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Biomedical subjects

M Meier

Publications and source records attributed to M Meier.

At least 127 records · Page 7Linked to original sources
PubMed1979

Automatic recognition of squirrel monkey vocalisations by means of a filterbank.

Up to now the problem of classifying squirrel monkey vocalizations has not been solved satisfactorily. The problems is now approached by a method, which consists of 2 phases. At first the monkey vocalizations are compared with the aid of physical criteria and classified by types. According to the classification of types, the membership of the individual vocalizations is tested.

Animals↗
PubMed1978

Developing interdisciplinary courses for allied health students: a retrospective view.

Innovative interdisciplinary education in allied health has been developed in order to give students insight into role competencies of other professionals, improve the quality of health care while reducing costs, and facilitate the interdependent functioning of allied health care providers in meeting patient or client needs. The process of interdisciplinary course development requires the same communication and needs identification by faculty as is necessary for the provision of team care by practitioners. A retrospective account of interdisciplinary course development in a major health sciences center, together with materials developed for class presentation, may serve to encourage this type of activity elsewhere.

Allied Health Personnel↗
PubMed1977

Importance of cardiac and vascular beta-receptors in the action of phentolamine.

To determine to what extent the effects of phentolamine (PHE) are mediated by the cardiac and vascular beta-receptors, the action of the drug was studied in anaesthetized cats pretreated with beta-blockers. Blockade of the cardiac beta-receptors with either propranolol or metoprolol entirely prevented the increases in heart rate, dP/dt and cardiac output caused by PHE. In animals pretreated with propranolol (in a dose blocking the vascular beta-receptors) or metoprolol (in a purely cardio-selective dose) PHE significantly lowered blood pressure to the same extent as in untreated controls. The effects of PHE on the heart are thus conditional on the integrity of cardiac beta-receptors, whereas it seems improbable that vascular beta-receptors have any part in its vasodilative action. Evidence presented in the literature rather suggests a predominantly central mode of action.

Animals↗
PubMed1977

Isolation and characterisation of a low molecular weight inhibitor (of chymotrypsin and human granulocytic elastase and cathepsin G) from leeches.

Two protein proteinase inhibitors were isolated and purified from the leech Hirudo medicinalis by means of gel filtration and ion-exchange chromatography. They inhibit chymotrypsin, subtilisin and the granulocytic neutral proteases elastase and cathepsin G. They proved to be homogeneous in polyacrylamide and dodecylsulfate gel electrophoresis and by end group analysis; only threonine was found as N-terminal amino acid residue using the dansylation technique. These inhibitors, which we call eglins, are stable in neutral and weakly acid (pH 3) solutions and resist non-specific proteolysis. From the amino acid compositions, a molecular weight of 6 600 - 6 800 is calculated for both inhibitory proteins, which is in good agreement with a value of about 6000 estimated by dodecylsulfate electrophoresis. The eglins contain an unusually large amount of hydrophobic amino acid residues but no methionine, isoleucine or--a rarity--cysteine residues or disulfide bridges. To our knowledge, the eglins are the first examples of proteinase inhibitors of the protein type which are not stabilized by disulfide bridges.

Amino Acids↗