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Biomedical subjects

M Mitchell

Publications and source records attributed to M Mitchell.

At least 199 records · Page 11Linked to original sources
PubMed1983

Epidermolysis bullosa--pyloric atresia. An autosomal recessive syndrome.

A sister and brother each had epidermolysis bullosa and pyloric atresia at birth. Both died in early infancy of complications related to epidermolysis bullosa. Electron microscopic studies of skin biopsy specimens disclosed findings consistent with a diagnosis of epidermolysis bullosa letalis. The existence of epidermolysis bullosa-pyloric atresia syndrome as a distinct clinical entity with autosomal recessive inheritance is supported by the findings in these patients.

Epidermolysis Bullosa↗
PubMed1982

Visual attention in infants: a study of stimulus complexity, habituation, and sex differences.

A modification of Cohen's (1973) method was used to study responses to patterns of varying complexity in 4-mo.-old infants. Complexity in this context was defined in terms of the number of elements and the degree of internal contour contained in a given pattern. The infants were first presented with small red circles on two trials. This was followed by 16 trials of exposure to either 2 x 2 or 8 x 8 or 24 x 24 small red-circle matrix patterns which again were followed by two further exposures (trials) to the small red circle. Response decrement across trials was measured as a function of fixation, i.e., the duration of time the infant was judged to be looking at the stimulus, and latency, i.e., the time it took the infant to orient toward the stimulus pattern. Infants preferred the more complex patterns. All infants showed decrement in duration of fixation across trials for all three types of pattern. Latency of head turning did not change across trials but differed between pattern types. There were not significant sex differences in habituation rates as measured by duration of fixation and latency.

Attention↗
PubMed1980

Immunologic investigations of mucoid strains of Pseudomonas aeruginosa: comparison of susceptibility to opsonic antibody in mucoid and nonmucoid strains.

Mucoid strains of Pseudomonas aeruginosa, isolated from patients with cystic fibrosis, were studied for the prevalence of each of the seven Fisher immunotype antigens and were compared with their nonmucoid transformants, obtained by repeated subculturing, for susceptibility to opsonic antibody. Of the 30 strains tested--one from each of 30 patients--16 were typable and were tested in the opsonophagocytic assay with use of immunotype-specific rabbit antiserum; eight had significant opsonization by complement without antiserum. Of the eight strains requiring antiserum, seven strains required a higher minimum concentration of antiserum for a 1.0 log10 reduction of viable P. aeruginosa than the paired nonmucoid derivative. These end-point titers were significantly greater for nonmucoid Pseudomonas (P = 0.0007). A mucoid strain not requiring antibody for opsonization was shown to use primarily the alternative complement pathway. These results are consistent with the hypothesis that the immunodeterminant for opsonic antibody in nonmucoid strains is blocked in the mucoid strain.

Animals↗
PubMed1980

A G-band study of chromosomes in liveborn infants.

The results of a chromosome survey of 3993 liveborn infants, the majority of which have been studied using G-banding, are reported. The frequency of all types of chromosome abnormalities detected was similar to that found in previous newborn surveys, which were carried out on different socio-economic structure, but the incidence of aneuploid chromosome abnormalities was comparable in the two localities.

Aneuploidy↗
PubMed1980

[Synthesis and maturation of RNA after proliferative stimulation: comparison between fibroblasts and lymphocytes].

Comparison of the regulation of RNA metabolism following stimulation of mammalian fibroblasts in culture and of lymphocytes reveals that in both systems it is the processing and transport of gene transcripts which are the initial targets of the activation process rather than the gene transcription itself. In the case of the human lymphocyte, the time required for appearance of labeled RNA in cytoplasm after addition of labeled uridine diminishes progressively with duration of incubation with mitogen. Using adenine as a marker diminishes the latent period between addition of label and its appearance in cytoplasmic RNA. This may be due to polyadenylation of preexisting transcripts which are turned over at a high rate in the nucleus of resting cells but stabilized, processed and exported to the cytoplasm after stimulation.

Animals↗
PubMed1980

Disseminated canine histoplasmosis: a clinical survey of 24 cases in Texas.

The clinical features of 24 cases of disseminated canine histoplasmosis are presented. The enteric form predominated and the age at presentation was from five months to ten years. The principal clinical findings were chronic diarrhea, weight loss, pyrexia and anemia.A premortem diagnosis was reached in 20 cases, by demonstrating Histoplasma capsulatum organisms in peripheral blood smears, rectal scrapings or surgical biopsies. Five of seven dogs treated with amphotericin B were released in asymptomatic condition. Four of these cases relapsed six to 15 months following therapy. The overall mortality rate was 80%.

Amphotericin B↗
PubMed1979

Synovial sarcoma in a dog.

A 6.5-year-old, female Saint Bernard had a slowly growing tumor of the right tibiotarsal joint. Radiographically, bone surrounding the tumor was not involved. Subtotal surgical resection was undertaken. The tumor was classified histologically as a synovioma. Within 6 months, the tumor recurred locally and invaded the soft tissue proximal to the tibiotarsal joint. Eighteen months after initial examination, there was widespread right tibial invasion and pulmonary metastasis. The dog was euthanatized. The final histopathologic diagnosis was synovial sarcoma.

Animals↗
PubMed1979

Rhinoviruses: kinetics of ultraviolet inactivation and effects of UV and heat on immunogenicity.

The kinetics of ultraviolet inactivation for two human rhinoviruses and poliovirus were compared. No major differences in the rates of ultraviolet inactivation were detectable. All viral preparations inactivated by ultraviolet irradiation induced neutralizing antibody in guinea pigs. In contrast, when guinea pigs were immunized with a heat inactivated rhinovirus preparation, little or no neutralizing antibody was elicited. Immune electron microscopy of the heated rhinovirus preparations revealed the presence of particles resembling empty capsids. These results suggest that rhinoviruses and enteroviruses are affected in a similar manner when subjected to ultraviolet or heat inactivation.

Antibodies, Viral↗
PubMed1978

William Inge.

Explore the source record for details and available documents.

Drama↗