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Biomedical subjects

M Miyata

Publications and source records attributed to M Miyata.

At least 415 records · Page 23Linked to original sources
PubMed1991

Case report of amyloidosis-like glomerulopathy with hepatic involvement.

A few cases of nephrotic syndrome with the glomerular deposition of an amyloid-like material which did not stain with Congo red have been documented. But extrarenal deposits have not been previously reported in this disease. We describe here a case of nephrotic syndrome associated with the deposition of an amyloid-like material in the liver as well as in the renal glomeruli. The deposits were made up of fibrillar structures which resembled those of amyloid when viewed through the electron microscope but they did not stain with Congo red. This is the first report of amyloidosis-like glomerulopathy with extrarenal deposits.

Amyloid↗
PubMed1991

Automatic analysis of urethral electromyography for accurate diagnosis of voiding dysfunction.

An electromyogram contains much more information than observed in the gross pattern of an electromyogram simultaneously recorded with a cystometrogram. Being able to pick up some of the information would be helpful in the accurate diagnosis of ambiguous patients showing a discrepancy between clinical symptoms and laboratory data. This study analyzed electromyograms of the urethral and anal sphincter during the filling phase of the cystometrogram by means of automatic turns-amplitude analysis with a computer-assisted analyzer. In normal subjects, turns and amplitudes of an urethral electromyogram had increased frequency and size as the subjects felt a greater sensation of fullness. In patients with abnormal vesical function, the characteristics of the urethral electromyogram varied. Some of the patients with normal vesical activity and coordinated urethral sphincter, though their clinical symptoms strongly suggested neuropathic vesical dysfunction, showed a low frequency and low amplitude pattern of the urethral sphincter electromyogram. Anal sphincter electromyogram did not always show the same patterns as the urethral sphincter even in the normal subjects. The turns-amplitude analysis of urethral sphincter electromyogram will be of use for accurate diagnosis of vesical dysfunction.

Anal Canal↗
PubMed1991

[Continuous monitoring of penile rigidity and tumescence in Japanese without erectile dysfunction].

Continuous monitoring of penile rigidity and tumescence has been proved to be of use for accurate diagnosis of erectile impotence, since it provides objective recording of penile rigidity as well as circumferential expansion. Prior to clinical use of this procedure in Japan, a study was performed to clarify normal features of nocturnal penile tumescence of Japanese and to ensure safety of this procedure. The subjects consisted of 16 normal volunteers, aged from 24 to 44 years. With fully informed consent of the volunteers, nocturnal penile rigidity and circumferential expansion were simultaneously measured for three consecutive nights by means of RigiScan at the base of the penis (base) and at about five millimeters proximal to the coronary sulcus (tip). The minimum circumference of the penis was 62.7 +/- 4.6 mm (mean +/- SD) at the tip and 65.4 +/- 9.3 mm at the base. The maximum circumference, which meant full erection in the normal volunteers, was 102.5 +/- 14.2 mm at the tip and 108.6 +/- 14.7 mm at the base. The mean duration of tumescence, i.e. circumference expansion more than 10 mm, was 23.0 +/- 6.9 minutes at the tip and 38.3 +/- 12.0 minutes at the base. The mean rate of episodes of circumference expansion more than 10 mm was 0.75 +/- 0.27 per hour at the tip and 0.70 +/- 0.26 per hour at the base. The maximum rigidity lasting more than 10 minutes was 82.9 +/- 10.1% at the tip and 85.4 +/- 8.4% at the base.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

[A case of Menkes' kinky hair disease with a renal calculus and diverticula of the bladder].

Menkes' kinky hair disease is a poor prognostic congenital disease with X-linked recessive inheritance. This disease is clinically characterized by seizures, friable hair, growth failure, mental retardation and others. Recently it has been known that this disease is also characterized by multiple diverticula of the bladder and other urological abnormalities. A 6-year-old boy was diagnosed as having Menkes' kinky hair disease at another hospital several weeks after birth because of seizures, friable hair and low serum copper level. He voided by Credé's maneuver by the nurse because he could not void for himself. He was referred to our hospital for macrohematuria and micturition pain on October 8, 1989. Right renal staghorn calculus and multiple diverticula of the bladder were found by roentgenographic examination. He has been treated conservatively after discharge because of his poor condition.

