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Biomedical subjects

M McDowell

Publications and source records attributed to M McDowell.

25 records · Page 2Linked to original sources
PubMed1986

Suicide in young doctors.

Fifty-five cases of suicide by doctors under the age of 40 were studied because of concern about deaths among anaesthetists in training. The excess mortality of doctors from suicide was confirmed, suggesting that risk factors associated with being a member of the medical profession continue to operate, although mortality for young male doctors from accidental poisoning is falling. Analysis of the branches of medicine in which the doctors were working showed no definite specialty predominance. There was a somewhat greater risk for women doctors born overseas.

Adult↗
PubMed1983

An inhibitor of cerebral uptake of noradrenaline in jaundiced blood plasma.

The permeability of the blood-brain barrier to noradrenaline was estimated in rats with bile duct ligation by intracarotid injection of [14C]-L-noradrenaline, 3H2O, and [113mIn]ethylene diamine tetraacetate (EDTA) under pentobarbitone anaesthesia. Brain uptake of [14C]noradrenaline was expressed as a percentage of that of 3H2O (brain uptake index, BUI) and corrected for the "blood background" by the 113mIn. The BUI of noradrenaline (1.20 +/- 0.19) was not increased in jaundice (0.78 +/- 0.18). The capacity of oxygenated homogenates of rat brain to remove noradrenaline was measured. The presence of jaundiced plasma always caused a substantial suppression of noradrenaline removal. No effect of jaundice on specific radioactive assays for catechol-O-methyl transferase (COMT) or monoamine oxidase (MAO) could be demonstrated.

Animals↗
PubMedDate not supplied

Improving ion mass ratio performance at low concentrations in methamphetamine GC-MS assay through internal standard selection.

In federally regulated drug testing, laboratories must identify and quantitate drugs and their breakdown products by gas chromatography-mass spectrometry (GC-MS) to a concentration that is at least 60% below the cutoff concentration for reconfirmation purposes. Use of methamphetamine-d5 as an internal standard in routine testing with derivatization by HFBA was found to contribute m/z 91 and 118 ions to the same ions from the nondeuterated methamphetamine in the specimen. This resulted in poor chromatography and occasionally caused the 91/254 and 118/254 ion mass ratios to exceed the +20% acceptance limit established in the calibration process at low concentrations. The analogues methamphetamine-d8 and -d11 were evaluated for contributions to the nondeuterated methamphetamine ion fragments. Methamphetamine-d8 produced m/z 91 and 118 ions, but in less abundance than methamphetamine-d5. Methamphetamine-d11 was found to produce little or no detectable m/z 91 or 118. Replacing methamphetamine-d5 with methamphetamine-d11 eliminates this problem and allows the assay to consistently produce ion mass ratios and acceptable chromatography sufficient for identifying and quantitating methamphetamine at 60% below the 500-ng/mL cutoff concentration.

Gas Chromatography-Mass Spectrometry↗
PubMedDate not supplied

Bridging the gap between health and education: words are not enough.

OBJECTIVES: When using specific terminology for childhood developmental disorders, paediatricians make assumptions about what teachers know and believe. If these assumptions are incorrect, collaborative management may be compromised. We surveyed primary school teachers in North Brisbane regarding their beliefs about developmental disorders and their views on collaboration between medical and educational professionals. METHODS: A survey questionnaire was written specifically, and then piloted with professional colleagues and 40 teachers. Questions examined teachers' opinions about, and personal experience with various developmental disorders. Free comments addressed barriers to collaboration with doctors, and how this might be improved. Responses were analysed using descriptive statistics. RESULTS: Responses were received from all of the 41 schools surveyed. Overall, completed questionnaires were obtained from 297 of 397 (75%) primary classroom teachers surveyed. Several apparent misconceptions were held, either by the majority (e.g. 70% felt dietary modification is commonly successful treatment for ADHD), or by a significant minority of teachers (e.g. 23% believed autistic spectrum disorder is not a permanent neurological condition). Responses to many questions concurred with the authors' assumptions. Teachers reported high levels of concern about lack of training and resource support for managing special-needs children. Over three-quarters of teachers did not access doctors for information, relying instead on special education professionals (96%) or parents (94%). Few group differences were noted by age, sex, years teaching experience, or system (Catholic, State). Free comments identified significant barriers to the collaboration process, and suggested strategies to address these. CONCLUSIONS: Doctors cannot assume teachers' beliefs about developmental disorders are similar to their own. Furthermore, doctors should recognize constraints that teachers work under, and can take the initiative to improve collaboration with topic-based as well as child-specific information.

Child↗