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Biomedical subjects

M McGrath

Publications and source records attributed to M McGrath.

86 records · Page 5Linked to original sources
PubMed1978

High-performance liquid chromatographic determination of plasma and urinary 1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3,7-dicarboxylic acid.

A high-performance liquid chromatographic method for the analysis of 1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3,7-dicarboxylic acid (I) in plasma and urine is described. A statistical evaluation of the assay technique has shown acceptable accuracy and precision at concentrations as high as 2.0 microgram/ml of plasma or 29.0 microgram/ml of urine for samples augmented with 1. As little as 0.08 microgram/ml of I in plasma or 0.42 microgram/ml of I in urine were quantitatively determined. The mean relative error for the assay of unknown concentrations of I in plasma and urine was +/- 8% and +/- 3%, respectively. This method was used for the analysis of I in the plasma and urine of rhesus monkeys following oral administration of 200 mg/kg of nalidixic acid.

Animals↗
PubMed1977

Avian tumour virus interactions with chicken fibroblast membranes: partial characterization of initial attachment site activity.

Exposure of chicken embryo fibroblasts (CEF) to trypsin solubilizes cell surface components, including the initial attachment site for avian tumour viruses (ATV). The soluble attachment site activity appears to interact directly with the ATV in vitro thereby interfering with the binding of at least two ATV subgroups to both intact CEF and CEF plasma membranes. A result of this interaction in vitro is reduced ATV infectivity, demonstrated by reduced transforming capacity of RSV (RAV-I).

Adsorption↗
PubMed1976

Avian tumor virus interactions with chicken fibroblast plasma membranes.

A method is described which will rapidly measure the binding of avian tumor viruses (ATV) to plasma membrane receptors. With this procedure it may be shown that Rous sarcoma virus pseudotypes bind to protease-labile, heat-stable structures on the surface of chicken embryo fibroblast (CEF) plasma membranes. The binding sites for ATV subgroups A and B appear distinct, and membranes from genetically resistant CEF bind as well those of sensitive CEF.

Animals↗
PubMed1976

Planning the phasedown of mental hospitals.

With impending fiscal shortages limiting the growth of new community mental health services and the ability of mental hospitals to perform contemporary tasks remaining dubious, increased attention is being directed throughout the country to the role of state hospitals. Citizens and professionals in Massachusetts concluded that the needs of individuals now treated in mental hospitals are better met via community-based services as they become available than by services now provided in state hospitals. Consequently, public mental hospitals should be phased down over a 5-year period of time and their funds redeployed to community services. Among the factors affecting the success of this program shift are continuity of care for discharged patients, community acceptance of the mentally ill, and redeployment of personnel to community facilities.

Adult↗
PubMedDate not supplied

Advance directives for healthcare decisions--a Christian perspective.

For various reasons, many people wish to execute an advance directive for healthcare. Like other important life decisions, choices about healthcare should be consistent with the person's religious faith and values. To help people prepare an advance directive that is both accurate and reflective of Christian teaching and values, we have written the following document. Copies of An Advance Directive for Future Health Care Decisions: A Christian Perspective may be obtained in booklet form from Center for Health Care Ethics, 1402 S. Grand Blvd., St. Louis, MO 63104.

Advance Directives↗
PubMedDate not supplied

Wilson bunionectomy with internal fixation: a ten-year experience.

One hundred fifteen feet that underwent a Wilson (lateral, transpositional, shortening) osteotomy for the correction of hallux valgus between 1979 and 1989 were retrospectively reviewed. All osteotomies were stabilized either with a single cortical or cancellous screw, or with crossed Kirschner wires. The Wilson procedure is not technically difficult and can allow for tri-plane correction. Of the 115 feet on which this surgical procedure was performed, 92 (80%) were graded in long-term postoperative recovery as excellent or good. Only one complication of hallux varus occurred, which required additional surgery. Survey of the results of the 10-year experience in utilization of this operative procedure has shown a high patient satisfaction with minimum of postoperative complications and a low failure rate.

Follow-Up Studies↗