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Biomedical subjects

M Mayer

Publications and source records attributed to M Mayer.

At least 361 records · Page 20Linked to original sources
PubMed1977

Proliferation characteristics of erythroblasts in chronic renal failure.

Proliferation of bone marrow erythroblasts in patients with chronic renal disease was studied by combined application of cytophotometric measurement of the DNA content and 3H-TdR labeling in vitro. A striking decrease of 3H-TdR labeling was found in most of the cases. The proportion of diploid (G0 + G1) as well as of tetraploid unlabeled cells (G2) was increased. The data suggest a disturbed induction of DNA synthesis of resting cells as well as an arrest of cells in G2 being responsable for ineffective cell production in this disease.

Adult↗
PubMed1977

In vivo labeling of platelets with 75Se -- selenomethionine in patients with hepatic cirrhosis and thrombocytopenia.

Labeling of platelets in vivo by 75Se -- Selenomethionine (75Se-M) was performed in nine cases of hepatic cirrhosis and thrombocytopenia for evaluation of the kinetics of platelet maturation. Folic acid and vitamin B12 deficiency was excluded by pretreatment of the patients with these agents. The platelet maturation time -- time between the injection of the isotope and maximum radioactivity of separated blood platelets -- was shortened to 7.7 +/- 1.1 days (mean +/- SD) compared to the normal 9.1 +/- 1.4 days. For explanation a disturbance of megakaryocyte maturation and/or platelet release from the bone marrow is suggested.

Adult↗
PubMed1977

A new topographic approach to the spread of breast cancer: the grid method.

In a series of 181 patients with breast cancer treated by mastectomy with axillary lymph node dissection, the authors developed and used an improved topographic technique, which they call the "Grid Method", which maps out the extent of a given cance of the breast. Three types of tumor spread are defined: Type 1, limited (L)(31%); Type 2, multifocal (M)(13.2%); and Type 3, extensive (E)(55.8%). This topographic information allows a more accurate assessment of prognosis when used in conjunction with the morphologic findings. Moreover, the topographic "Grid" study is simple to perform and easy to assess. Of prime importance is the relationship between the topographic and mammographic findings.

Axilla↗
PubMed1977

A topographic approach to breast cancer: the relation of topographic and mammographic findings.

One hundred and twenty-eight patients with breast cancer who, on the basis of mammographic study, were treated by mastectomy were analyzed. The purpose of this endeavor was to correlate the roentgenologic features with the pathologic findings. The correlation between them was very good: the type of tumor opacity, the microcalcifications, and the various other radiologic patterns were compatible with both localized and extensive breast cancer. Mammography appears to be valuable in the selection of patients suitable for conservative treatment.

Breast Neoplasms↗
PubMed1977

In vivo study of platelet kinetics by 75Se-methionine in different haematological disorders.

Labeling of platelets in vivo by 75Se-methionine was performed in premalignant and malignant haematological disorders for evaluation of the kinetics of platelet maturation. The "normal" platelet maturation time (time between the injection of the isotope and maximum radioactivity of separated blood platelets) in eight non-haematological patients showing normal platelet counts was 9.1 days. A shortening of platelet maturation time of 5-7 days was observed in three of four cases with panmyelopathy (high bone marrow cellularity), in three of four cases with malignant lymphatic disorders (multiple myeloma, chronic lymphocytic leukaemia, lymphosarcoma), and in two of four cases with myeloproliferative syndromes. No correlation to the peripheral platelet counts was observed. For explanation of the premature platelet release from the bone marrow a disturbance of the megakaryocyte maturation is suggested.

Adult↗
PubMed1977

[Hormonal factors in the prediction of hormonedependency of breast cancer].

Biological diagnostic of hormonedependency of breast tumors is important for the choice of treatment. Modifications of the metabolism of steroids, oestrogens, androgens, and glucocorticoids allowed a first approach. More recently, investigations have been made on breast tissue receptors for hormones that are involved in the growth of the normal gland. It is actually suggested that one could predict the hormonedependency of a tumor when it contains both receptors for oestradiol and progesterone.

Breast Neoplasms↗
PubMed1977

[Comparative study on x-ray and scintigraphie pictures and blood gases in sarcoidosis (author's transl)].

Scintigraphic examination of the lungs in sarcoidosis has been used as a supplement method of the functional examination. Perfusion scintigraphy enables to locate places with lowered regional perfusion in the form of spotted fall outs. In some cases of hilar lymphonodular forms of sarcoidosis we can already find some diffuse spotted fall outs of perfusion even if parenchymatous changes are still not visible. Up to now we have not seen any lobar or alar fall outs of radioactivity, as they can be found in central types of bronchogenic carcinoma. In sarcoidosis with micro- or macronodular X-ray shadows the scintigraphic defect in its extent sometimes does not correspond to these changes. On the basis of our material the mutual relation between scintigraphic pictures on one hand and blood gases on the other hand could not been neither confirmed nor eliminated.

Blood Gas Analysis↗
PubMed1976

[Glycoside induced intestinal ischemia. Therapeutic possibilities (author's transl)].

Intestinal infarction in the absence of organic vascular occlusion received increasing attention in recent years. There is strong evidence from experimental work and clinical observations that cardiac glycosides may play an important role in the pathophysiology of this disorder. Our experiments using the so called mechanical ventricular massage confirm this theory. We could demonstrate that the decrease in mesenteric arterial perfusion following the i.v. administration of ouabain is caused by extracardiac effects of the glycoside on vascular smooth muscle. The Ca++ -antagonistic compound (Verapamil) blocks and reverses the Ca++-synergistic action of the glycoside independent of the time of injection.

Animals↗
PubMed1976

The valve of chemotherapy in the treatment of testicular dysembryoplastic tumors.

Chemotherapy appears to be of help in treating dysembryoplastic testicular tumors. It seems better to treat first by surgery (lymphadenectomy) if possible, then (a) if no nodes are involved or only one has been discovered by microscope examination, with chemotherapy for one year; or (b) if two or more nodes are involved, with irradiation of the nodes and chemotherapy. Even if lymphadenectomy is not possible, one course of chemotherapy followed by cobalt and more chemotherapy can bring results in some cases.

Cyclophosphamide↗