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M Miller

Publications and source records attributed to M Miller.

At least 937 records · Page 52Linked to original sources
PubMed1972

Hydroxyproline heterooligosaccharides in Chlamydomonas.

Most of the hydroxyproline in Chlamydomonas reinhardtii is glycosidically linked to oligosaccharides and a monosaccharide that are different from the arabinosides found in hydroxyproline-containing plant cell walls previously examined. Of particular interest is the presence of hydroxyproline-O-galactose. These differences may be common to the volvocalean green algae and may be related to lower tensile strength of the cell walls of this group of plants.

Arabinose↗
PubMed1972

Segmental aneuploidy and the genetic gross structure of the Drosophila genome.

By combining elements of two Y-autosome translocations with displaced autosomal breakpoints, it is possible to produce zygotes heterozygous for a deficiency for the region between the breakpoints, and also, as a complementary product, zygotes carrying a duplication for precisely the same region. A set of Y-autosome translocations with appropriately positioned breakpoints, therefore, can in principle be used to generate a non-overlapping set of deficiencies and duplications for the entire autosomal complement.-Using this method, we have succeeded in examining segmental aneuploids for 85% of chromosomes 2 and 3 in order to assess the effects of aneuploidy and to determine the number and location of dosage-sensitive loci in the Drosophila genome (Figure 5). Combining our data with previously reported results on the synthesis of Drosophila aneuploids (see Lindsley and Grell 1968), the following generalities emerge.-1. The X chromosome contains no triplo-lethal loci, few or no haplo-lethal loci, at least seven Minute loci, one hyperploid-sensitive locus, and one locus that is both triplo-abnormal and haplo-abnormal. 2. Chromosome 2 contains no triplo-lethal loci, few or no haplo-lethal loci, at least 17 Minute loci, and at least four other haplo-abnormal loci. 3. Chromosome 3 contains one triplo-lethal locus that is also haplo-lethal, few or no other haplo-lethal loci, at least 16 Minute loci, and at least six other haplo-abnormal loci. 4. Chromosome 4 contains no triplo-lethal loci, no haplo-lethal loci, one Minute locus, and no other haplo-abnormal loci.-Thus, the Drosophila genome contains 57 loci, aneuploidy for which leads to a recognizable effect on the organism: one of these is triplo-lethal and haplo-lethal, one is triplo-abnormal and haplo-abnormal, one is hyperploid-sensitive, ten are haplo-abnormal, 41 are Minutes, and three are either haplo-lethals or Minutes. Because of the paucity of aneuploid-lethal loci, it may be concluded that the deleterious effects of aneuploidy are mostly the consequence of the additive effects of genes that are slightly sensitive to abnormal dosage. Moreover, except for the single triplo-lethal locus, the effects of hyperploidy are much less pronounced than those of the corresponding hypoploidy.

Aneuploidy↗
PubMed1972

Experimental papillary necrosis of the kidney. II. Electron microscopic and histochemical studies.

Renal papillary necrosis was induced in rats by bromoethylamine hydrobromide and studied electron microscopically and histochemically. Morphologic changes appear to develop in vessels and tubules simultaneously, rather than tubular lesions preceding and leading to vascular lesions, or vice versa. Abnormalities are recognized as early as 3 hours, but platelets do not make their appearance until 12 hours, eliminating primary vascular thrombosis as the source of papillary injury.

Adenosine Triphosphatases↗
PubMed1972

Dyschondroplasia.

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Angiomatosis↗