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Biomedical subjects

M Mignon

Publications and source records attributed to M Mignon.

316 records · Page 18Linked to original sources
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[Clinical and secretory results of the highly selective vagotomy. Study of sixty cases (author's transl)].

The clinical and secretory status of sixty patients nine-fourty-four months after highly selective vagotomy for duodenal ulcer is exposed. Mortality and morbidity are very low. The long-term clinical results are Visick I and II in more than 85 p. cent of cases. The results of basal and peak acid output after insulin and pentagastrin are presented. The question: "is highly selective vagotomy sufficient for hypersecretors?" is discussed.

Adult↗
PubMedDate not supplied

[Dietary behavior and nutritional status of patients with ileorectal anastomosis after total colectomy for hemorrhagic rectocolitis].

In ulcerative colitis, total colectomy with ileo-rectal anastomosis is commonly performed in Europe. Whether this procedure induces a protein caloric malnutrition and/or a radical modification of diet is not known. Twenty-one patients with ileo-rectal anastomosis and 21 normal subjects who were matched for age, sex, social behavior and habitat were therefore studied concomitantly. In all subjects, the diet contents in energy, nitrogen, glucids, lipids, proteins, dietary fibers and vitamin C, were quantitatively determined. Evaluation of nutritional status included body weight measurement and determination of biological markers: serum albumin, prealbumin, transferrin, hemoglobin and urinary creatinine. The energy and nitrogen intakes of the patients were not different from those of control subjects: respectively 2,187 +/- 612 versus 2,038 +/- 589 kcal/day and 15.4 +/- 5.9 versus 16.0 +/- 5.2 g/day. In contrast, the dietary fiber and vitamin C contents of the diet were significantly lower in patients than in control subjects: respectively 9.7 +/- 5.5 versus 14.6 +/- 5.6 g/day and 43.5 +/- 29.9 versus 72.4 +/- 23.7 mg/day (p less than 0.05). There was no difference in nutritional status between patients and the control group. Thus, in ulcerative colitis, ileorectal anastomosis seems to cause neither protein caloric malnutrition nor radical modifications in diet. Nevertheless, the low intake in vitamin C suggests that supplementation with ascorbic acid may be useful in these patients.

Adult↗
PubMedDate not supplied

In vitro assessment of antacid efficacy using a computer-controlled 'artificial stomach-duodenum' model reproducing gastroduodenal flux regulation.

We have developed an artificial stomach-duodenum model made up of three compartments representing the stomach, (including a fragment of hog gastric mucosa), the proximal duodenum, and the distal duodenum. Gastroduodenal flow rates are controlled by a microcomputer capable of (1) adjusting gastric emptying and alkaline secretion in the proximal duodenum according to intragastric pH; (2) adjusting pancreatic alkaline secretion according to proximal duodenum pH; and (3) simulating acid response to food ingestion. Antacid drugs were added 90 min after simulated food ingestion in near-physiological or duodenal ulcer conditions. Aluminum phosphate-containing antacids resulted in a persistent antacid effect, due to their adsorption to the gastric mucosa; this prolonged the buffering capacity at pH 2.4 to 120 min. Aluminum+magnesium hydroxides and calcium+magnesium carbonate combinations mainly exerted neutralizing activity, inducing an increase in the gastric emptying rate. In the duodenal ulcer simulation, the pH of the gastric contents was lower and the antacid effect was shorter than in the 'physiological' simulation.

Aluminum↗
PubMedDate not supplied

Is gastrinoma a medical disease?

Zollinger-Ellison syndrome (ZES) is a rare disease. Its management concerns symptoms related to the gastric acid overproduction that characterizes the syndrome and to the gastrin-producing tumor(s) usually located in the duodenal wall and/or the endocrine pancreas. Acid hypersecretion is now controlled by the use of powerful antisecretory agents. Management of the malignant process(es) has become the primary goal of modern strategy: it aims first at curing the disease and second at prolonging patient survival by prevention of hepatic metastasis. In patients with the sporadic form of the disease and without liver metastases, it is currently possible to localize and to surgically remove the endocrine tumor(s). This progress has been made feasible by refinements in modern medical imaging. At present, however, disease cure, even in the most favorable conditions, is not be greater than 30 to 50 percent at five years. In patients with ZES integrated in the context of multiple endocrine neoplasia type I, disease cure rate is extremely low, although occasional patient survival can be as good or even better than in the sporadic group. Disseminated malignancy (liver and/or extra-abdominal lymph nodes or bone localization) remains the principal determinant of early death. Surgical treatment is usually precluded in such cases. Liver transplantation has not been successful in these patients.

Endoscopy↗