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M Milner

Publications and source records attributed to M Milner.

60 records · Page 4Linked to original sources
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Changes in leucocyte sodium transport in normotensive relatives of hypertensive subjects. Dissociation from blood pressure.

It has been postulated that depressed membrane sodium transport is a necessary step in blood pressure elevation in essential hypertension. Accordingly, leucocyte sodium efflux-rate constants were estimated in 14 normotensive subjects who had one or more first-degree relatives with essential hypertension, and also in 14 matched control subjects with no such family history, before and after taking bendrofluazide for 7 days. Efflux rates in the controls did not change after the diuretic. However, in the relatives, mean total sodium efflux-rate constant was at first significantly depressed but later rose to normal with the diuretic. This was due almost entirely to an increase in glycoside-sensitive sodium pump activity. Blood pressure remained unchanged in both groups. Thus, assuming that perturbations in leucocytes reflect similar abnormalities in other cell lines, major changes in sodium transport in the normotensive individual without accompanying changes in blood pressure suggest that, while these changes may be a marker for later hypertension, they do not participate directly in blood pressure control.

Adult↗
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Suboptimal compliance with periconceptual folic acid in an Irish hospital population.

Awareness of and compliance with periconceptual folate was measured by questionnaire in our antenatal and infertility populations. Awareness was somewhat better in the private antenatal and infertility patients, but compliance was universally very poor. A substantial proportion of pregnancies were planned, and therefore there is potential for a much higher level of compliance.

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