Biomedical subjects
Publications and source records attributed to M Miyajima.
A rare case of a cystic cavernous angioma in a 20-year-old female was diagnosed preoperatively by magnetic resonance imaging and computed tomography. Total surgical removal resulted in a successful recovery. Cystic cavernous angioma is benign and can be completely-removed. The importance of magnetic resonance imaging in the differential diagnosis is emphasized.
A 66-year-old female suffering from HTLV-1 associated myelopathy (HAM) for more than 30 years was hospitalized because of memorial impairment, deafness, dysarthria, dysphagia, and complete paraplegia. She first noticed stiffness and weakness of the right leg at 35 years of age. Gait disturbance was slowly progressed and complete paraplegia developed 18 years later. Neurological examinations on admission revealed that she was bedridden with decubitus, mental deterioration (pre-dementia of subcortical type), bilateral optic nerve atrophy, severe sensory-neural deafness, dysarthria, complete paraplegia, and marked neurogenic bladder. Laboratory data showed mild normocytic anemia and moderate diabetes mellitus. Anti-HTLV-1 antibody titers in serum and CSF were 78,192X and 1,024X, respectively (PA method). Serum levels of soluble IL-2 receptor was markedly elevated (2,200 U/ml). Peripheral blood lymphocytes showed spontaneous proliferation when cultured for 5 days (3H-thymidine uptake; 45,285 cpm/5 X 10(4) cells). MRI examinations of the spinal cord disclosed a predominant atrophy of lower thoracic cord without any compressive lesions. Brain MRI showed diffuse high intensity lesions of the periventricular area on T2 weighted images. Such abnormalities were predominantly found in fronto-parietal region and were quite similar to those of leuko-ariosis. Single photon emission CT using 123I-iodoamphetamine showed hypoperfusion of cerebral white matter on delayed image. It has been reported that intellectual impairment and brain atrophy are not usually seen in HAM patients. The present case, however, shows that such abnormalities of the central nervous system could occur in HAM patients with a long duration of illness.
A 25-year-old female presented with a 1-month history of headache and vomiting. Computed tomography revealed several enhanced nodules with surrounding edema in the right cerebellum. A T2-weighted magnetic resonance image showed heterogeneous high signal intensity throughout the right cerebellar hemisphere. A tuberculin skin test was positive and the erythrocyte sedimentation rate was slightly high, but there was no other clinical evidence of a tuberculous process. The histological diagnosis of the surgical specimen was tuberculoma. The combination of surgery and antituberculosis chemotherapy eradicated the cerebellar lesions.
Bilateral breast tumors with a histologically scirrhous pattern were conclusively diagnosed as gastric carcinoma metastatic to the breast using mucosubstance histochemistry and electron microscopy. The majority of the carcinoma cells gave histochemically positive reactions for galactose oxidase-Schiff, stable class III con A, and high-iron diamine-alcian blue (HID-AB). Also electron microscopically, numerous HID-positive mucus droplets (sulfomucin) were seen in the carcinoma cells. These findings invalidated the possibility that the carcinomas were primary breast cancer. The practical applications of distinctive patterns of mucus secretion are discussed.
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Two inbred rabbit strains, JWY-NIBS and NWY-NIBS, were established by full-sib mating in the Nippon Institute for Biological Science, Laboratory Animal Research Station. The origin, breeding history, and biological characteristics of the two inbred strains are as follows. 1. JWY-NIBS: Origin: Japanese white rabbits which had been originally kept at a farm near mount Takao, then transferred to another farm in Fuchu and maintained as a closed colony for a long time. Date of the first full-sib mating: April, 1964. Date of the 20th full-sib mating: June, 1981. Age of maturity: 7-month-old in females, 7.5-month-old in males. Body weight at maturity: 2.8-3.0 kg in females, 2.8-2.9 kg in males. Marker genes: Hemopexin; HxS. Esterase; Est-1s. alpha-Protein; F type. 2. NWY-NIBS: Origin: A strain III of New zealand white rabbits imported from the Jakson Laboratory in USA. Date of the first full-sib mating: November, 1967. Date of the 20th full-sib mating: July, 1982. Age of maturity: 7.5-month-old in females, 8-month-old in males. Body weight at maturity: 2.8-3.0 kg in females, 2.9-3.1 kg in males. Marker genes: Hemopexin; HxF. Esterase; Est-1S. Est-2f. alpha-Protein; S type.
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