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Biomedical subjects

M Meurer

Publications and source records attributed to M Meurer.

At least 163 records · Page 9Linked to original sources
PubMed1983

[Immune complexes in dermatology today. A critical inventory].

The kinetics and various localizations of immune complex deposits in the skin are briefly described with special reference to clinical and experimental immune complex dermatoses. The complexes can localize in various areas of the skin of dermatoses and of experimentally induced lesions. The difference between transient and persistent immune complex dermatoses might provide an immune clue for the study of the kinetics and the biologic activity of immune complexes in the skin. Future research will focus on the detection of antigen, the enhanced elimination of immune complexes from skin or other organs and the regulation of inflammatory reactions.

Animals↗
PubMed1983

[Hereditary angioneurotic edema. Clinical syndrome and therapy].

Hereditary angioneurotic edema is transmitted as an autosomal dominant disease. It is characterized by a deficiency of the C1 esterase inhibitor. Clinical manifestations are periodic swelling of the extremities, face, upper airways and abdominal viscera. We described one patient to demonstrate the clinical features and current treatment. Danazol therapy is discussed.

Adult↗
PubMed1982

[Eosinophilic fasciitis (Shulman syndrome)].

Scleroderma like skin indurations without internal organ involvement, joint contractures, eosinophilia, and inflammatory infiltration of the fascia between subcutis and muscle are considered as characteristic features of eosinophilic fasciitis (EF). We report a further case of a 30 years old diabetic confirming to the syndrome defined by Shulman 1974. Corticosteroid therapy resulted in remission of disease symptoms, however a rebiopsy revealed no effect of therapy on histopathologic changes. A critical review of 118 cases in the literature is presented to explore the relationship of EF to scleroderma.

Adrenal Cortex Hormones↗
PubMed1982

[FTA-ABS test].

Explore the source record for details and available documents.

Fluorescent Antibody Technique↗
PubMed1982

[Serum immunoglobulins in scabies].

Infections with Sarcoptes scabiei induced changes of serum immunoglobulin concentrations in 25 of 35 patients (71%). According to the persistence of the symptoms in this disease, the patients were divided into two groups (shorter or longer than 3 weeks). In the initial phase elevated IgE levels were found in 14 of 15 patients. Increased IgE concentrations were demonstrated only in six of 20 patients of the second group. IgA, IgG, and IgM did not reveal significant alterations in the serum concentrations of either group.

Adolescent↗
PubMed1982

[Treatment of emergency situations in autoimmune diseases with plasma exchange].

Plasma exchange has been applied successfully to treat severely ill patients with autoimmune diseases in recent years. We report on 12 patients with systemic lupus erythematosus (SLE), myasthenia gravis (MG), and Goodpasturés syndrome (GS), that have been treated with membrane plasma separation. Two to three liters of plasma were exchanged per session. Three to nine treatments were done within 1--4 weeks. Human albumin solution was used for replacement of the discarded plasma. Improvement was seen in 3 out of 5 SLE patients, in all 5 myasthenic patients and in one of the two patients with GS. Plasma exchange in combination with immunosuppressive therapy is indicated in states of active autoimmune diseases, not controllable by routine immunosuppression. For long-term treatment, however, immunosuppressive medication should be used.

Adolescent↗
PubMed1980

[The spectrum of antinuclear and anticytoplasmatic antibodies in collagenoses].

This article gives a review of antinuclear and anticytoplasmatic antibodies and their profile and antigen specificity in systemic rheumatic disease. Available methods for the detection of these autoantibodies are summarized and their diagnostic and prognostic value for autoimmune disorders discussed.

Abnormalities, Multiple↗
PubMed1979

Comparison of three immunoassays for immune complexes in rheumatoid arthritis.

Three widely used radioassays that depend on different principles for the measurement of circulating immune complexes (CIC) in biologic fluids are the monoclonal rheumatoid factor (mRF), Raji cell, and C1q binding tests. A comparison of the ability of these methods to measure immune complex-like material in 71 sera and 30 synovial fluids of 91 patients with rheumatoid arthritis (RA) was carried out by a group working in adjacent laboratories in a single institution. The highest number of abnormal levels in the seropositive group was detected by the C1q binding assay (91%). Levels of CIC by the mRF and Raji cell tests were elevated in 81% and 76% of the patients, respectively. The closest correlation was between the Raji and mRF tests (r = 0.44 and P = 0.002) although one depends on complement fixation and one does not. Though significant correlations between the levels of CIC determined by the C1q test and either the mRF (P = 0.2) or Raji cell (P = 0.3) assay were not found in this group, 59% of the samples had elevated levels by all three tests. The frequency of CIC in the sera of patients with seronegative RA was much lower, with the C1q test again giving the highest number of abnormal results (29% versus 16% and 12% for the Raji and mRF tests). In view of the technical problems associated with these tests, particularly lack of a uniform reliable standard, it is likely that all three tests measure the same material in most RA sera and that some of the differences observed are related to inherent variability in the tests themselves rather than intrinsic differences among the CIC detected in these samples.

Adult↗
PubMed1978

Circulating immune complexes in active Behçet's disease.

Levels of immune complexes (IC) were determined by the Raji-cell and C1q-binding radioimmunoassays in the sera of eighteen patients with Behçet's disease. Eight patients (44%) were found to have significantly elevated levels of IC (range 56 to 1600 microgram equivalent aliquots of heat aggregated IgG (AHG/ml) by the former test and nine by the latter (7 to 500 microgram equivalent AHG/ml). The presence of IC showed a significant correlation with disease activity score (P = 0.003, Mann-Whitney Rank Sum Test). Abnormal values of IC tended to remain abnormal when sera were retested after 1 year. There was no correlation between IC and duration of disease or any specific organ involvement. The IC were found predominantly in fractions of about 19S and greater when fractionated by sucrose density gradient or Sephadex column techniques. The results suggest the possibility that IC may contribute to the pathophysiology of Behçet's disease.

Adult↗
PubMed1977

Oral pemphigus vulgaris. A report of ten cases.

The conditions of ten patients were diagnosed as pemphigus vulgaris limited to the oral cavity. In eight patients the histopathologic findings were consistent with oral pemphigus. Direct immunofluorescence demonstrated intercellular substance (ICS) deposition of C3 either alone or in combination with IgG, IgA, IgM, C4, C1q, properdin, and factor B in all nine patients tested. Circulating ICS antibodies were detected initially in eight of the ten patients, nine of whom had positive titers at a later date, without subsequent development of cutaneous lesions. Physicians should be alerted to a diagnosis of pemphigus in patients who have chronic erosive disease confined to the oral cavity. Prompt diagnosis by means of routine histopathologic and immunofluorescence studies followed by early initiation of treatment are warranted.

Adult↗
PubMed1977

[Skin necroses following the use of a 2-per-cent Pyoctanin solution].

The case of a child is reported in whom a circumscribed necrotic skin reaction developed in the gluteal fold after application of 2% crystal violet (Pyoktanin) in aqueous solution. Similar cases are described after topical treatment with 1% solutions of dyes. For direct application to intertriginous areas, triphenylmethane dyes should be used in lower concentrations.

Buttocks↗