Biomedical subjects
Publications and source records attributed to M Mimoun.
The supracondylar process in an osseous spur located above the medial condyle of the humerus. It may be responsible for compression of the median, as well as the ulnar, nerves. Diagnostic must be directed in this direction whenever a deficit is found in the nerve distribution territory of one of these nerves.
Although very rare, fractures of the lesser multiangular (trapezoid) bone may be suspected clinically and demonstrated radiographically by special projections.
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The authors report a case of traumatic rupture of the tendon of the adductor magnus. It was operated on one month after the injury when it had formed a painful contractile tumour in the perineal region. The tendon was re-attached to the femur. The result was satisfactory. The authors have made a review of the literature.
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In fractures of the lower end of the radius, the presence of a posteromedial fragment should be recognized if present. This fragment with two articular surfaces, if not reduced, will damage the radiocarpal and inferior radioulnar articulations. The diagnosis needs to be made on 3/4 X-ray views, as the fracture is often mistaken for a Colles' fracture. The author advises reduction and fixation by a method of double pinning. By comparing two sets of statistics, the overall results are shown to be improved without more complications.
Few studies have referred to the implication of apoptotic processes following hormonal treatment. No data are available on the effects of progesterone in breast cells. In order to gain insights on the effects of the gonadal steroids and antiestrogens in breast cells, we have carried out studies on apoptosis in different breast materials. We have developed a model of normal breast cells in cultures that remain hormone-dependent. On these cells and in some hormone-dependent breast cancer cell lines (T-47-D, ZR75-1, MCF-7) we have observed an antiapoptotic effect of estradiol (E(2)) and a potent proapoptotic effect of some antiestrogens. Progestins were also proapoptotic in normal as well as in hormone-dependent breast cancer cells. In order to understand the mechanisms of these hormones on apoptosis, we studied the bcl-2 family proteins. We demonstrated that E(2) increased the antiapoptotic proteins, bcl-2 and bclx(L), whereas, the progestins drastically decreased bcl-2 expression and weakly bclx(L) levels. We investigated the mechanisms by which E(2) increased bcl-2 expression. Our results using quantitative RT-PCR showed that E(2) increased bcl-2 mRNA levels at 48 h of treatment via a transcriptional mechanism. None of the hormone treatments altered the proapoptotic protein levels, bax and bak. We also studied the in vivo expression of bcl-2 and other members of its family in biopsies of normal breast tissues according to the menstrual cycle. Bcl-2 displayed a strong cyclical variation and seemed to be the most hormone-dependent member of the family.
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The skin covering role of the nutrient flap is only accessory. However, this role is essential for an ordinary flap. In stage IV arteriosclerosis of the lower limbs when classical revascularization techniques cannot be performed, the nutrient flap can be spread over the distal extremity of the limbs. It provides a supplementary blood flow to ischaemic zones and it induces the neoformation of a vascular network. The nutrient flap avoids the need for high amputation and preserves weight bearing by maintaining the heel. Four clinical cases are detailed and the surgical techniques are described. The flap usually raised from latissimus dorsi, is anastomosed to the popliteal artery by means of an inverted saphenous vein graft, and is spread over the extremity of the limb after a wide excision of all the necrotic tissues.
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