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Biomedical subjects

M Mirowski

Publications and source records attributed to M Mirowski.

108 records · Page 6Linked to original sources
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Considerations in the development of the automatic implantable defibrillator.

A highly reliable ventricular fibrillation detector and a satisfactory electrode system for delivering defibrillating pulses to the heart play a central role in the development of an automatic implantable defibrillator suitable for clinical use. Among the four implanted electrode designs tested, the combination of an electrode placed in the superior vena cava with a conformal electrode on the apex of the heart provided satisfactory defibrillation thresholds with ease of implantation. A new sensing method is also described for which an electrogram derived from the defibrillating electrodes is used as input. A form of a density function is developed for a filtered version of the input, ventricular fibrillation being characterized by a density curve lacking a large peak occurring at a level corresponding to the baseline of the filtered signal. These ideas are being incorporated into the design of a prototype implantable defibrillator delivering pulses of 24 joules.

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Coagulation and fibrinolysis in rats poisoned with mercuric chloride.

The effect of mercuric chloride on blood coagulation and fibrinolysis in rats was studied. The mercurial was administered to the animals intragastrically in a single dose of 17.9 mg Hg/kg and the effects were tested on the 1st, 3rd and 7th day. The symptoms of hypercoagulability accompanied by decreased fibrinolytic activity of the plasma were observed in the poisoned rats. The main reason of the lowered fibrinolytic activity seemed to be the inhibition of plasma plasminogen activator or the inhibition of plasminogen activation reaction catalyzed by this enzyme.

Animals↗
PubMedDate not supplied

Automatic implantable defibrillator for the patient with recurrent refractory malignant ventricular arrhythmias: case report.

Clinically, the first line of treatment for patients experiencing potentially lethal arrhythmias includes antiarrhythmic medications and/or treatment of underlying causes such as ischemia or congestive heart failure. However, if the treatment is not successful in controlling the arrhythmia, the automatic implantable defibrillator is a viable alternative for the prevention of sudden death in these patients. The case report presents one example of how the automatic implantable defibrillator can supplement conventional medical therapy when success in suppressing recurrent arrhythmias cannot be obtained. This concept has been demonstrated in this 59-year-old woman who underwent several medication trials in an attempt to control her life-threatening arrhythmias.

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