Child↗
PubMed1991

Ultrasonographic monitoring of pancreatic pseudocyst during delivery.

A case of pancreatic pseudocyst complicating with pregnancy and delivery was reported. This primipara patient with pancreatic pseudocyst was able to achieve a full-term, transvaginal delivery of a mature baby. The usefulness of ultrasonic monitoring of the pseudocyst during labor was clinically demonstrated. When intra-abdominal pressure increased, pancreatic pseudocyst was deformed.

Adult↗
PubMed1991

Expression of immunoreactive E-cadherin adhesion molecules in human cancers.

E-cadherin (E-CD), a Ca(2+)-dependent adhesion molecule, plays a major role in the maintenance of intercellular junctions in normal epithelial cells in most organs. The expression of E-CD in human carcinoma samples (esophagus, stomach, and breast) was investigated using immunohistochemical staining, which was performed on surgical specimens using a monoclonal antibody for human E-CD. E-cadherin was strongly expressed in all normal epithelium examined. However E-CD expression in primary tumors of esophagus (11 of 15: 73%), stomach (5 of 20: 25%), and breast (9 of 20: 45%) was reduced, and 68% of these (esophagus: 8 of 11, stomach: 4 of 5, breast: 5 of 9) displayed heterogeneous E-CD expression. In some tumor cells with reduced E-CD expression, E-CD molecules were located in the cell cytoplasm. These results indicate that there are human cancer cells in which E-CD-related intercellular adhesion is impaired.

Adenocarcinoma↗
PubMed1991

[Diagnosis of penile erectile dysfunction: simultaneous recording of nocturnal penile rigidity and circumferential expansion].

This paper briefly reviews diagnostic examinations for penile erectile dysfunction and mainly refers to a newly developed ambulatory system of RigiScan which enables simultaneous recording of penile circumferential expansion and rigidity, introducing the latest values of variables of penile tumescence and rigidity in the Japanese without erectile dysfunction.

Adult↗
PubMed1991

[Changes of responses of gastrointestinal hormones after pancreatectomies].

In order to elucidate the changes of the gastrointestinal hormones (GIH), glucose and/or lipid were administered orally in 54 pancreatectomized patients, 22 gastrectomized patients and 28 healthy volunteers before and after the surgery. Peripheral plasma levels of cholecystokinin (CCK), neurotensin (NT), gastric inhibitory polypeptide (GIP) and pancreatic polypeptide (PP) were measured for 180 min by radioimmunoassay specific for each CIH. Hyperresponses of CCK, NT and GIP were observed before surgery in patients with tumor of the pancreatic head. The lack of bile in the alimentary tract was confirmed as one of causative factors for the hyperresponse of NT. No significant change was observed in response of CCK, NT, CIP and PP after caudal pancreatectomy. The responses of CCK and GIP were normalized after pancreatoduodenectomy (PD) or total pancreatectomy (TP). The response of PP was decreased after PD or TP. Such change of GIP was not noted after gastrectomy. These changes of GIH after pancreatectomies were considered to be caused by surgical removal of the structures in which these GIH mainly located.

Adult↗
PubMed1991

Prospective randomized study on the effect of ranitidine against injection ulcer after endoscopic injection sclerotherapy for esophageal varices.

