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Biomedical subjects

M Mitsunaga

Publications and source records attributed to M Mitsunaga.

At least 19 recordsLinked to original sources
PubMed1989

cw photon echo.

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Journal Article↗
PubMed1989

[A case report of Swyer-James syndrome].

A 43-year-old man with Swyer-James syndrome (SJS) was reported. The left side of his chest radiograph and computed tomogram was hyperlucent with decreased vascular markings. Pulmonary angiogram and scintigram showed markedly decreased blood flow of the left lung. Statistical study of the patients with SJS in Japan was done.

Adult↗
PubMed1988

[A clinicopathologic study of primary malignant lymphoma of the thyroid with a report of six cases].

From 1977 to 1984, 500 patients with thyroid disease (426 females and 74 males) were seen at the Kure Kyosai Hospital. Among them 6 patients (1 female and 5 males; all older than 50 y) were found to have a primary malignant lymphoma of the thyroid. Histologically, two were identified as being SNC, two were D-Mx, one was a D-L, and the last an IBL (plasmacytoid), according to the Working Formulation. Three patients manifesting a high grade malignancy died within 6 months after the diagnosis. Thyroid autoantibodies were detected in four patients, and, histologically, three of the four had chronic thyroiditis. The relationship between primary malignant lymphoma of the thyroid and chronic thyroiditis is discussed.

Aged↗
PubMed1987

Cytophilic anti-thyroglobulin antibody and antibody-dependent macrophage-mediated cytotoxicity in Hashimoto's thyroiditis.

Antibody-dependent macrophage-mediated cytotoxicity was studied to determine the significance of cytophilic anti-thyroglobulin antibody (ATgA) present in the sera of patients with Hashimoto's thyroiditis. Effector cells were normal human monocytes or guinea-pig peritoneal exudate cells, and target cells were human thyroglobulin(Tg)-coated chicken erythrocytes. Cytotoxicity was evaluated by morphological observation and by 51Cr-releasing assay. Normal human monocytes rapidly destroyed ATgA-bound Tg-coated chicken erythrocytes by extracellular cytolysis and by phagocytosis. On the contrary, human monocytes "armed" with cytophilic ATgA destroyed Tg-coated chicken erythrocytes slowly and to a lesser extent, and only by extracellular cytolysis. When normal monocytes or peritoneal exudate cells were incubated with Tg-coated chicken erythrocytes in the presence of the sera of patients with Hashimoto's thyroiditis, phagocytosis occurred rapidly, but extracellular cytolysis developed rather slowly. These data suggest the possibility that human monocytes participate in antibody-dependent cell-mediated cytotoxicity (ADCC) in vivo, which may be an important destructive mechanism in Hashimoto's thyroiditis. It is also possible that ATgA cytophilic for monocytes render non-immune peripheral monocytes cytotoxic against Tg-bearing cells.

Antibody-Dependent Cell Cytotoxicity↗