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Biomedical subjects

M McCarthy

Publications and source records attributed to M McCarthy.

At least 397 records · Page 22Linked to original sources
PubMed1979

My staff come first.

Explore the source record for details and available documents.

Collective Bargaining↗
PubMed1979

The misplaced-objects task: a brief test for memory dysfunction in the aged.

A brief, simple test for memory dysfunction in the aged is presented. Materials for the test consist of: 1) a board on which the cross-section of a seven-room house is imprinted, and 2) representations of 10 objects frequently misplaced in the home (e.g., keys). The task of the subject is to place the objects in rooms on the board and, after an interval of 5--30 minutes, to recall the location of each object. The measure is appropriate for a broad range of aged subjects, since performance requirements are minimal and readily apparent. The task has obvious face validity, which is essential for maintaining appropriate motivation in many aged subjects. Discriminate validity was demonstrated in a study in which significantly fewer objects were recalled by 60 aged persons with memory impairment (-x = 6.0) than by 44 unimpaired aged persons (-x = 8.9) or 63 young normal persons (-x = 9.9). Satisfactory test-retest reliability was demonstrated by a correlation of .84 between performances on two consecutive days in a subgroup of 20 impaired patients. Subjects appeared to enjoy the game-like structure of the test and clearly were not threatened by the test procedures. Suggestions are offered for further development of the measure.

Aged↗
PubMed1978

A phonocardiographic study of equine heart sounds.

The occurrence and timing of heart sounds were examined from phonocardiograms taken from the mitral, aortic and tricupsid recording areas in each of 18 horses. 10 sound events could be identified with each cardiac cycle. Atrial contraction produced up to 3 sound events. The first heart sound consisted of 4 components whereas the second sound was single. Two sound events were associated with the 3rd heart sound in early diastole. The occurrence of third and fourth heart sound components varied between horses and between recording areas. The mitral recording area was considered most satisfactory for routine phonocardiographic studies in horses.

Animals↗
PubMed1978

Effects of a stimulant drug on extraversion level in hyperactive children.

7 hyperactive children in a pilot study, and 15 hyperactive and 15 non-hyperactive control children in a later study, were assessed for salivation to lemon juice stimulation, reactive inhibition on an audio-vigilance task, and visual-motor maze errors. Hyperactive children were tested under stimulant drug and nondrug conditions and nonhyperactive children twice under nondrug conditions. Pilot study hyperactive children displayed significantly fewer maze errors and somewhat greater salivation and lesser reactive inhibition levels under the drug than the nondrug conditions. Follow-up study control children did not differ significantly between test occasions on any measure, while the hyperactive children displayed significantly fewer maze errors, more salivation, and less reactive inhibition under the stimulant drug, indicating significant decreases in extraversion after the stimulant drug.

Adolescent↗
PubMed1978

Relationship between apex cardiogram and left ventricular pressure events in Greyhound dogs.

Temporal relationships between the left apex cardiogram (ACG) and left ventricular and aortic pressure events were studied in 10 anesthetized Greyhound dogs. A close relationship existed between onset of the upstrokes of the ACG and left ventricular pressure. The nadir of the protosystolic upstroke of the ACG invariably occurred after the peak rate of change of left ventricular pressure increase (d/dt)LVP and the onset of aortic pressure increase, but occurred virtually simultaneously with the peak rate of change of aortic pressure increase (d/dt)A. The relationship between the protodiastolic nadir of the downstroke of left ventricular pressure and that of the ACG was close but variable. The ACG could be of value as a noninvasive examination technique in canine cardiovascular studies.

Animals↗
PubMed1977

A method for indirect measurement of arterial blood pressure in the horse.

A method using the Doppler ultrasound principle for indirect determination of arterial blood pressure in the horse is described. The method is simple and suitable for field situations. Validation studies show that systolic and diastolic blood pressure measurements bear a close relationship to true values obtained by direct measurement.

Animals↗
PubMed1977

The value of arterial blood pressure measurement in assessing the prognosis in equine colic.

Indirect arterial blood pressure was determined on 33 horses prior to surgical intervention for the diagnosis and/or correction of acute abdominal disorders and a relationship between low systolic blood pressure and non-survival was established. It is suggested that blood pressure determination should be used to augment other methods of clinical and laboratory examination in cases of equine colic.

Animals↗
PubMed1977

Glycosidase susceptibility: a probe for the distribution of glycoprotein oligosaccharides in Sindbis virus.

Intact Sindbis virus and Triton-solubilized viral glycoprotein were treated with alpha-mannosidase and with a preparation of mixed glycosidases from Diplococcus pneumoniae to probe the accesibility of carbohydrate units on the viral surface. The products of glycosidase attack on Triton-solubilized virus showed that mose carbohydrate units of the glycoproteins are good substrates for these enzymes. The relative resistance of most of the viral oligosaccharides in intact virus particles showed that much of the carbohydrate is not accessible to glycosidases, probably because it is not exposed at the viral surface. The only completely accessible carbohydrate units on Sindbis glycoproteins were the type A oligosaccharides of E2. This differential accessibility of Sindbis oligosaccharides is discussed in relation to the organization of the viral surface.

Fucose↗
PubMed1976

Interactions between aminoglycoside antibiotics and carbenicillin or ticarillin.

Carbenicillin or ticarcillin were incubated individually with each of the following antibiotics: gentamicin, tobramycin, sisomicin, amikacin. The residual activity of each aminoglycoside in this mixture was assayed enzymatically. Amikacin was inactivated the least of the aminoglycosides. Both penicillins inactivated each aminoglycoside to a similar extent by a degree which varied according to the medium of incubaiton, the least inactivation being seen in pooled human serum and the most in phosphate buffer at pH 7.4.

Amikacin↗
PubMed1975

Medical care of childhood leukaemia.

The medical care given to a population-based sample of children with leukaemia was reviewed between two to three years after diagnosis. Just over half the children had been treated at local hospitals, and the others referred to centres specialising in treatment of leukaemia. Local hospitals could be divided according to the therapeutic regimen used; the survival of children given optimal regimens at local hospitals was equivalent to that of two of the three special centres. Assessment of social, psychological, satisfaction or cost outcomes showed no difference between the groups. It is concluded that a regional policy for childhood leukaemia should be concerned to improve treatment regimens at local hospitals rather than attempt to concentrate care at a few centres.

Adolescent↗
PubMed1975

Changes in elderly welfare hotel residents during a one-year period.

After a one-year interval, a structured interview designed to assess the quality of life was again conducted with most of the tenants in a single-room occupancy hotel in New York City. Comparisons was made between the two sets of findings. During the year, a program had been in effect to provide social, psychiatric, recreational, medical and other services to all the tenants at the hotel. Of the original 181 interviewees, 100 completed the second interview. Statistically significant changes occurred in 9 of the 35 variables assessed for the one-year period. There was significant improvement in the self-care index, but some negative mood changes were also found. The subgroup of identified alcholics showed the most positive improvements of any of the subgroups.

Female↗