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Biomedical subjects

M Michal

Publications and source records attributed to M Michal.

At least 163 records · Page 9Linked to original sources
PubMed1996

[Chondroid lipoma].

Chondroid lipoma had not been defined until 1993. Here presented case was a 30-year old woman with a well limited soft tissue tumour of the left thigh. In histology, the encapsulated tumour consisted of mature adipocytes in common lipoma like areas and of a chondroid component in which lipoblastic or hibernoma like cells were surrounded by a myxohyaline matrix. Both components were connected and mutually transient. Tumour cells showed S-100 protein and laminin positivity in immunohistochemistry. Cells of the chondroid component had distinct ultrastructural features of adipose and cartilagineous differentiation. Chondroid lipoma is a benign tumour which is to be distinguished from extraskeletal myxoid chondrosarcoma and myxoid liposarcoma.

Adult↗
PubMed1995

Desmoplastic cellular blue nevi.

We describe five cases of cellular blue nevus (CBN) accompanied by an abundant desmoplastic reaction. The cells within the desmoplastic regions reacted strongly immunohistochemically with antibodies to S-100 protein and HMB-45 and were negative to antibodies to smooth muscle actin and desmin, providing evidence that the abundant collagen deposits were the product of the nevus cells. The microscopic picture of desmoplastic CBN can differ considerably from that of common CBN, and differential diagnosis is discussed.

Actins↗
PubMed1995

Patterns of cell proliferation in actinic keratoacanthomas and squamous cell carcinomas of the skin. Immunohistochemical study using the MIB 1 antibody in formalin-fixed paraffin sections.

We report the pattern of cell proliferation in 20 cases of actinic keratoacanthomas and 20 cases of squamous cell carcinomas of the skin as shown by a new monoclonal antibody, MIB 1, raised against the recombinant Ki-67 antigen. The substantial differences between proliferation patterns in these two entities emphasize the different nature of these two entities.

Antibodies, Monoclonal↗
PubMed1995

Shadow cell differentiation in tumours of the colon and uterus.

We report on six patients with tumours of visceral organs (three patients with endometrial adenocarcinoma with squamous cell differentiation, one patient with atypical hyperplasia of endometrium, and two patients with adenocarcinoma of the colon with squamous cell differentiation), where unquestionable differentiation into shadow cells was observed. In all six cases the shadow cells were found mostly in the morules of immature squamous cells. The shadow cells were morphologically identical, on the light microscopical and ultrastructural level, to similar cells found in pilomatricomas. They were often accompanied by granulomatous giant cell reaction and calcification.

Adenocarcinoma↗
PubMed1995

Ultrastructure of composite tumours consisting of giant cell fibroblastoma and dermatofibrosarcoma protuberans.

We present here ultrastructural findings in three composite tumours having giant cell fibroblastoma--dermatofibrosarcoma protuberans components occurring in adult patients. We further hypothesize that these 3 tumours belong to the group of neoplasms that can show giant cell fibroblastoma, dermatofibrosarcoma protuberans, dendritic pigment cell, myxoid, and fibrosarcomatous differentiation. We consider the giant cell fibroblastoma areas of the tumours to represent a well-differentiated component of these neoplasms.

Adult↗
PubMed1994

Plexiform xanthomatous tumor. A report of three cases.

We describe three cases of plexiform xanthomatous tumor in middle-aged men. The tumors shared some morphological features with xanthoma, cholesterotic fibrous histiocytoma, and plexiform fibrohistiocytic tumor. However, no hyperlipoproteinemia was found in our cases, and many morphological features distinguish the plexiform xanthomatous tumor from all the other entities.

Actins↗
PubMed1994

Giant-cell fibroblastoma with pigmented dermatofibrosarcoma protuberans component.

A unique case of giant-cell fibroblastoma that contained a pigmented dermatofibrosarcoma component (Bednár tumor) is described. The melanin pigmented dendritic cells found in the dermatofibrosarcoma component were round or spindle-shaped and had bipolar extensions. They were S-100 protein positive. Our case indicates the close histogenetic relationship between giant-cell fibroblastoma and dermatofibrosarcoma protuberans. The occurrence of the pigmented melanin-laden dendritic cells in our tumor further substantiates the theory that Bednár tumor is a pigmented variant of dermatofibrosarcoma protuberans.

Adult↗
PubMed1994

Nodular transformation of splenic red pulp due to carcinomatous infiltration. A diagnostic pitfall.

Autopsy of three women dying of disseminated carcinoma of stomach, colon, and breast, respectively, revealed a grossly unremarkable spleen. Microscopic examination demonstrated a nodular transformation of the red pulp, simulating a follicular lymphoma. Immunostaining revealed dissociated carcinomatous cells between the nodules, and this was thought to be the cause of the nodular transformation.

Aged↗
PubMed1994

Epidermoid carcinoma arising in Warthin's tumour: a case study.

We present a case of epidermoid carcinoma arising in Warthin's tumour of parotid gland in an 80-year-old woman. Light microscopy revealed small foci typical of benign Warthin's tumour with transition to epidermoid carcinoma. Immunohistochemical and ultrastructural observations confirmed the epidermoid features of the malignant cells. The differential diagnosis of a metastasis from an epidermoid carcinoma to the stroma of Warthin's tumour and also of the so-called metaplastic variant of Warthin's tumour is discussed.

Adenolymphoma↗
PubMed1994

Mucinous naevocellular naevi.

We report 4 cases of a naevocellular naevus variant containing abundant amounts of mucinous matrix. The mucinous matrix was Alcian blue (pH 2.5) and Halle's colloidal iron positive and mucicarmine and PAS negative. When the blocks of tumours were cut down, regions typical of common intradermal naevi were found in all 4 cases. The differential diagnosis with mucinous carcinoma of the skin and myxoid malignant melanoma is discussed.

Adenocarcinoma, Mucinous↗
PubMed1994

[Atypical decubital fibroplasia (ischemic fasciitis)--a new pseudosarcomatous entity].

Two cases of atypical decubital fibroplasia (ischemic fasciitis) were presented. Both patients were immunocompromized and their lesions were located in usual decubital places (back shoulder, femorogluteal region). Histology was typical: 1. zone of fibrinoid necrosis, 2. neighbouring cellular parts reminding of proliferative fasciitis. Focal high cellularity with atypical ganglioid fibroblasts and mitotic activity imitated sarcoma. Immunohistochemistry showed expression of vimentin in all cells and of KP1 (CD 68), lysozym as well as F-XIIIa in majority of them. There was not any expression of desmin, actin, S-100 protein, cytokeratin and epithelial membrane antigen. Importance of atypical decubital fibroplasia (ischemic fasciitis) is in its histological similarity to sarcoma-as it was in both the presented cases.

Adult↗