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Biomedical subjects

M McKibbin

Publications and source records attributed to M McKibbin.

30 records · Page 2Linked to original sources
PubMed1999

The effect of once-daily latanoprost on intraocular pressure and pulsatile ocular blood flow in normal tension glaucoma.

PURPOSE: To determine the effect of once-daily 0.005% latanoprost on intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) in patients with normal tension glaucoma (NTG). METHODS: The diurnal IOP and sitting POBF were determined for 32 eyes of 19 NTG patients after a washout period. The subjects were treated with 0.005% latanoprost for 3-4 weeks and the measurements repeated. Statistical analysis was performed using the Wilcoxon signed rank test. RESULTS: Median IOP before and after treatment were 19 and 15 mmHg respectively (p < 0.001). The IOP reduction correlated with the initial IOP before treatment (p < 0.01) and was accompanied by an increase in median POBF from 656 to 796 microliters/min (p < 0.001). CONCLUSIONS: Once-daily treatment with 0.005% latanoprost provides a significant and stable IOP reduction in the majority of NTG patients after short-term treatment. This is accompanied by a significant increase in POBF.

Administration, Topical↗
PubMed1999

Incidence of corneal melting in association with systemic disease in the Yorkshire Region, 1995-7.

AIMS: To estimate the incidence of corneal melting or necrotising keratitis in association with systemic disease in the Yorkshire Region and to determine the type and duration of the systemic association. METHODS: In a prospective study, vigorous attempts were made to identify all patients presenting with newly diagnosed corneal melting over a 3 year period. RESULTS: 27 patients were identified during the study period. Rheumatoid arthritis and Wegener's granulomatosis were the most common disease associations. Corneal melting was a late complication of rheumatoid arthritis, but usually occurred during early and overt systemic disease in patients with Wegener's granulomatosis. CONCLUSION: The annual incidence of corneal melting in the Yorkshire Region is 3.01/million/year (95% CI = 0.7-9.6).

Adult↗
PubMed1999

Management of ocular perforations resulting from peribulbar anaesthesia.

PURPOSE: To analyze the clinical presentation and outcome of treatment for globe perforation secondary to peri-bulbar anaesthesia. METHODS: Eight patients (3 females and 5 males) aged 66-84 years were included in the study. Ocular perforations were suspected in 3 cases before or during surgery, in 4 cases diagnosis was established within one week and in one case at 3 weeks. Three patients underwent indirect argon laser photocoagulation to seal the retinal break, one patient had cryotherapy, 3 patients underwent a pars plana vitrectomy with fluid gas exchange and endo-laser; and one patient refused any further treatment. RESULTS: The final visual acuity after a mean follow up of 14 months was better than 6/9 in 2 patients, between 6/9-6/12 in 4 patients, and perception of light in 2 patients. CONCLUSION: If diagnosed early and treated adequately, a majority of patients with globe perforation during periocular anaesthetic could be saved.

Aged↗
PubMed1997

The value of pre-operative investigations in local anaesthetic ophthalmic surgery.

This study was performed to assess the value of routine investigations performed on ophthalmic patients undergoing local anaesthetic surgery. Patients attending the pre-operative assessment had investigations ordered as outlined in accordance with the guidelines of the Joint Working Party on Anaesthesia in Ophthalmic Surgery. The results of investigations were sealed in a clearly marked envelope and stapled to a prominent position on the notes. Any envelopes found unopened at the end of surgery were assumed to have been unseen by either the anaesthetist or surgeon. The effects on patient management were noted. Abnormal results were found in 102 of 314 investigations performed in 100 patients. Of the 100 envelopes 95 were unopened at the end of surgery. No patients had their peri-operative management changed because of the investigations performed. An adequate pre-operative assessment with a history and examination is sufficient in most patients undergoing local anaesthetic ophthalmic surgery, avoiding unnecessary investigations.

Aged↗
PubMed1996

Assisted conception and retinopathy of prematurity.

This study was performed to assess the workload imposed by treatment for infertility on a retinopathy of prematurity (ROP) screening programme. We reviewed the records of all babies born between August 1991 and December 1994 as a result of treatment in the Assisted Conception Unit of this hospital, and of all babies screened for ROP over the same period. Of the babies born after assisted conception treatment, 20% fulfilled the ROP screening criteria. ROP of any stage was present in 23% of all the assisted conception babies screened. This group also accounted for a large proportion of those reaching stage 3 disease and of those requiring treatment.

England↗
PubMed1996

The pre-operative assessment and investigation of ophthalmic patients.

This study was performed to document the prevalence of pre-existing medical disease amongst 105 patients awaiting ophthalmic surgery, and to assess the usefulness of investigations performed in accordance with the guidelines of the Joint Working Party on Anaesthesia in Ophthalmic Surgery. Patients attending the preoperative assessment clinic prior to ophthalmic surgery all had a full medical history taken and a clinical examination performed. Investigations were then ordered in accordance with the guidelines of the Joint Working Party on Anaesthesia in Ophthalmic Surgery. Pre-existing disease was present in 74 patients and abnormal results were obtained from 77 of the 318 investigations. Only 132 of the investigations were felt to be clinically indicated, and of the 77 abnormal results only 11 were unexpected. Despite the high prevalence of medical disease, patients awaiting ophthalmic surgery should be investigated only when clinically indicated and not on the basis of age or sex alone.

Adult↗
PubMedDate not supplied

Inherited retinal telangiectasia with glial proliferation.

We describe five patients from a family of Pakistani origin with inherited retinal telangiectasia and glial proliferation. Characteristics of this condition include: variable visual loss; peripapillary retinal telangiectasia with vascular incompetence on fluorescein angiography; glial proliferation; cystoid macular edema or altered macular pigment; retinal hemorrhage; and abnormal electroretinopathy. We discuss the similarities with and distinguishing features from other documented conditions and the mode of inheritance.

Adult↗