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Biomedical subjects

M McCollum

Publications and source records attributed to M McCollum.

7 recordsLinked to original sources

AIDS exceptionalism.

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Acquired Immunodeficiency Syndrome↗

A trip through time.

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American Hospital Association↗

In vitro type II binding of chromosomal DNA to membrane in Bacillus subtilis.

DNA-membrane association critical for initiation of DNA replication in Bacillus subtilis can be classified into two types. Type I is salt resistant and dependent on the initiation gene, dnaB, and type II is salt sensitive and independent of the dnaB gene. We found and sequenced two adjacent areas of type II binding within 1% of oriC on the B. subtilis chromosome.

Amino Acid Sequence↗

The influence of splinting on healing tissues.

In addition to immobilizing injured soft tissue to allow healing, splints are used to positively influence collagen remodeling through the application of low-load forces to healing or contracted soft tissue, permitting soft tissue growth and concomitant increased function. When correction of limited passive range of motion due to soft tissue contracture is needed, splinting is an absolute requisite. No other currently available modality is able to hold a constant low-load tension for a prolonged time sufficient to cause tissue growth.

Contracture↗

Evolution and development of teeth.

Teeth as a feeding mechanism in an oral cavity (mouth) are functionally and locationally linked with jaws. In fossils, teeth found in the oral cavity are usually linked with jaws, although mineralised structures with the same histology as teeth are known in fossils before jaws appeared. Denticles in the skin occur in both fossil and extant fish. Pharyngeal denticles also occur in both extant and fossil gnathostomes but in only a few fossil agnathans (thelodonts). Complex structures with dentine and enamel have been described in the earliest jawless vertebrates, conodonts. Such fossils have been used to suggest that teeth and jaws have evolved and developed independently. Our understanding of the developmental biology of mammalian tooth development has increased greatly in the last few years to a point where we now understand some of the basic genetic interactions controlling tooth initiation, morphogenesis and patterning. The aim of this review is to see what this developmental information can reveal about evolution of the dentition.

Animals↗