasing severity of ischaemia; the correlation coefficient between this ranking and one based solely on the scoring method was 0.91. A vascular scoring method may help create a mutual language among practitioners, enabling them to compare results and benefit from accumulating worldwide experience.

Adult↗