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Biomedical subjects

M Mayer

Publications and source records attributed to M Mayer.

At least 433 records · Page 24Linked to original sources
PubMedDate not supplied

[Quantifying mineralization processes in post-traumatic algodystrophy using computerized tomography densitometry].

Computed tomography examinations have been made in 12 patients with posttraumatic algodystrophy. Significant differences of sides were found to be a measure of demineralisation by CT densitometry. 7 patients could be repeatedly examined during up to 60 weeks after the trauma. CT-integrated densitometry enables to quantify the process of de- and remineralisation and to objectify the disease according to the spongiosa bone. It seems to be possible to value the process of mineralisation by this method.

Absorptiometry, Photon↗
PubMedDate not supplied

Discriminant analysis for the diagnosis of childhood celiac disease.

A new statistical approach to the analysis of laboratory data has been introduced to optimize the use of absorption tests and gliadin antibody measurement for the diagnosis of childhood celiac disease. Serum antigliadin antibodies, as well as blood xylose, iron, and tryglycerides after oral load, were evaluated in 40 celiac children and 43 age-matched patients affected by other gastrointestinal diseases. Each test evaluated individually gave a considerable rate of false-positive and false-negative results. Discriminant coefficients produced for each test were used to compute a score that allowed correct classification of 99% of patients; 2.3% of false-positive and no false-negative results were recorded. This approach improves significantly the overall sensitivity and specificity for celiac disease of these laboratory tests and we propose its use for screening patients to be submitted to jejunal biopsy.

Adolescent↗
PubMedDate not supplied

Case control study on nutritional risk factors in celiac disease.

This study explored whether risk or protective nutritional factors have a role in childhood celiac disease. The effect of bottle feeding and early introduction of gluten to the diet was evaluated in a case control study. For each case, about 10 controls were recruited: sample size was determined as required for the evaluation of the study hypothesis. Patients were significantly less breast fed than were controls. Bottle-fed children had an earlier introduction of gluten to the diet than did controls, but when early gluten introduction was analyzed across strata of breast-fed or bottle-fed children, no risk was attributed to it. Bottle feeding appeared to be a significant risk factor in children who received gluten early as well as in those who received gluten later. Breast-feeding rates for patients and controls were equal at birth, but lower for patients by the age of 1 month: from then onward, there was a constant difference between patients and controls regarding the percentage still at breast. Interruption of breast feeding was a risk factor in celiac disease, but early gluten introduction did not appear to be a similar risk factor in the present study.

Bottle Feeding↗
PubMedDate not supplied

Atopy and coeliac disease: bias or true relation?

Several reports have suggested a relationship between atopy and coeliac disease and atopy has also been linked to the pathogenesis of the mucosal damage. Conclusive epidemiological evidence of the relationship has not been satisfactorily established. The case-control study reported here was undertaken to test the hypothesis that coeliac disease is linked to atopy. Eighty-two coeliac disease cases and a group of 180 age matched controls and all their first degree relatives were investigated for atopy. Siblings of cases reported an increased prevalence of food intolerance, compared to siblings of controls. No increase in asthma, eczema, rhinitis, conjunctivitis, cow's milk protein allergy (CMPA) were detected in relatives of cases, compared to those of controls. When each index case and each control were investigated no increased prevalence of atopic conditions was found. Skin prick testing to major allergens was positive in a similar proportion of cases and controls. Serum total IgE of a random sample of cases and controls showed no difference in mean values. This study supports the null hypothesis: there is no difference in the prevalence of atopy in cases affected by coeliac disease and their relatives, compared to controls and their relatives. The sources of possible bias in previous reports are discussed.

Case-Control Studies↗
PubMedDate not supplied

[Hospitalization for systemic connective tissue diseases in Croatia in 1997: examples of the use of hospital morbidity registery data bases].

By using the explanatory analysis methods, we examined a possible model for the utilization of the Croatian Hospital Morbidity Register data for decision making in the managerial process for national health system development. To build a draft informational model, data were selected on 843 cases hospitalized in 1997 for diseases M30-M36 (ICD-10) in 45 health institutions. This was used as an index of the diagnostically/therapeutically most demanding group of rheumatic autoimmune diseases. Treatment standards were established for our health system for the patients having an M30-M36 disease by classifying Croatia's health institutions into four clusters by intensity of hospitalization, and by analyzing demographic characteristics and the length of stay by disease entity. These standards could represent a good informational base for forming consensus group panels to deal with inpatient treatment problems of patients with systemic connective tissue diseases.

Adolescent↗
PubMedDate not supplied

[Idiopathic eosinophilia with ascites (case report)].

Hypereosinophilia can present a diagnostic problem if initial diagnostic procedures (medical history, physical examination and basic laboratory exams) fail to reveal the cause. Persistent finding of hypereosinophilia in such patients demands diagnostic intervention in order to rule out neoplastic and lymphoproliferative diseases, chronic inflammatory diseases of respiratory and gastrointestinal system and skin, and other inflammatory and postinflammatory conditions. If these disorders are ruled out, consideration should also be given to the diagnosis of primary hypereosinophilia, including idiopathic hypereosinophilic syndrome. The paper presents a patient with significant elevation of absolute and relative numbers of eosinophils in whom the only physical pathologic finding was eosinophilic ascites. Extensive diagnostic investigation did not prove secondary character of abnormalities, and since all pathologic findings receded during 7-month observation without treatment, the conclusion was that the disorder was benign.

Adult↗
PubMedDate not supplied

Reference values and modelling of lung function development as a transcendent function of age, body height and mass.

We present new lung function reference values based on an investigation of 1024 healthy subjects aged 6-81 years. The dependent variables, i.e. VC, FEV1, RV, FRC, TLC, PEF, MEF50 and MEF25 are expressed as transcendent functions of age, body height and mass. A single equation covers the age range from 6 to 81 years and reflects certain phenomena such as growth, maturation, ageing, sex differences and the undermass-overmass effect. This allows a more accurate determination of individualized reference values and normal limits.

Adolescent↗
PubMedDate not supplied

[Vertebral eosinophilic granuloma and spinal cord compression].

We describe a case of spinal eosinophilic granuloma inducing a medullary compression syndrome. However, this condition appears to be very infrequent, since only 16 cases were reported in literature. The difficulties of the diagnosis of this disease and its therapeutic management are discussed.

Eosinophilic Granuloma↗