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Biomedical subjects

M McCamish

Publications and source records attributed to M McCamish.

9 recordsLinked to original sources

AIDS education.

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Acquired Immunodeficiency Syndrome

Influence of human immunodeficiency virus antibody testing on sexual behaviour in a "high-risk" population from a "low-risk" city.

A survey was undertaken of homosexual and bisexual men in Brisbane to establish whether knowledge of their human immunodeficiency virus (HIV)-antibody status had influenced any sexual behaviour that was likely to spread HIV type 1 (HIV-1). Of the 318 respondents, 123 respondents knew their HIV serological status, and 13 of these were HIV seropositive. Of the 195 respondents who previously had not been tested, 10 individuals proved to be HIV seropositive. Eighty-two per cent of subjects stated that they had reduced their sexual activity because of their awareness of the acquired immunodeficiency syndrome (AIDS); this reduction was equally common among those who had or had not previously had their HIV serological status checked. Anal intercourse was practised most frequently by those subjects who were HIV seropositive and were not aware of it; nevertheless, unprotected anal intercourse was common among subjects who knew their HIV serological status, including those who knew that they were HIV seropositive. Eighty-nine of 208 subjects who were practising anal intercourse had never used a condom. Usage of a condom was marginally more common among those subjects who previously had been tested for the presence of HIV antibodies (P = 0.06), and this was particularly so for those subjects who knew that they were HIV seropositive (P less than 0.01). Condom usage was no more common among those subjects who knew that they were HIV seronegative, when compared with those subjects who did not know their status. These data show that knowledge of a negative HIV-antibody test-result has no substantial association with safer sexual behaviour and suggest that whereas targeted information programmes have had some impact on behaviour in high-risk groups in Brisbane, by the end of July 1986, these programmes had not yet resulted in safer sexual practices by the majority of homosexual and bisexual men.

AIDS Serodiagnosis

Collisional activation decomposition of actinomycins using tandem mass spectrometry.

The collisional activation (xenon) decomposition of actinomycin V, dactinomycin, 7-nitrodactinomycin, 7-aminodactinomycin, and a mixture of dactinomycin, actinomycin C1 and actinomycin C2 was studied using a triple-quadrupole mass spectrometer with fast atom bombardment (xenon) ionization. Fragmentation pathways of the structurally significant ions were rationalized by assuming an initial McLafferty rearrangement at the ester linkage between the methylvaline and the threonine of both rings to form linear pentapeptides, followed by fragmentation in either pentapeptide yielding typical sequence ions and sequence cleavages from both rings.

Dactinomycin

The nonpolar egg wax lipids of the cattle tick, Boophilus microplus (canestrini).

About 40% of the lipids of the egg wax of Boophilus microplus are nonpolar and comprise hydrocarbons (10%) and wax esters (90%). The hydrocarbon fraction is 87% unbranched alkanes, the major components being n-nonadecane (10.8%), n-eicosane (12.1%), and n-heneicosane (9.8%). This fraction also contains 2,4,6-cholestatriene (4.6%). The majority of the acids are branched (77%) the major components being 12-methyl-tetradecanoic (16.3%) and branched hexadecanoic acids (28%). The major alcohols are n26:0 (20.4%), n28:0 (47.3%) and n36:0 (18.2%). A steroid possibly 2,4,6-cholestatrien-25-ol (5.6%), is also present.

Animals

Knowledge about AIDS.

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Acquired Immunodeficiency Syndrome