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Biomedical subjects

M Moalla

Publications and source records attributed to M Moalla.

At least 37 records · Page 2Linked to original sources

[Osteoarticular manifestations of sickle cell anemia. Update apropos of a series of 29 cases].

In a retrospective study, the authors report 14 cases of osteoarticular manifestations, among 29 patients affected with a sickle cell disease observed at adult age. They insist on their frequency and their interest for diagnosis and prognostic. Effectively, the diagnosis has been revealed on occasion of these manifestations in 9 cases/14. The articular signs are noted in 35%, and the osseous signs in 25% of cases.

Adolescent↗

[Mixed connective tissue disease (Sharp syndrome) with involvement of the trigeminal nerve and facial paralysis].

The authors report a case of mixed connective tissue disease with involvement of the fifth and seventh cranial nerves. While involvement of the trigeminal nerve is well-known, that of the seventh nerve is much less so. However, seventh nerve involvement is beginning to be recognized in other connective tissue diseases such as scleroderma. Neurological manifestations in Sharp syndrome are reviewed.

Adult↗

[Systemic lupus erythematosus, polymyositis and toxoplasma antibodies].

High toxoplasma antibody titers have been reported in polymyositis and other connectivitis with myositis. The authors describe a case of systemic lupus erythematosus with polymyositis and high titers of IgG toxoplasma antibodies. Studies of muscle biopsy specimens by immunofluorescence and inoculation of mice with muscle extracts failed to demonstrate the presence of Toxoplasma gondii. The nature of the toxoplasmic agression is discussed. It may be that reactivation of a previous infection due to the rupture of cysts was promoted by the immunologic disorders and complement deficiency related to systemic lupus erythematosus.

Adult↗

[Metacarpophalangeal calcifications in diffuse chondrocalcinosis. Radiologic study of ten cases (author's transl)].

The authors report ten cases of metacarpophalangeal calcifications in chondrocalcinosis. These calcifications are associated with a calcification of the triangular ligament of the wrist in the all cases. Cartilaginous calcifications of the wrist are found in 9 cases. Metacarpophalangeal calcifications concern mostly the third (9 cases) and the second (6 cases) metacarpophalangeal joint. They are present frequently on radial side (29 joints) rarely on cubital side (5 joints) with a calcification on radial and cubital side in 4 joints and a calcification on cubital side only in one joint. Calcic deposit concern almost the synovial and capsule, it is rarely cartilaginous one. The authors discuss the possibility of calcic deposit of the glenoidal fibrocartilage of the metacarpophalangeal joint.

Aged↗

[Glomerulosclerosis: myeloma or diabetes? (author's transl)].

A 52 year old man was admitted to hospital for persistent back pain, fixed proteinuria of 6g/24 h that lead to the nephrotic syndrome (proteids 40 g/l, albumin 21,2 g/l). Two possible etiologies were envisaged: 1) Myeloma with K light chains as evidenced by biological findings (absence of normal Ig, presence of K light chains both in blood and urine, malignant medullary plasmocytosis) as well as x-rays (small punched out lesions). 2. Diabetes mellitus (blood glucose 2,4 g/l) with retinal and neurological involvement. Percutaneous renal biopsy revealed nodular glomerular sclerosis compatible with both diabetes and myeloma as well as homogeneous refringent thickening of tubular basement membranes more specific of myloma. No amyloid deposits, myelomatous casts were seen and anti-K light chain fixation was negative at immunofluorescence. An evolution of 33 months duration let to chronic renal failure (plasma creatinine 47 mg/l). The respective role of myeloma and diabetes in the genesis of this glomerular nephropathy are discussed.

Biopsy↗

[CRST syndrome (Thibierge-Weissenbach's syndrome) and intra-articular calcification: a case report (author's transl)].

A case of Thibierge-Weissenbach's syndrome is reported in a woman with very advanced generalized scleroderma, telangiectases, subcutaneous calcinosis, and a Raynaud's syndrome. Atypical radiological appearances were noted: intra-articular calcinosis of the radioulnar, metacarpo-phalangeal, and metatarso-phalangeal joints. The published literature is reviewed.

Calcinosis↗

[Wegener's granulomatosis and pregnancy. A case].

Pregnancy concomitant with Wegener's granulomatosis is extremely rare: so far, only four cases have been published. The authors report a fifth case where the disease appeared during the post-partum period, a situation which has already been noted in two of the published cases. Interruption of a subsequent pregnancy was followed by a flare-up of the disease resulting in the patient's death. This suggests that post-partum and post-abortum are probably instrumental in the onset and deterioration of Wegener's granulomatosis. The two patients previously reported who received immunosuppressants combined with corticosteroids had no flare-up after delivery. It seems permissible to prescribe such a therapeutic combination before and after delivery or abortion, especially since the fear of foetal toxicity from these drugs seems to be exaggerated.

Abortion, Therapeutic↗

[Osteoarticular amyloidosis in hemodialyzed patients. Report of 4 cases].

Chronic hemodialysis is sometimes complicated by an osteoarticular amyloidosis, which happens after a middle delay of ten years, it can be expressed by a tunnel carpal syndrome, a shoulder pariarthritis, bony cysts, and erosive spondylarthropathy. The authors reported their experience about four cases, and insisted on some évocatoring radiologic aspects.

Adult↗