Thirty-five consecutive patients undergoing endoscopic injection sclerotherapy for esophageal varices were randomly allocated to either ranitidine-administered group (18 patients) or ranitidine-nonadministered group (17 patients), in an attempt to evaluate the efficacy of ranitidine for prevention and healing of postinjection ulcer with a prospective randomized trial. Two of seventeen patients in the nonadministered group dropped out of this trial because of development of gastric ulcer, so 18 patients in the first group were evaluated and compared with the 15 remaining patients in the second group. Sclerotherapy was performed with 5% ethanolamine oleate and 0.6% polydocanol; the mean number of injection courses and the mean amount of sclerosant were the same in both groups. Moreover, there was no significant difference between the two groups in either the occurrence rate or the size of injection ulcer 1 wk after the last session. However, the persistence rate of ulcer 1 month after last injection in the ranitidine-administered group was significantly lower than that in the ranitidine-nonadministered group (6.3% vs. 38.5%, p less than 0.05). Our study demonstrated that ranitidine administration will help to hasten healing of postinjection ulcer, although it was not effective for prevention of injection ulcer.

Adult↗
PubMed1991

Application of renal microangiography to normal and diseased kidneys of cattle and mice.

Use of microangiography is now essential for the study of microcirculation in various organs. Renal microangiographic studies have been reported in rats, rabbits, dogs, human beings, and mice. However, we could not find any report on use of the technique in cattle, despite high incidence of renal disease in that species. The perfusion technique used in mice was improved over that of our previous report, and was applied to normal and diseased bovine kidneys. For the microangiographic technique, composition of the contrast medium, pressure of the injection, duration of perfusion, and washing of kidneys with heparinized saline solution before perfusion are important. In cattle, 1- to 2-mm-thick sections of the kidneys were generally necessary to observe renal vasculature: arcuate and interlobular arteries, afferent arterioles, and glomerular capillaries. In normal bovine kidneys, the angiographic and microangiographic findings were easily recognized as normal, compared with those of normal mice. In affected bovine kidneys, which histologically represented glomerulonephritis and pyelonephritis, angiography and microangiography revealed corresponding findings.

Angiography↗
PubMed1991

[Cyanide with vitamin B12 deficiency as the cause of experimental tobacco amblyopia].

The visual toxicity of tobacco smoke was studied and demyelination change of retrobulbar portion of the rat's optic nerve with an elongation of a peak latency time of visual evoked potentials (VEP) was demonstrated. Cyanide detoxication incapacity and deficiency of vitamin B12 (B12) have been considered as possible causes of tobacco amblyopia. In order to elucidate an influence of cyanide poisoning and B12 deficiency on the visual system, 12 male Wistar rats were subjected to 5 hour's daily inhalation of cyanide gas for 52 weeks, the concentration of which was adjusted to that of tobacco smoke. Six rats of these 12 were fed with a lacking B12 diet. Another 12 male Wistar rats were controls which did not undergo inhalation of cyanide gas, and half of them were fed a diet without B12. In 2 out of 6 rats with cyanide and inhalation and B12 deficiency, demyelination change could be recognized in the central portion of the retrobulbar optic nerve. The histological change was segmental and significant elongation of the peak latency time of VEP was not recognized. Cyanide gas inhalation at a low concentration was proved to be harmful to the optic nerve under the condition of B12 deficiency, but other toxic elements such as nicotine and carbon monoxide may be important factors to cause the more severe changes of the optic nerve with an abnormal VEP response recognized in the experimental tobacco amblyopia.

Amblyopia↗
PubMed1990

Endoscopic screening of early esophageal cancer with the Lugol dye method in patients with head and neck cancers.

The poor prognosis for esophageal cancer could be improved if lesions were detected at an early stage. To detect early esophageal cancer, endoscopic screening of the esophagus with the Lugol dye method was performed in patients with head and neck cancers who were asymptomatic but regarded as being at high risk for synchronous or metachronous esophageal cancer. Of 178 patients screened, 9 had esophageal cancer (5.1%). Eight of these patients (89%) were at early stages with no lymph node metastasis. Most of the lesions (9 of 13 lesions) were not detectable by barium studies or ordinary endoscopic study. The epidemiologic statistical analysis of the patients confirmed that they had a significantly high observed and expected number (O/E) ratio (39.7; P less than 0.001). These results demonstrate the value of endoscopic screening of the esophagus with the Lugol dye method in patients with head and neck cancers and imply that endoscopic screening with the Lugol dye method may be useful for detecting early esophageal cancer in individuals at risk for other causes.

Aged↗